Recombining binding protein suppressor of hairless Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide	IC50	48.3 [1]
	(2S,3R)-N'-[(3S)-7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-prop-2-enylbutanediamide	IC50	74.5 [1]
	(2S,3R)-3-(2-Methylpropyl)-N'-[(3S)-2-oxo-5-phenyl-1-propyl-3H-1,4-benzodiazepin-3-yl]-2-prop-2-enylbutanediamide	IC50	12.5 [1]
	(2S,3R)-2-Butyl-N'-[(3S)-5-(4-chlorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide	IC50	13.5 [1]
	(2S,3R)-N'-[(3S)-9-Aminooxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3-fluoropropyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	15.4 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.4 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1.4 [1]
	(2S,3R)-2-(4,4-Difluorocyclohexyl)-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	6.0 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4-difluorocyclohexyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	8.9 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[4-(trifluoromethyl)cyclohexyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	21.2 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4-difluorocyclohexyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	7.3 [1]
	(2S,3R)-2-(3,3-Difluorocyclobutyl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	18.9 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.1 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.0 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.4 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.3 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.4 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.8 [1]
	(2S,3R)-2-(3-Fluoropropyl)-N'-[(3S)-8-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	11.0 [1]
	(2S,3R)-2-(2,2-Difluoropropyl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	10.8 [1]
	(2S,3R)-N'-[(3S)-9-Fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2S)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.4 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3-fluoropropyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	16.5 [1]
	(2S,3R)-2-(3,3-Difluorobutyl)-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	13.8 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2R)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	9.3 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2S)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.2 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3,3-difluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.4 [1]
	(2S,3R)-2-[(1-Fluorocyclobutyl)methyl]-N'-[(3S)-9-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	20.1 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-fluoro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.2 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 29 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Recombining binding protein suppressor of hairless Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/recombining-binding-protein-suppressor-of-hairless-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Recombining binding protein suppressor of hairless Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/recombining-binding-protein-suppressor-of-hairless-inhibitors-ic50-ki.
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