 | (2E,4E,6Z)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 0.0 [1], 8.0 [2] |
| (2E,4E,6Z)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 1.5 [1], 2.7 [2], 3.0 [3], 18.0 [4] |
 | Bexarotene | Ki | 14.0 [1], 16.0 [2], 21.0 [3], 36.0 [4] |
 | Alitretinoin | IC50 | 29.0 [1], 32.0 [2] |
| Alitretinoin | Ki | 8.0 [1], 8.4 [2], 12.0 [3] |
 | Tretinoin | IC50 | 1000.0 [1] |
| Tretinoin | Ki | 0.4 [1], 330.0 [2], 350.0 [3] |
 | 6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid | IC50 | 8.0 [1] |
| 6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid | Ki | 3.0 [1], 12.9 [2], 18.0 [3] |
 | CID 11755040 | IC50 | 290.0 [1], 900.0 [2], 1200.0 [3] |
 | (2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | IC50 | 6.8 [1] |
| (2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 7.8 [1] |
 | 7-(2-Butoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid | IC50 | 4.0 [1] |
| 7-(2-Butoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid | Ki | 4.0 [1] |
 | 7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid | IC50 | 8.0 [1] |
| 7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid | Ki | 11.0 [1], 11.4 [2] |
 | 7-(2-Ethoxy-3,5-diisopropyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid | Ki | 2.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(2-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 3.1 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(2-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.3 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(3-fluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | IC50 | 8.0 [1] |
| (E)-3-[4-[3,5-Ditert-butyl-2-(3-fluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 3.0 [1] |
 | (E)-3-[4-(3,5-Diisopropyl-2-propoxy-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid | IC50 | 16.0 [1] |
| (E)-3-[4-(3,5-Diisopropyl-2-propoxy-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid | Ki | 14.0 [1] |
 | (E)-3-[7-(3,5-Diisopropyl-2-propoxy-phenyl)-benzofuran-2-yl]-but-2-enoic acid | IC50 | 128.0 [1] |
| (E)-3-[7-(3,5-Diisopropyl-2-propoxy-phenyl)-benzofuran-2-yl]-but-2-enoic acid | Ki | 44.0 [1] |
 | (Z)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | IC50 | 22.0 [1] |
| (Z)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | Ki | 101.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | IC50 | 24.0 [1] |
| (E)-3-[4-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 12.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(3,3-difluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | IC50 | 16.0 [1] |
| (E)-3-[4-[3,5-Ditert-butyl-2-(3,3-difluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 7.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | IC50 | 14.0 [1] |
| (E)-3-[4-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 3.0 [1] |
 | (E)-3-{7-[2-(3-Fluoro-propoxy)-3,5-diisopropyl-phenyl]-benzofuran-2-yl}-but-2-enoic acid | IC50 | 194.0 [1] |
| (E)-3-{7-[2-(3-Fluoro-propoxy)-3,5-diisopropyl-phenyl]-benzofuran-2-yl}-but-2-enoic acid | Ki | 47.0 [1] |
 | (E)-3-[7-[3,5-Di(propan-2-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | IC50 | 347.0 [1] |
| (E)-3-[7-[3,5-Di(propan-2-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | Ki | 198.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 1.0 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.0 [1] |
 | (E)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | IC50 | 300.0 [1] |
| (E)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | Ki | 161.0 [1] |
 | (2E,4E,6Z)-7-[2-Ethoxy-3,5-bis(2-methylbutan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 17.0 [1] |
| (2E,4E,6Z)-7-[2-Ethoxy-3,5-bis(2-methylbutan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.0 [1] |
 | (2E,4E,6Z)-7-[2-(2-Fluoroethoxy)-3,5-di(propan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 4.0 [1] |
| (2E,4E,6Z)-7-[2-(2-Fluoroethoxy)-3,5-di(propan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 1.0 [1] |
 | (2E,4E,6Z)-7-[3,5-Bis(2-methylbutan-2-yl)-2-propoxyphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 13.0 [1] |
| (2E,4E,6Z)-7-[3,5-Bis(2-methylbutan-2-yl)-2-propoxyphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 23.0 [1] |
 | 7-(3,5-Diisopropyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid | IC50 | 4.0 [1] |
| 7-(3,5-Diisopropyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid | Ki | 3.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(2-methylbutan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 16.0 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(2-methylbutan-2-yl)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 29.0 [1] |
 | 4-(2-Cyano-5-ethyl-7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)-2-fluorobenzoic acid | IC50 | 500.0 [1], 770.0 [2] |
 | 4-[5-Ethyl-7,7,10,10-tetramethyl-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 95.0 [1], 160.0 [2] |
 | 4-[7,7,10,10-Tetramethyl-5-propyl-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 76.0 [1], 190.0 [2] |
 | (E)-3-[4-(3,5-Ditert-butyl-2-heptoxyphenyl)-1-benzothiophen-2-yl]but-2-enoic acid | IC50 | 83.0 [1] |
| (E)-3-[4-(3,5-Ditert-butyl-2-heptoxyphenyl)-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 5.0 [1] |
 | (Z)-3-[7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | IC50 | 11.0 [1] |
| (Z)-3-[7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | Ki | 16.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(furan-2-yl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 3.6 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(furan-2-yl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 3.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-propan-2-yl-5-thiophen-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 1.9 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-propan-2-yl-5-thiophen-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 0.8 [1] |
 | (2E,4E,6E)-7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | IC50 | 4.7 [1] |
| (2E,4E,6E)-7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 4.4 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 3.9 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 1.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3,5-difluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 4.6 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3,5-difluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.6 [1] |
 | (2E,4E,6Z)-3-Methyl-7-[3-(1,1,2,2,2-pentafluoroethyl)-5-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | IC50 | 10.7 [1] |
| (2E,4E,6Z)-3-Methyl-7-[3-(1,1,2,2,2-pentafluoroethyl)-5-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | Ki | 85.8 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-phenyl-5-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 57.9 [1] |
| (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-phenyl-5-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 6.1 [1] |
 | (2E,4E,6Z)-3-Methyl-7-[5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | IC50 | 5.1 [1] |
| (2E,4E,6Z)-3-Methyl-7-[5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | Ki | 25.6 [1] |
 | (2E,4E,6Z)-7-[2-Ethoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | IC50 | 5.3 [1] |
| (2E,4E,6Z)-7-[2-Ethoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 6.3 [1] |
 | 4-(5,7,7,10,10-Pentamethyl-2-methylsulfanyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 2000.0 [1], 3000.0 [2] |
 | 4-[2-(4-Methoxyphenyl)sulfanyl-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 720.0 [1], 1600.0 [2] |
 | 4-[5,7,7,10,10-Pentamethyl-2-[4-(trifluoromethoxy)phenyl]sulfanyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 390.0 [1], 1000.0 [2] |
 | 4-[2-[(4-Chlorophenyl)methylsulfanyl]-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 670.0 [1], 1600.0 [2] |
 | 4-[2-[(4-Methoxyphenyl)methylsulfanyl]-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 4900.0 [1], 5500.0 [2] |
 | 4-(5,7,7,10,10-Pentamethyl-2-methylsulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 1400.0 [1], 1700.0 [2] |
 | 4-(5,7,7,10,10-Pentamethyl-2-propylsulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 450.0 [1], 920.0 [2] |
 | 4-[2-(4-Methoxyphenyl)sulfonyl-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 170.0 [1], 360.0 [2] |
 | 4-[5,7,7,10,10-Pentamethyl-2-[4-(trifluoromethoxy)phenyl]sulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 130.0 [1], 240.0 [2] |
 | 4-[2-[(4-Chlorophenyl)methylsulfonyl]-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 420.0 [1], 950.0 [2] |
 | 4-[2-[(4-Methoxyphenyl)methylsulfonyl]-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 780.0 [1], 1400.0 [2] |
 | 4-[5,7,7,10,10-Pentamethyl-2-(methylsulfamoyl)-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 1300.0 [1] |
 | 4-[2-(Dimethylsulfamoyl)-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 2000.0 [1], 2200.0 [2] |
 | 4-[2-(Butylsulfamoyl)-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 190.0 [1], 410.0 [2] |
 | 4-[5,7,7,10,10-Pentamethyl-2-[[4-(trifluoromethoxy)phenyl]sulfamoyl]-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 460.0 [1], 960.0 [2] |
 | 4-(5,7,7,10,10-Pentamethyl-2-pyrrolidin-1-ylsulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 450.0 [1], 1000.0 [2] |
 | 4-(5,7,7,10,10-Pentamethyl-2-morpholin-4-ylsulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 450.0 [1], 1000.0 [2] |
 | 4-[5,7,7,10,10-Pentamethyl-2-(4-methylpiperazin-1-yl)sulfonyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid | IC50 | 1000.0 [1], 1900.0 [2] |
 | 4-(5,7,7,10,10-Pentamethyl-2-morpholin-4-yl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 3900.0 [1], 7000.0 [2] |
 | 4-(2-Acetyl-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 890.0 [1], 1100.0 [2] |
 | 4-(2-Acetyl-5-ethyl-7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 790.0 [1], 970.0 [2] |
 | 4-(2-Acetyl-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)-2-fluorobenzoic acid | IC50 | 1100.0 [1], 1700.0 [2] |
 | 4-(2-Acetyl-5-ethyl-7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)-3-fluorobenzoic acid | IC50 | 3000.0 [1], 3300.0 [2] |
 | 4-(2-Cyano-5-ethyl-7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | IC50 | 320.0 [1], 480.0 [2] |
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