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Retinoid X receptor beta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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TretinoinIC501000.0 [1]
TretinoinKi0.5 [1], 54.0 [2], 881.0 [3]
AlitretinoinIC5012.0 [1]
AlitretinoinKi3.8 [1], 7.4 [2], 9.0 [3]
BexaroteneKi5.9 [1], 21.0 [2]
6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acidKi7.5 [1], 75.0 [2]
(2E,4E,6Z)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methylocta-2,4,6-trienoic acidKi4.0 [1], 18.0 [2]
FenretinideKi2800.0 [1]
TtnpbIC501000.0 [1]
CID 11755040IC5044.0 [1]
4-(2,18,18,21,21-Pentamethyl-2,14-diazapentacyclo[13.8.0.03,12.04,9.017,22]tricosa-1(15),3(12),4,6,8,10,13,16,22-nonaen-13-yl)benzoic acidKi1700.0 [1]
(2E,4E,6Z)-3-Methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acidKi9.0 [1]
4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzothiazepin-12-yl)benzoic acidKi400.0 [1]
4-(5,7,7,10,10-Pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acidKi640.0 [1]
7-(3,5-Ditert-butylphenyl)-3-methylocta-2,4,6-trienoic acidKi560.0 [1]
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoic acidKi191.0 [1]
3-[5-(4-Chloro-3-methyl-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acidIC5011000.0 [1]
4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl) benzoic acidIC501000.0 [1]
4-[(Z)-N-Hydroxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi120.0 [1]
(2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acidKi11.5 [1]
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acidKi199.0 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(2-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi16.0 [1]
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acidIC5050.0 [1]
(E)-3-[4-[3,5-Ditert-butyl-2-(3-fluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acidKi10.0 [1]
4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzoxazepin-12-yl)benzoic acidKi1200.0 [1]
4-[(E)-C-(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-N-prop-2-enoxycarbonimidoyl]benzoic acidKi15.0 [1]
4-[(E)-N-Butoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi283.0 [1]
(E)-3-[4-(3,5-Diisopropyl-2-propoxy-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acidKi15.0 [1]
4-[(E)-C-(3-Bromo-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-N-hydroxycarbonimidoyl]benzoic acidKi6.0 [1]
(Z)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acidKi4.0 [1]
(E)-3-[4-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acidKi55.0 [1]
(E)-3-[4-[3,5-Ditert-butyl-2-(3,3-difluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acidKi12.0 [1]
(E)-3-[4-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acidKi10.0 [1]
(E)-3-[7-[3,5-Di(propan-2-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzofuran-2-yl]but-2-enoic acidKi142.0 [1]
(E)-3-[4-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acidKi11.0 [1]
4-[(E)-C-(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-N-propoxycarbonimidoyl]benzoic acidKi61.0 [1]
(E)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]but-2-enoic acidKi261.0 [1]
4-(8,8,11,11-Tetramethyl-10,13-dihydro-9H-naphtho[2,3-c][1]benzazepin-6-yl)benzoic acidKi790.0 [1]
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acidIC5050.0 [1]
4-[(Z)-N-Methoxy-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi363.0 [1]
4-[(Z)-N-Methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi1000.0 [1]
4-[(E)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi623.0 [1]
(2E,4E,6Z)-7-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acidKi12.0 [1]
4-[(E)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi58.0 [1]
4-[(Z)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi1000.0 [1]
4-[(Z)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi1000.0 [1]
(2E,4E,6Z)-7-(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acidKi2.0 [1]
(2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-propylamino]-3-methylhexa-2,4-dienoic acidKi12.0 [1]
4-[(E)-N-(2-Aminoethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi1000.0 [1]
6-[(4-Chlorophenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC50870.0 [1]
6-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-[4-(trifluoromethyl)phenyl]sulfonylamino]pyridine-3-carboxylic acidIC50750.0 [1]
4-[5-(2-Chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acidIC506000.0 [1]
(E)-3-[4-(3,5-Ditert-butyl-2-heptoxyphenyl)-1-benzothiophen-2-yl]but-2-enoic acidKi12.0 [1]
(Z)-3-[7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acidKi64.5 [1]
(E)-3-[4-(3,5-Ditert-butyl-2-methylphenyl)-1-benzothiophen-2-yl]but-2-enoic acidKi33.0 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-propan-2-yl-5-thiophen-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi3.9 [1]
(2E,4E,6E)-7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acidKi24.4 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi7.4 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3,5-difluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi2.4 [1]
(2E,4E,6Z)-3-Methyl-7-[3-(1,1,2,2,2-pentafluoroethyl)-5-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acidKi9.9 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-phenyl-5-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi12.3 [1]
(2E,4E,6Z)-3-Methyl-7-[5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acidKi17.2 [1]
(2E,4E,6Z)-7-[2-Ethoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi8.5 [1]
4-[(E)-N-Hydroxy-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi3363.0 [1]
4-[(E)-N-(Carboxymethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi1000.0 [1]
4-[(E)-N-(Cyanomethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi14.0 [1]
4-[(E)-N-(2-Methylpropoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi91.0 [1]
(2E,4E)-3-Methyl-6-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)-propylamino]hexa-2,4-dienoic acidKi161.0 [1]
(2E,4E)-6-[(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-propylamino]-3-methylhexa-2,4-dienoic acidKi721.0 [1]
(2E,4E)-3-Methyl-5-[(2S)-1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)pyrrolidin-2-yl]penta-2,4-dienoic acidKi63.0 [1]
(2E,4E)-3-Methyl-5-[(2R)-1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)pyrrolidin-2-yl]penta-2,4-dienoic acidKi188.0 [1]
(2E,4E)-6-(3,5-Ditert-butyl-N-propylanilino)-3-methyl-6-oxohexa-2,4-dienoic acidKi605.0 [1]
(2E,4E)-6-(3,5-Ditert-butyl-N-methylanilino)-3-methylhexa-2,4-dienoic acidKi88.0 [1]
(2E,4E)-6-(3,5-Ditert-butyl-N-ethylanilino)-3-methylhexa-2,4-dienoic acidKi24.0 [1]
(2E,4E)-6-(3,5-Ditert-butyl-N-octylanilino)-3-methylhexa-2,4-dienoic acidKi126.0 [1]
(2E,4E)-6-[Butyl-(6-tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)amino]-3-methylhexa-2,4-dienoic acidKi60.0 [1]
(2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-propan-2-ylamino]-3-methylhexa-2,4-dienoic acidKi301.0 [1]
(2E,4E)-6-(3,5-Ditert-butyl-N-propylanilino)-3-methylhexa-2,4-dienoic acidKi34.0 [1]
(2E,4E)-6-(N-Benzyl-3,5-ditert-butylanilino)-3-methylhexa-2,4-dienoic acidKi238.0 [1]
(2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-(cyclopropylmethyl)amino]-3-methylhexa-2,4-dienoic acidKi105.0 [1]
(2E,4E)-6-[Ethyl-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)amino]-3-methylhexa-2,4-dienoic acidKi152.0 [1]
(2E,4E)-3-Methyl-6-[propyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]hexa-2,4-dienoic acidKi72.0 [1]
(2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-(3-methylbut-2-enyl)amino]-3-methylhexa-2,4-dienoic acidKi327.0 [1]
(2E,4E)-6-[Ethyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]-3-methylhexa-2,4-dienoic acidKi185.0 [1]
6-[[4-[[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenyl]methyl]-3,4,5-trihydroxyoxane-2-carboxylic acidKi2800.0 [1]
6-[Butylsulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC5010000.0 [1]
6-[Benzenesulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC5010000.0 [1]
6-[(4-Methylphenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC503000.0 [1]
6-[(4-Methoxyphenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC503900.0 [1]
6-[(4-Nitrophenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acidIC5010000.0 [1]
Chembl4174856IC5010000.0 [1]
4-[(3-Chloro-4-ethoxy-5-propan-2-yloxybenzoyl)amino]-2-methylbenzoic acidIC5010000.0 [1]
(2R,3S,4S,5S,6S)-6-[4-[[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidKi2800.0 [1]
[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]phosphonic acidKi12.0 [1]
(2E,4E,6Z)-7-[2-Butoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi8.2 [1]
4-[(Z)-(Hydroxyimino)(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-yl)methyl]benzoic acidKi5.0 [1]
(2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acidKi15.5 [1]
(2E,4E,6E)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(2-methylbutan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acidKi5.2 [1]
4-[(E)-N-Methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acidKi8.0 [1]
(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(4-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acidKi3.9 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Retinoid X receptor beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/retinoid-x-receptor-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Retinoid X receptor beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/retinoid-x-receptor-beta-inhibitors-ic50-ki.
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