 | Alitretinoin | IC50 | 4.0 [1] |
| Alitretinoin | Ki | 11.0 [1], 13.0 [2], 14.0 [3], 27.0 [4] |
 | Tretinoin | IC50 | 350.0 [1] |
| Tretinoin | Ki | 1.4 [1], 120.0 [2], 288.0 [3] |
 | Bexarotene | Ki | 8.3 [1], 29.0 [2], 75.0 [3] |
 | 6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid | Ki | 12.0 [1] |
 | (2E,4E,6Z)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 39.0 [1], 84.0 [2] |
 | Fenretinide | Ki | 6000.0 [1] |
 | Ttnpb | IC50 | 1000.0 [1] |
 | CID 11755040 | IC50 | 380.0 [1] |
 | 4-(2,18,18,21,21-Pentamethyl-2,14-diazapentacyclo[13.8.0.03,12.04,9.017,22]tricosa-1(15),3(12),4,6,8,10,13,16,22-nonaen-13-yl)benzoic acid | Ki | 1500.0 [1] |
 | (2E,4E,6Z)-3-Methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acid | Ki | 14.0 [1] |
 | 4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzothiazepin-12-yl)benzoic acid | Ki | 620.0 [1] |
 | 4-(5,7,7,10,10-Pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid | Ki | 1000.0 [1] |
 | 7-(3,5-Ditert-butylphenyl)-3-methylocta-2,4,6-trienoic acid | Ki | 320.0 [1] |
 | 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoic acid | Ki | 299.0 [1] |
 | 3-[5-(4-Chloro-3-methyl-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid | IC50 | 18000.0 [1] |
 | 4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl) benzoic acid | IC50 | 100.0 [1] |
 | 4-[(Z)-N-Hydroxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 209.0 [1] |
 | (2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 13.2 [1] |
 | 4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid | Ki | 290.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(2-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 10.9 [1] |
 | 4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid | IC50 | 10.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(3-fluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 21.0 [1] |
 | 4-(7,7,10,10-Tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzoxazepin-12-yl)benzoic acid | Ki | 2100.0 [1] |
 | 4-[(E)-C-(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-N-prop-2-enoxycarbonimidoyl]benzoic acid | Ki | 80.0 [1] |
 | 4-[(E)-N-Butoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 224.0 [1] |
 | (E)-3-[4-(3,5-Diisopropyl-2-propoxy-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid | Ki | 20.0 [1] |
 | 4-[(E)-C-(3-Bromo-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-N-hydroxycarbonimidoyl]benzoic acid | Ki | 57.0 [1] |
 | (Z)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | Ki | 49.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 20.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(3,3-difluoropropoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 37.0 [1] |
 | (E)-3-[4-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 20.0 [1] |
 | (E)-3-[7-[3,5-Di(propan-2-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | Ki | 334.0 [1] |
 | (E)-3-[4-(2-Ethoxy-3,5-diisopropyl-phenyl)-benzo[b]thiophen-2-yl]-but-2-enoic acid | Ki | 12.0 [1] |
 | 4-[(E)-C-(3,5,5,8,8-Pentamethyl-6,7-dihydronaphthalen-2-yl)-N-propoxycarbonimidoyl]benzoic acid | Ki | 57.0 [1] |
 | (E)-3-[7-[2-(2,2-Difluoroethoxy)-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]but-2-enoic acid | Ki | 500.0 [1] |
 | 4-(8,8,11,11-Tetramethyl-10,13-dihydro-9H-naphtho[2,3-c][1]benzazepin-6-yl)benzoic acid | Ki | 1000.0 [1] |
 | 4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid | IC50 | 10.0 [1] |
 | 4-[(Z)-N-Methoxy-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 558.0 [1] |
 | 4-[(Z)-N-Methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 238.0 [1] |
 | 4-[(E)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 445.0 [1] |
 | (2E,4E,6Z)-7-(3-Ethoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acid | Ki | 17.0 [1] |
 | 4-[(E)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 42.0 [1] |
 | 4-[(Z)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 467.0 [1] |
 | 4-[(Z)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 1000.0 [1] |
 | (2E,4E,6Z)-7-(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-methylocta-2,4,6-trienoic acid | Ki | 4.0 [1] |
 | (2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-propylamino]-3-methylhexa-2,4-dienoic acid | Ki | 10.0 [1] |
 | 4-[(E)-N-(2-Aminoethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 1000.0 [1] |
 | 6-[(4-Chlorophenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 4500.0 [1] |
 | 6-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)-[4-(trifluoromethyl)phenyl]sulfonylamino]pyridine-3-carboxylic acid | IC50 | 2700.0 [1] |
 | 4-[5-(2-Chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid | IC50 | 4900.0 [1] |
 | (E)-3-[4-(3,5-Ditert-butyl-2-heptoxyphenyl)-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 28.0 [1] |
 | (Z)-3-[7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-1-benzofuran-2-yl]-2-fluorobut-2-enoic acid | Ki | 28.0 [1] |
 | (E)-3-[4-(3,5-Ditert-butyl-2-methylphenyl)-1-benzothiophen-2-yl]but-2-enoic acid | Ki | 54.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-propan-2-yl-5-thiophen-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 5.6 [1] |
 | (2E,4E,6E)-7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 27.8 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.9 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(3,5-difluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 2.8 [1] |
 | (2E,4E,6Z)-3-Methyl-7-[3-(1,1,2,2,2-pentafluoroethyl)-5-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | Ki | 23.6 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3-phenyl-5-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 22.5 [1] |
 | (2E,4E,6Z)-3-Methyl-7-[5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-yl-2-propoxyphenyl]octa-2,4,6-trienoic acid | Ki | 27.6 [1] |
 | (2E,4E,6Z)-7-[2-Ethoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 7.7 [1] |
 | 4-[(E)-N-Hydroxy-C-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 5051.0 [1] |
 | 4-[(E)-N-(Carboxymethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 1000.0 [1] |
 | 4-[(E)-N-(Cyanomethoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 14.0 [1] |
 | 4-[(E)-N-(2-Methylpropoxy)-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 323.0 [1] |
 | (2E,4E)-3-Methyl-6-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)-propylamino]hexa-2,4-dienoic acid | Ki | 211.0 [1] |
 | (2E,4E)-6-[(3-Methoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-propylamino]-3-methylhexa-2,4-dienoic acid | Ki | 576.0 [1] |
 | (2E,4E)-3-Methyl-5-[(2S)-1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)pyrrolidin-2-yl]penta-2,4-dienoic acid | Ki | 100.0 [1] |
 | (2E,4E)-3-Methyl-5-[(2R)-1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)pyrrolidin-2-yl]penta-2,4-dienoic acid | Ki | 202.0 [1] |
 | (2E,4E)-6-(3,5-Ditert-butyl-N-propylanilino)-3-methyl-6-oxohexa-2,4-dienoic acid | Ki | 299.0 [1] |
 | (2E,4E)-6-(3,5-Ditert-butyl-N-methylanilino)-3-methylhexa-2,4-dienoic acid | Ki | 131.0 [1] |
 | (2E,4E)-6-(3,5-Ditert-butyl-N-ethylanilino)-3-methylhexa-2,4-dienoic acid | Ki | 35.0 [1] |
 | (2E,4E)-6-(3,5-Ditert-butyl-N-octylanilino)-3-methylhexa-2,4-dienoic acid | Ki | 221.0 [1] |
 | (2E,4E)-6-[Butyl-(6-tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)amino]-3-methylhexa-2,4-dienoic acid | Ki | 31.0 [1] |
 | (2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-propan-2-ylamino]-3-methylhexa-2,4-dienoic acid | Ki | 121.0 [1] |
 | (2E,4E)-6-(3,5-Ditert-butyl-N-propylanilino)-3-methylhexa-2,4-dienoic acid | Ki | 38.0 [1] |
 | (2E,4E)-6-(N-Benzyl-3,5-ditert-butylanilino)-3-methylhexa-2,4-dienoic acid | Ki | 207.0 [1] |
 | (2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-(cyclopropylmethyl)amino]-3-methylhexa-2,4-dienoic acid | Ki | 150.0 [1] |
 | (2E,4E)-6-[Ethyl-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)amino]-3-methylhexa-2,4-dienoic acid | Ki | 99.0 [1] |
 | (2E,4E)-3-Methyl-6-[propyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]hexa-2,4-dienoic acid | Ki | 110.0 [1] |
 | (2E,4E)-6-[(6-Tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)-(3-methylbut-2-enyl)amino]-3-methylhexa-2,4-dienoic acid | Ki | 309.0 [1] |
 | (2E,4E)-6-[Ethyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]-3-methylhexa-2,4-dienoic acid | Ki | 162.0 [1] |
 | 6-[Butylsulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 10000.0 [1] |
 | 6-[Benzenesulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 10000.0 [1] |
 | 6-[(4-Methylphenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 3800.0 [1] |
 | 6-[(4-Methoxyphenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 6600.0 [1] |
 | 6-[(4-Nitrophenyl)sulfonyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)amino]pyridine-3-carboxylic acid | IC50 | 10000.0 [1] |
 | (2R,3S,4S,5S,6S)-6-[4-[[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]amino]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | Ki | 6000.0 [1] |
 | [[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]phosphonic acid | Ki | 29.0 [1] |
 | (2E,4E,6Z)-7-[2-Butoxy-5-(1,1,2,2,2-pentafluoroethyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 45.7 [1] |
 | 4-[(Z)-(Hydroxyimino)(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-yl)methyl]benzoic acid | Ki | 5.0 [1] |
 | (2E,4E,6E)-7-[3,5-Ditert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 12.4 [1] |
 | (2E,4E,6E)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(2-methylbutan-2-yl)phenyl]-6-fluoro-3-methylocta-2,4,6-trienoic acid | Ki | 40.3 [1] |
 | 4-[(E)-N-Methoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid | Ki | 8.0 [1] |
 | (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-5-(4-fluorophenyl)-3-propan-2-ylphenyl]-3-methylocta-2,4,6-trienoic acid | Ki | 5.6 [1] |
 | (2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid | Ki | 6.0 [1] |
 | (2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid | Ki | 5.0 [1] |
 | 3-[[4-(4-Methylphenyl)-5-(naphthalen-1-yloxymethyl)-1,2,4-triazol-3-yl]sulfanyl]propanoic acid | IC50 | 17000.0 [1] |
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