Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	0.09 [1], 0.1 [2], 0.5 [3], 1.2 [4]
	4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide	IC50	3100.0 [1]
	Sunitinib	IC50	131.3 [1]
	Dasatinib	IC50	20000.0 [1]
	Dorsomorphin	IC50	210.0 [1]
	Doramapimod	IC50	30000.0 [1]
	4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine	IC50	10280.0 [1]
	Gsk-690693	IC50	1260.0 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	132.0 [1]
	CID 44219749	IC50	50000.0 [1]
	CID 11373846	IC50	780.0 [1]
	CID 59604787	IC50	10000.0 [1]
	1-(4-Methoxyphenyl)-3-[(2-oxo-3-indolyl)amino]thiourea	IC50	34900.0 [1]
	CID 11548023	IC50	398.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	61.0 [1]
	4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamide	IC50	620.0 [1]
	N-(1H-Indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamide	IC50	1100.0 [1]
	N-(7-Chloro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide	IC50	90.0 [1]
	6-Methyl-N-(3-methyl-2H-indazol-5-yl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide	IC50	1950.0 [1]
	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	IC50	35.0 [1]
	AKT Kinase Inhibitor	IC50	1.0 [1]
	4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine	IC50	2100.0 [1]
	3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	IC50	810.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	1580.0 [1]
	CID 25207521	IC50	290.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	3-[7-[4-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol	IC50	9710.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	5000.0 [1]
	5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	N-(1H-Indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide	IC50	740.0 [1]
	4-[7-(3-Aminopropoxy)-1-ethyl-4-phenyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	44.0 [1]
	4-(4-Fluorophenyl)-N-1H-indazol-5-yl-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide	IC50	1410.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	CID 11641672	IC50	510.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-phenyl-1,4-dihydropyrimidine-5-carboxamide	IC50	5300.0 [1]
	6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamide	IC50	10000.0 [1]
	3-(5-Cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine	IC50	311.0 [1]
	(5R)-4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one	IC50	20.0 [1]
	4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(3-fluorophenyl)methoxy]benzamide	IC50	5.4 [1]
	5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine	IC50	10000.0 [1]
	N-(4-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide	IC50	10000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole	IC50	10000.0 [1]
	N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amine	IC50	10000.0 [1]
	6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridine	IC50	10000.0 [1]
	4-[(4-Methyl-1H-indol-5-yl)amino]-2-[(E)-3-oxo-3-pyrrolidin-1-ylprop-1-enyl]thieno[2,3-b]pyridine-5-carbonitrile	IC50	50000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium	IC50	10000.0 [1]
	4-[7-(3-Aminopropoxy)-1-ethyl-4-(1H-pyrrol-2-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	13.0 [1]
	4-[7-(3-Aminopropoxy)-1-ethyl-4-(furan-3-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	71.0 [1]
	4-[7-(3-Aminopropoxy)-4-(2-cyclopropylethynyl)-1-ethylimidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	251.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	1259.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]but-3-yn-1-ol	IC50	6.0 [1]
	4-[7-(4-Aminobutoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	790.0 [1]
	4-[7-(2-Aminoethoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	500.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-[(3S)-3-amino-4-phenylbutoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	1560.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pyrrolidin-3-ylmethoxy)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	1990.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[3-[2-(4-methoxyphenyl)ethylamino]propoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	2510.0 [1]
	(2S)-3-[3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methylbut-1-ynyl)imidazo[4,5-c]pyridin-7-yl]oxypropylamino]propane-1,2-diol	IC50	500.0 [1]
	2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-phenylacetamide	IC50	780.0 [1]
	5-[(E)-4-[(3R)-3-Aminopiperidin-1-yl]but-1-enyl]-4-[(4-methyl-1H-indol-5-yl)amino]pyridine-3-carbonitrile	IC50	11000.0 [1]
	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	IC50	10000.0 [1]
	N-(2-Hydroxyethyl)-4-[3-[(Z)-(4-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-methylpyrrolo[2,3-b]pyridin-4-yl]benzamide	IC50	45.9 [1]
	3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	IC50	50000.0 [1]
	3-[[2-(Furan-2-yl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	IC50	50000.0 [1]
	3-[[(1R)-1-Phenylethyl]amino]-4-[(2-thiophen-3-ylpyridin-4-yl)amino]cyclobut-3-ene-1,2-dione	IC50	50000.0 [1]
	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	IC50	50000.0 [1]
	Tert-butyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate	IC50	50000.0 [1]
	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	IC50	50000.0 [1]
	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	IC50	50000.0 [1]
	CID 46179972	IC50	50000.0 [1]
	1-[4-[4-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(oxan-4-yl)-1,3,5-triazin-2-yl]phenyl]-3-[4-(4-propan-2-ylpiperazine-1-carbonyl)phenyl]urea	IC50	50000.0 [1]
	29-(Dimethylamino)-4,14,24,30-tetrazaheptacyclo[26.2.2.14,11.117,24.05,10.012,16.018,23]tetratriaconta-1(30),5,7,9,11(34),12(16),17(33),18,20,22,28,31-dodecaene-13,15-dione	IC50	1900.0 [1]
	5-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-1H-pyridin-2-one	IC50	2100.0 [1]
	Akt-IN-2	IC50	568.0 [1]
	N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamide	Ki	1000.0 [1]
	4-(5-(3,4-Dihydroxyphenyl)oxazol-2-ylamino)benzenesulfonamide	IC50	3400.0 [1]
	4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzene-1,2-diol	IC50	560.0 [1]
	4-[2-[4-[3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy]ethyl]morpholine	IC50	220.0 [1]
	4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]pyridin-2-amine	IC50	1100.0 [1]
	4-(5-(6-Oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylamino)benzenesulfonamide	IC50	10000.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-4-ylmethoxy)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol;2,2,2-trifluoroacetic acid	IC50	2510.0 [1]
	4-[7-(3-Aminopropoxy)-4-(3-aminoprop-1-ynyl)-1-ethylimidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;2,2,2-trifluoroacetic acid	IC50	251.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-piperidin-4-yloxyimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol;2,2,2-trifluoroacetic acid	IC50	3980.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	1000.0 [1]
	Chembl4126067	IC50	699.0 [1]
	Chembl4129817	IC50	272.0 [1]
	6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine	IC50	63000.0 [1]
	6-(2,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine	IC50	13000.0 [1]
	1-[(3-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;methanesulfonic acid	IC50	1.0 [1]
	3-Isopropyl-6-(4-phenyl-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	10000.0 [1]
	5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	N-[2-(4-Chloro-3-fluorophenyl)ethyl]-7-(oxan-4-ylamino)-1,6-naphthyridine-2-carboxamide	IC50	476.0 [1]
	(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	0.19 [1]
	2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine	IC50	1181.0 [1]
	6-(4-Fluorophenyl)sulfanyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	4253.0 [1]
	N-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-7-[(2-methylpyrazol-3-yl)amino]-1,6-naphthyridine-2-carboxamide	IC50	9.84 [1]
	N-[(S)-(3-Fluoro-4-methoxyphenyl)-(1-methylpyrazol-4-yl)methyl]-7-[[(2S)-1-hydroxypropan-2-yl]amino]-1,6-naphthyridine-2-carboxamide	IC50	37.8 [1]
	N-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-3-(oxan-4-ylamino)isoquinoline-6-carboxamide	IC50	14.8 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Ribosomal protein S6 kinase alpha 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-1-inhibitors-ic50-ki.
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