Ribosomal protein S6 kinase alpha 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Bisindolylmaleimide IX	IC50	10.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	1.0 [1]
	CID 53246941	IC50	1.1 [1]
	CID 59604787	IC50	10000.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	7.0 [1]
	2-(4-Toluidinomethyl)-1H-isoindole-1,3(2H)-dione	IC50	4300.0 [1]
	2-((4-Morpholinophenylamino)methyl)isoindoline-1,3-dione	IC50	790.0 [1]
	2-(((4-Methoxyphenyl)amino)methyl)isoindoline-1,3-dione	IC50	470.0 [1]
	N-(1-Methylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	9.0 [1]
	N-(3-Methyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	19.0 [1]
	N-(1-Methylpyrazol-4-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	11.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	940.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	7-(2-Methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	20.0 [1]
	29-(Dimethylamino)-4,14,24,30-tetrazaheptacyclo[26.2.2.14,11.117,24.05,10.012,16.018,23]tetratriaconta-1(30),5,7,9,11(34),12(16),17(33),18,20,22,28,31-dodecaene-13,15-dione	IC50	850.0 [1]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1.3 [1]
	N-[2-(Cyclopentylcarbamoyl)-1-methylimidazol-4-yl]-4,4-dimethyl-1-oxo-2,3-dihydropyrazino[1,2-a]indole-7-carboxamide	IC50	3.7 [1]
	N-(1-Ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1.1 [1]
	N-(6-Chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	12.0 [1]
	1-Oxo-N-[1-(pyridin-4-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1.9 [1]
	(5S)-N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	14.0 [1]
	N-(1H-Benzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	4.4 [1]
	N-(4-Chlorophenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	190.0 [1]
	4,4-Dimethyl-1-oxo-N-pyridin-3-yl-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	4600.0 [1]
	1-Oxo-N-(1-propan-2-ylpyrazolo[3,4-b]pyridin-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	53.0 [1]
	1-Oxo-N-(3-phenyl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	87.0 [1]
	1-Oxo-N-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	290.0 [1]
	N-(2-Methoxyphenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	400.0 [1]
	N-(2-Carbamoylphenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	21.0 [1]
	4,4-Difluoro-1-oxo-N-pyridin-3-yl-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1700.0 [1]
	1-Oxo-N-quinolin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	70.0 [1]
	N-[6-Chloro-1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	20.0 [1]
	N-(1H-Imidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	25.5 [1]
	1-Oxo-N-pyridin-3-ylspiro[3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-4,1'-cyclopropane]-8-carboxamide	IC50	430.0 [1]
	1-Oxo-N-pyridin-3-ylspiro[3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-4,1'-cyclobutane]-8-carboxamide	IC50	3300.0 [1]
	N-(1,3-Benzoxazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	370.0 [1]
	N-[1-(Cyclohexylmethyl)pyrazol-4-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	7.4 [1]
	1-Oxo-N-pyridin-4-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	39.0 [1]
	N-(1-Methylimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	2200.0 [1]
	1-Oxo-N-(1H-pyrazol-4-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	43.0 [1]
	1-Oxo-N-quinolin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	34.0 [1]
	N-(3-Cyclopropyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	18.0 [1]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-4,4-dimethyl-1-oxo-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	27.0 [1]
	N-[3-(1H-Imidazol-5-yl)phenyl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	52.0 [1]
	N-(1-Methylpyrazol-3-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	540.0 [1]
	1-Oxo-N-(1-propan-2-ylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	20.0 [1]
	1-Oxo-N-(1-phenylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	61.0 [1]
	N-(3-Ethylimidazo[4,5-b]pyridin-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	4.4 [1]
	1-Oxo-N-(3-propan-2-yl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	26.0 [1]
	N-(3-Chlorophenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	270.0 [1]
	5-Methyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	41.0 [1]
	(4R,5S)-4,5-Dimethyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1100.0 [1]
	1-Oxo-N-(1H-pyrazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	93.0 [1]
	N-(2-Chlorophenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	6000.0 [1]
	1-Oxo-N-pyridin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	220.0 [1]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	21.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	10000.0 [1]
	2-[(4-Ethoxyanilino)methyl]-5-nitroisoindole-1,3-dione	IC50	2830.0 [1]
	7-(2-Fluoro-6-Methoxyphenyl)-N-(3,4,5-Trimethoxyphenyl)-1,3-Benzoxazol-2-Amine	IC50	20.0 [1]
	7-(1h-Benzimidazol-7-Yl)-N-(3,4,5-Trimethoxyphenyl)-1,3-Benzoxazol-2-Amine	IC50	4.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-[4-methoxy-3-[(3S)-pyrrolidin-3-yl]oxyphenyl]-1,3-benzoxazol-2-amine	IC50	10.0 [1]
	7-(5-Fluoro-2-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	40.0 [1]
	7-(2-Methoxy-4-methylphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	40.0 [1]
	7-(1H-Indazol-7-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	50.0 [1]
	N-(3,4-Dimethoxyphenyl)-7-(2-fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	70.0 [1]
	N-(3,5-Dimethoxyphenyl)-7-(2-fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	210.0 [1]
	1-N-[7-(2-Fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-yl]-4-methoxybenzene-1,3-diamine	IC50	220.0 [1]
	7-(2-Fluorophenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	220.0 [1]
	3-[[7-(2-Fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-yl]amino]benzenesulfonamide	IC50	340.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-(3-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	410.0 [1]
	7-(2-Ethoxy-6-fluorophenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	490.0 [1]
	7-(2,5-Dimethyl-1H-imidazol-4-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	560.0 [1]
	N-Cyclohexyl-7-(2-fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	620.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-(6-methoxypyridin-2-yl)-1,3-benzoxazol-2-amine	IC50	620.0 [1]
	N-(3-Ethoxyphenyl)-7-(2-fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	730.0 [1]
	7-(2-Fluoro-6-propan-2-yloxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	970.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-phenyl-1,3-benzoxazol-2-amine	IC50	1000.0 [1]
	7-(2-Methoxy-5-methylphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	1100.0 [1]
	7-(2,6-Dimethoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	1200.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-(4-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	1400.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-1,3-benzoxazol-2-amine	IC50	2800.0 [1]
	7-(2-Fluoro-6-methoxyphenyl)-N-(oxan-4-yl)-1,3-benzoxazol-2-amine	IC50	3200.0 [1]
	7-[2-(Trifluoromethoxy)phenyl]-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	4000.0 [1]
	7-[2-(1H-Pyrazol-4-yl)phenyl]-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine	IC50	9300.0 [1]
	1-[4-(Dimethylamino)-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone	IC50	15.0 [1]
	N-[2-[(4-Methoxyanilino)methyl]-1,3-dioxoisoindol-5-yl]benzamide	IC50	2160.0 [1]
	N-[2-[(4-Ethoxyanilino)methyl]-1,3-dioxoisoindol-4-yl]benzamide	IC50	1340.0 [1]
	N-[2-[(4-Ethoxyanilino)methyl]-1,3-dioxoisoindol-5-yl]benzamide	IC50	4580.0 [1]
	5-Amino-2-[(4-methoxyanilino)methyl]isoindole-1,3-dione	IC50	590.0 [1]
	N-[2-[(4-Morpholin-4-ylanilino)methyl]-1,3-dioxoisoindol-5-yl]benzamide	IC50	1010.0 [1]
	4-Amino-2-[(4-methoxyanilino)methyl]isoindole-1,3-dione	IC50	3530.0 [1]
	2-[(4-Methoxy-N-methylanilino)methyl]isoindole-1,3-dione	IC50	3500.0 [1]
	N-[2-[(4-Methoxyanilino)methyl]-1,3-dioxoisoindol-4-yl]benzamide	IC50	990.0 [1]
	2-[[4-(Diethylamino)-2-methylanilino]methyl]isoindole-1,3-dione	IC50	860.0 [1]
	2-{[(4-Ethoxyphenyl)amino]methyl}-1H-isoindole-1,3(2H)-dione	IC50	590.0 [1]
	(3S,4R)-N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-3,4-dimethyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	13.7 [1]
	(4R)-N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	0.7 [1]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-4-methyl-1-oxo-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	1.3 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ribosomal protein S6 kinase alpha 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Ribosomal protein S6 kinase alpha 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-2-inhibitors-ic50-ki.
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