Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone	IC50	15.0 [1]
	[(2S,3S,4S,5R,6S)-4-Acetyloxy-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-5-hydroxy-2-methyloxan-3-yl] acetate	IC50	89.0 [1], 370.0 [2], 583.0 [3], 990.0 [4]
	N-(1-Methylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	9.0 [1], 200.0 [2]
	N-(3-Methyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	19.0 [1], 200.0 [2]
	N-(1-Methylpyrazol-4-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	11.0 [1], 790.0 [2]
	2,6-Difluoro-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol	IC50	4.0 [1], 210.0 [2]
	4,4'-(1h-Pyrazole-3,4-Diyl)diphenol	IC50	20.0 [1], 24.0 [2], 2800.0 [3]
	2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol	IC50	5.0 [1], 340.0 [2]
	3-(4-Amino-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol	IC50	430000.0 [1], 1200000.0 [2], 30000000.0 [3]
	CID 53246941	IC50	1.0 [1], 20.0 [2]
	1-Oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	730.0 [1], 10000.0 [2]
	1-Oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	240.0 [1], 1940.0 [2]
	4-Methyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1200.0 [1], 4890.0 [2]
	3-(2-Furylmethylene)-1,3-dihydro-2H-indol-2-one	IC50	3470.0 [1], 7760.0 [2]
	4-Methyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	170.0 [1], 1630.0 [2]
	4-[4-(4-Methylpiperazin-1-yl)phenyl]-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	240.0 [1], 2400.0 [2]
	2,6-Difluoro-4-[4-(4-morpholin-4-ylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol	IC50	2.0 [1], 50.0 [2]
	5-(3,5-Difluoro-4-methoxyphenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine	IC50	500.0 [1], 20000.0 [2]
	5-[4-(Difluoromethyl)phenyl]-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine	IC50	800.0 [1], 18100.0 [2]
	2,6-Difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol	IC50	0.3 [1], 54.0 [2]
	2,6-Difluoro-4-[4-(4-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol	IC50	2.0 [1], 232.0 [2]
	5-(3,5-Difluorophenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine	IC50	38.0 [1], 6000.0 [2]
	5-[4-[4-(4-Methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-amine	IC50	810.0 [1], 7200.0 [2]
	5-(2-Fluoropyridin-4-yl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine	IC50	1100.0 [1], 20000.0 [2]
	5-(4-Fluorophenyl)-4-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine	IC50	1900.0 [1], 20000.0 [2]
	4,4-Dimethyl-1-oxo-N-pyridin-3-yl-2,3-dihydropyrazino[1,2-a]indole-7-carboxamide	IC50	210.0 [1], 1550.0 [2]
	N-(1-Ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1.0 [1], 40.0 [2]
	N-(6-Chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	12.0 [1], 90.0 [2]
	1-Oxo-N-[1-(pyridin-4-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	2.0 [1], 90.0 [2]
	(5S)-N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	14.0 [1], 100.0 [2]
	N-(1H-Benzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	4.0 [1], 10000.0 [2]
	(3Z)-3-[[5-(2-Nitrophenyl)-1H-pyrazol-4-yl]methylidene]-1H-indol-2-one	IC50	1.6 [1], 500.0 [2]
	(3S,4R)-3,4-Dimethyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	45.0 [1], 840.0 [2]
	1-Oxo-N-(1-propan-2-ylpyrazolo[3,4-b]pyridin-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	53.0 [1], 840.0 [2]
	1-Oxo-N-(3-phenyl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	86.0 [1], 360.0 [2]
	1-Oxo-N-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	290.0 [1], 1930.0 [2]
	N-(2-Carbamoylphenyl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	21.0 [1], 560.0 [2]
	1-Oxo-N-quinolin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	68.0 [1], 1130.0 [2]
	N-[6-Chloro-1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	20.0 [1], 160.0 [2]
	N-(1H-Imidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	26.0 [1], 290.0 [2]
	N-(1,3-Benzoxazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	367.0 [1], 10000.0 [2]
	N-(5-Chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	6.0 [1], 130.0 [2]
	N-[1-(Cyclohexylmethyl)pyrazol-4-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	7.0 [1], 120.0 [2]
	1-Oxo-N-pyridin-4-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	34.0 [1], 620.0 [2]
	1-Oxo-N-(1H-pyrazol-4-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	43.0 [1], 10000.0 [2]
	1-Oxo-N-quinolin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	34.0 [1], 340.0 [2]
	1-Oxo-N-[1-(pyridin-2-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	10.0 [1], 460.0 [2]
	N-(3-Cyclopropyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	18.0 [1], 250.0 [2]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-4,4-dimethyl-1-oxo-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	27.0 [1], 290.0 [2]
	1-Oxo-N-(1-propan-2-ylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	20.0 [1], 180.0 [2]
	1-Oxo-N-(1-phenylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	61.0 [1], 1000.0 [2]
	N-(3-Ethylimidazo[4,5-b]pyridin-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	4.0 [1], 80.0 [2]
	1-Oxo-N-(3-propan-2-yl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	26.0 [1], 460.0 [2]
	N-(3-Benzyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	13.0 [1], 130.0 [2]
	5-Methyl-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	41.0 [1], 890.0 [2]
	1-Oxo-N-pyridin-2-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	220.0 [1], 2630.0 [2]
	1-Oxo-N-(pyridin-3-ylmethyl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	10000.0 [1]
	N-[1-[3-(Dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	21.0 [1], 200.0 [2]
	2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine	IC50	607.1 [1], 1230.0 [2]
	Staurosporine	IC50	0.5 [1]
	Sunitinib	IC50	183.9 [1]
	Dasatinib	IC50	20000.0 [1]
	Tofacitinib	IC50	10000.0 [1]
	Bisindolylmaleimide IX	IC50	10.0 [1]
	(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one	Ki	2000.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	1.0 [1]
	A-674563	Ki	580.0 [1]
	JNK Inhibitor V	IC50	10000.0 [1]
	JNK Inhibitor VIII	Ki	7400.0 [1]
	CID 59604787	IC50	10000.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	13.0 [1]
	2-[Ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol	IC50	180.0 [1]
	2-Amino[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione	IC50	9990.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	7400.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	7400.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	7368.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	Khk-IN-1	IC50	40000.0 [1]
	1-Oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	9100.0 [1]
	Tert-butyl N-[3-[3-[4-(2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate	IC50	640.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	7400.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	7400.0 [1]
	2-(4-Aminophenyl)-4-methyl-1H-benzo[d]imidazol-5-amine	IC50	320.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	3300.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	7400.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	83.0 [1]
	(E)-Methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)acrylate	IC50	250.0 [1]
	3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine	IC50	1306.0 [1]
	N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine	IC50	360.0 [1]
	2-((4-Morpholinophenylamino)methyl)isoindoline-1,3-dione	IC50	950.0 [1]
	3-Methyl-1-oxo-N-pyridin-3-yl-3,4-dihydro-2H-pyrazino[1,2-a]indole-7-carboxamide	IC50	350.0 [1]
	1-Oxo-N-(1,3-thiazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	2200.0 [1]
	4-(Aminomethyl)-1-oxo-N-pyridin-3-yl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide	IC50	1800.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	IC50	4000.0 [1]
	3-[(1R)-1-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]ethyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine	IC50	330.0 [1]
	Tert-butyl (E)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanoprop-2-enoate	IC50	7.0 [1]
	(E)-3-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-propan-2-ylprop-2-enamide	IC50	5.0 [1]
	(E)-3-(4-Amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)acrylonitrile	IC50	750.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Ribosomal protein S6 kinase alpha 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-3-inhibitors-ic50-ki.
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