Ribosomal protein S6 kinase alpha 5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[1-Ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	0.5 [1], 8.0 [2]
	4-(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	3.0 [1]
	4-(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	1.5 [1], 1.8 [2]
	4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine	IC50	3.0 [1]
	4-[1-Ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	21.0 [1]
	4-(1-Piperidin-4-ylimidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine	IC50	17.0 [1]
	4-(1-Phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	6.0 [1], 11.0 [2]
	Staurosporine	IC50	1.4 [1]
	Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-	IC50	8300.0 [1]
	N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	IC50	120.0 [1]
	Fasudil	IC50	5000.0 [1]
	Tofacitinib	IC50	10000.0 [1]
	Bisindolylmaleimide IX	IC50	8.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Gsk-690693	IC50	7940.0 [1]
	RepSox	IC50	16000.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	2340.0 [1]
	Amg-458	IC50	100000.0 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	49.0 [1]
	JNK Inhibitor V	IC50	10000.0 [1]
	4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide	IC50	25000.0 [1]
	Pyrimidone, 22	IC50	100000.0 [1]
	2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One	IC50	200000.0 [1]
	2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one	IC50	100000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	4-(1-Ethyl-1H-benzimidazol-2-yl)-1,2,5-oxadiazol-3-amine	IC50	140.0 [1]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	10000.0 [1]
	2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one	IC50	200000.0 [1]
	4-(1-Ethyl-6-fluoro-1H-benzoimidazol-2-yl)-furazan-3-ylamine	IC50	2120.0 [1]
	4-(1-Methyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	126.0 [1]
	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]imidazo[4,5-c]pyridine-7-carboxamide	IC50	15.0 [1]
	4-[1-Ethyl-7-(piperazin-1-ylcarbonyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	47.0 [1]
	4-(4-Ethoxy-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	174.0 [1]
	4-(3-Ethyl-3H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	1540.0 [1]
	4-(1,4-Diethyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	229.0 [1]
	4-(1-Ethyl-4-pyrrolidin-1-yl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	2240.0 [1]
	4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	4.0 [1]
	4-[1-(3-Dimethylamino-propyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	617.0 [1]
	Lck Inhibitor	IC50	100000.0 [1]
	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	IC50	14.0 [1]
	6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid	IC50	200000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	1892.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[1-(3-hydroxypropyl)pyrrolo[2,3-b]pyridin-3-yl]pyrrole-2,5-dione	IC50	10000.0 [1]
	6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one	Ki	728.5 [1]
	4-Methyl-3-[2-(methylamino)quinazolin-6-yl]-N-[2-(1-methylpiperidin-4-yl)oxy-5-(trifluoromethyl)phenyl]benzamide	IC50	25000.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	8000.0 [1]
	CID 44397277	IC50	1.4 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	4-(4-Fluorophenyl)-N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]phthalazin-1-amine	IC50	25000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	4-(1-Ethyl-5-fluoro-1H-benzoimidazol-2-yl)-furazan-3-ylamine	IC50	38.0 [1]
	[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-benzoimidazol-5-yl]-methanol	IC50	974.0 [1]
	2-(4-Amino-furazan-3-yl)-1-ethyl-1H-benzoimidazol-5-ol	IC50	17.0 [1]
	1-[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-benzoimidazol-5-yl]-ethanone	IC50	4390.0 [1]
	5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	4-(1-Ethyl-5-methoxy-1H-benzoimidazol-2-yl)-furazan-3-ylamine	IC50	1200.0 [1]
	5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	3-[(2R,3As,3bR,5aS,9aS,9bR,11aS)-3b,6,6,9a,11a-pentamethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e][1]benzofuran-2-yl]-2-hydroxy-2H-furan-5-one	IC50	4000.0 [1]
	4-[7-(3-Aminopropoxy)-1-ethyl-4-phenyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	1000.0 [1]
	4-[1-Ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	1.0 [1]
	3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine	IC50	20.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	990.0 [1]
	3-[(E)-2-[(1R,4Ar,4bS,8aS,10aR)-4b,8,8,10a-tetramethyl-2-methylidene-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-1-yl]ethenyl]-2-hydroxy-2H-furan-5-one	IC50	4000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	94.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	1000.0 [1]
	2-(4-Amino-furazan-3-yl)-3-ethyl-3H-benzoimidazol-5-ol	IC50	258.0 [1]
	8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-one	Ki	1000.0 [1]
	1,2,5-Oxadiazol-3-amine, 4-(3H-imidazo[4,5-c]pyridin-2-yl)-	IC50	1960.0 [1]
	3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyridin-2-ol	IC50	10000.0 [1]
	2-Methyl-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide	IC50	100000.0 [1]
	N-[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-6-[2-(isoquinolin-5-ylsulfonylamino)ethylamino]hexanamide	IC50	81.28 [1]
	2-(2-Phenylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one	IC50	146000.0 [1]
	2-[[(1R,4Ar,4bS,8aS,10aS)-4b,8,8,10a-tetramethyl-2-methylidene-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-1-yl]methyl]-3-(hydroxymethyl)-2H-furan-5-one	IC50	4000.0 [1]
	3-[2-[(1R,4Ar,4bS,8aS,10aS)-4b,8,8,10a-tetramethyl-2-methylidene-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	IC50	4000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole	IC50	10000.0 [1]
	N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amine	IC50	10000.0 [1]
	6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridine	IC50	10000.0 [1]
	7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic Acid	IC50	200000.0 [1]
	2-(4-Fluoroanilino)-5-[5-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-3-methylpyrimidin-4-one	IC50	52000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium	IC50	10000.0 [1]
	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3R)-3-aminopyrrolidin-1-yl]methanone	IC50	3.0 [1]
	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperidin-3-yl)-1H-imidazo[4,5-c]pyridine-7-carboxamide	IC50	11.0 [1]
	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperidin-4-yl)-1H-imidazo[4,5-c]pyridine-7-carboxamide	IC50	13.0 [1]
	4-[7-(3-Aminopropoxy)-1-ethyl-4-(furan-3-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	162.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	15850.0 [1]
	4-[7-(4-Aminobutoxy)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	15800.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pyrrolidin-3-ylmethoxy)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	10000.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[3-[2-(4-methoxyphenyl)ethylamino]propoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	19900.0 [1]
	4-(1-Ethyl-4-methoxy-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	209.0 [1]
	1-Ethyl-2-phenyl-1H-imidazo[4,5-c]pyridine	IC50	10000.0 [1]
	4-(1-Ethyl-4-phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	813.0 [1]
	2-(4-Chloro-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridine	IC50	10000.0 [1]
	4-[7-[(4-Aminopiperidin-1-yl)methyl]-1-ethylimidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	3.0 [1]
	4-[1-(1-Aminobutyl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	13.0 [1]
	4-(4-Chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan-3-ylamine	IC50	4.0 [1]
	4-(1-Ethylimidazo[4,5-c]pyridin-2-yl)-1,5-dimethylpyrazol-3-amine	IC50	1520.0 [1]
	4-(1-Ethyl-4-phenoxyimidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ribosomal protein S6 kinase alpha 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Ribosomal protein S6 kinase alpha 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ribosomal-protein-s6-kinase-alpha-5-inhibitors-ic50-ki.
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