S-methyl-5-thioadenosine phosphorylase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	MT-DADMe-ImmA	Ki	0.08 [1], 0.09 [2], 0.53 [3]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol	Ki	1.0 [1], 26.0 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(phenylmethoxymethyl)pyrrolidin-3-ol	Ki	42.0 [1], 85.0 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-propylpyrrolidin-3-ol	Ki	3.0 [1], 22.0 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(3-chlorophenyl)sulfanylmethyl]pyrrolidin-3-ol	Ki	0.27 [1], 2.0 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(cyclohexylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.37 [1], 0.76 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(ethylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.03 [1], 0.65 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(pyridin-4-ylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.16 [1], 2.0 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(methoxymethyl)pyrrolidin-3-ol	Ki	8.0 [1], 14.0 [2]
	1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(benzylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.7 [1], 1.4 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(4-chlorophenyl)sulfanylmethyl]pyrrolidin-3-ol	Ki	0.01 [1], 0.36 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(butylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.11 [1], 0.28 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(4-fluorophenyl)sulfanylmethyl]pyrrolidin-3-ol	Ki	0.16 [1], 0.81 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(phenylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.17 [1], 1.5 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(propylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.12 [1], 1.3 [2]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(propan-2-ylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.26 [1], 0.9 [2]
	1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(methylsulfanylmethyl)pyrrolidin-3-ol	Ki	0.09 [1], 1.7 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(4-methylphenyl)sulfanylmethyl]pyrrolidine-3,4-diol;hydrochloride	Ki	0.64 [1], 4.4 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(propylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	0.21 [1], 4.0 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(phenylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	1.0 [1], 3.6 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(4-fluorophenyl)sulfanylmethyl]pyrrolidine-3,4-diol;hydrochloride	Ki	2.0 [1], 6.4 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(3-methylphenyl)sulfanylmethyl]pyrrolidine-3,4-diol;hydrochloride	Ki	0.63 [1], 1.39 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(2-fluoroethylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	3.2 [1], 20.0 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(4-chlorophenyl)sulfanylmethyl]pyrrolidine-3,4-diol;hydrochloride	Ki	0.17 [1], 0.58 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(ethylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	0.27 [1], 9.2 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(2-hydroxyethylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	14.0 [1], 56.0 [2]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	1.0 [1], 26.0 [2]
	(2S,3S,4R,5S)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol	Ki	1.0 [1]
	(2R,3S)-2-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino)-4-(methylthio)butane-1,3-diol	Ki	5.2 [1]
	[1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3-(methylsulfanylmethyl)azetidin-3-yl]methanol	Ki	140.0 [1]
	7-({3-[(Methylsulfanyl)methyl]azetidin-1-yl}methyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine	Ki	2.0 [1]
	(2S,3R)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl-methylamino]-4-methylsulfanylbutane-2,3-diol	Ki	368.0 [1]
	(2S)-2-[[(1S)-1-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-methylsulfanylpropan-1-ol	Ki	130.0 [1]
	2-[[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]methyl]-3-methylsulfanylpropan-1-ol	Ki	10.0 [1]
	(2R,3S)-3-[[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl-methylamino]methyl]-4-methylsulfanylbutane-1,2-diol	Ki	12.0 [1]
	1-[(7-Amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)methyl]-4-(benzylsulfanylmethyl)pyrrolidin-3-ol	Ki	55.0 [1]
	1-[(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(3-phenylpropyl)pyrrolidin-3-ol	Ki	2000.0 [1]
	(2S,3S,4R,5S)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	IC50	1.2 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(methoxymethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	134.0 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(naphthalen-1-ylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	90.0 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylpyrrolidine-3,4-diol;hydrochloride	Ki	720.0 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(benzylsulfanylmethyl)pyrrolidine-3,4-diol;hydrochloride	Ki	26.0 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-propylpyrrolidine-3,4-diol;hydrochloride	Ki	44.0 [1]
	2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(3-chlorophenyl)sulfanylmethyl]pyrrolidine-3,4-diol;hydrochloride	Ki	6.4 [1]
	(3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-ethylpyrrolidin-3-ol	Ki	0.7 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-butylpyrrolidin-3-ol	Ki	0.55 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(2-methylpropyl)pyrrolidin-3-ol	Ki	1.7 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-cyclopropylpyrrolidin-3-ol	Ki	2.1 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-cyclopentylpyrrolidin-3-ol	Ki	2.6 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(cyclohexylmethyl)pyrrolidin-3-ol	Ki	14.0 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-phenylpyrrolidin-3-ol	Ki	8.0 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-ethenylpyrrolidin-3-ol	Ki	3.2 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-prop-2-enylpyrrolidin-3-ol	Ki	3.0 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-ethynylpyrrolidin-3-ol	Ki	31.0 [1]
	(3S,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(triazol-1-yl)pyrrolidin-3-ol	Ki	59.0 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(3-benzylsulfanylpropyl)pyrrolidin-3-ol	Ki	71.0 [1]
	(3S,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-ethylpyrrolidin-3-ol	Ki	34.0 [1]
	(3R,4S)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(2-ethylbutyl)pyrrolidin-3-ol	Ki	18.0 [1]
	(2R,3R)-2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-4-methylsulfanylbutane-1,3-diol	Ki	87.0 [1]
	2-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino)-2-(methylthiomethyl)propane-1,3-diol	Ki	34.0 [1]
	(S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino)-3-(methylthio)propan-2-ol	Ki	602.0 [1]
	(2R,3R)-2-[[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl-methylamino]methyl]-4-methylsulfanylbutane-1,3-diol	Ki	105.0 [1]
	(2R)-2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-3-methylsulfanylpropan-1-ol	Ki	4.4 [1]
	(2S)-2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-3-methylsulfanylpropan-1-ol	Ki	34.0 [1]
	2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-3-methylsulfanylpropan-1-ol	Ki	12.0 [1]
	(2S,3R)-2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-4-methylsulfanylbutane-1,3-diol	Ki	87.0 [1]
	(2S,3S)-2-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]-4-methylsulfanylbutane-1,3-diol	Ki	34.0 [1]
	(3S,4R)-1-[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(methylsulfanylmethyl)pyrrolidin-3-ol	Ki	750.0 [1]
	(2R,3S)-3-[[(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methylamino]methyl]-4-methylsulfanylbutane-1,2-diol	Ki	34.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ S-methyl-5-thioadenosine phosphorylase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/s-methyl-5-thioadenosine-phosphorylase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ S-methyl-5-thioadenosine phosphorylase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/s-methyl-5-thioadenosine-phosphorylase-inhibitors-ic50-ki.
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