 | 2-(Morpholin-4-yl)-benzo[h]chromen-4-one | IC50 | 100000.0 [1] |
 | CID 46244454 | IC50 | 5.0 [1], 50.0 [2], 61.0 [3] |
 | 4-{4-[1-(Methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole | IC50 | 8.0 [1], 290.0 [2], 360.0 [3] |
 | 4-[2-(6-Fluoro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 15.0 [1], 130.0 [2], 440.0 [3] |
 | 4-{4-[1-(Methylsulfonyl)cyclopropyl]-6-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)pyrimidin-2-yl}-1H-indole | IC50 | 7.0 [1], 110.0 [2], 350.0 [3] |
 | 4-[2-(1H-Benzimidazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 180.0 [1], 6200.0 [2], 8900.0 [3] |
 | N-Methyl-4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide | IC50 | 140.0 [1], 15000.0 [2], 16500.0 [3] |
 | N-Methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 5.61 [1], 6.0 [2], 7.05 [3], 9.0 [4] |
 | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | IC50 | 10000.0 [1], 100000.0 [2] |
 | 3-Amino-6-[4-[1-(dimethylamino)propan-2-ylsulfonyl]phenyl]-N-phenylpyrazine-2-carboxamide | IC50 | 12.0 [1], 420.0 [2] |
| 3-Amino-6-[4-[1-(dimethylamino)propan-2-ylsulfonyl]phenyl]-N-phenylpyrazine-2-carboxamide | Ki | 6.0 [1] |
 | Schisandrin B | IC50 | 7200.0 [1], 7300.0 [2] |
 | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one | IC50 | 10000.0 [1], 100000.0 [2] |
 | Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane | IC50 | 4.0 [1], 74.0 [2] |
 | CID 118502708 | IC50 | 6160.0 [1], 6200.0 [2] |
 | 4-[2-(1H-Indol-5-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine | IC50 | 1700.0 [1], 30000.0 [2] |
 | 3-Amino-n,6-diphenylpyrazine-2-carboxamide | IC50 | 620.0 [1], 2500.0 [2] |
 | Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane | IC50 | 14.0 [1], 86.0 [2] |
 | 4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]-1H-indole | IC50 | 30.0 [1], 1100.0 [2] |
 | (3R)-3-Methyl-4-[6-[1-[(R)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 16.0 [1], 180.0 [2] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxetan-3-yl)imidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 1-(3-Methoxycyclobutyl)-3-methyl-8-[6-[3-(methylamino)propoxy]pyridin-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 4370.0 [1], 4400.0 [2] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-[(3S)-oxan-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 29000.0 [1], 30000.0 [2] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-1-(3-hydroxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 1-(3-Methoxycyclobutyl)-3-methyl-8-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 22800.0 [1], 24000.0 [2] |
 | 8-[6-[3-(Dimethylamino)propoxy]-2-fluoropyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 8-[6-[3-(Dimethylamino)propoxy]-2-fluoropyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 1-(3-Methoxycyclobutyl)-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 2600.0 [1], 24700.0 [2] |
 | 8-[6-[3-(Dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-[(3R)-oxan-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 22800.0 [1], 23000.0 [2] |
 | 8-[6-[3-(Azetidin-1-yl)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 24000.0 [1], 24400.0 [2] |
 | 7-Fluoro-3-methyl-1-[(3S)-oxan-3-yl]-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 30000.0 [1] |
 | 7-Fluoro-3-methyl-1-(oxan-4-yl)-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one | IC50 | 27100.0 [1], 29000.0 [2] |
 | N-Methyl-1-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]benzimidazol-2-amine | IC50 | 10.0 [1] |
 | N-Methyl-4-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-amine | IC50 | 10.0 [1] |
 | 2-[(10S,14R)-14-Methyl-4-[5-(methylamino)-1H-pyrrolo[2,3-b]pyridin-4-yl]-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-6-yl]propan-2-ol | IC50 | 10.0 [1] |
 | N-Methyl-1-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]imidazol-2-amine | IC50 | 10.0 [1], 100.0 [2] |
 | 7-Fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one | IC50 | 28000.0 [1], 30000.0 [2] |
 | 7-Fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 90.0 [1], 5100.0 [2] |
 | 4-Fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 10.0 [1], 130.0 [2] |
 | 4-Methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 270.0 [1], 5300.0 [2] |
 | 5-Methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 550.0 [1], 15000.0 [2] |
 | 4-[6-(1-Methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 5.0 [1], 85.0 [2] |
 | (3R)-3-Methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 2.0 [1], 12.0 [2] |
 | 4-[6-(1-Methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 37.0 [1], 350.0 [2] |
 | N-[1-[4-[(3R)-3-Methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-yl]acetamide | IC50 | 14.0 [1], 17.0 [2] |
 | N-Methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 2.0 [1], 8.0 [2] |
 | 2-Amino-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazole-5-carbonitrile | IC50 | 4000.0 [1], 30000.0 [2] |
 | 1-[4-(1-Methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]benzimidazol-2-amine | IC50 | 3.0 [1], 51.0 [2] |
 | 5-Fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 2.0 [1], 35.0 [2] |
 | (3R)-3-Methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 5.0 [1], 100.0 [2] |
 | 5-Chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 21.0 [1], 870.0 [2] |
 | (3R)-3-Methyl-4-[6-[1-[(S)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 11.0 [1], 90.0 [2] |
 | 4-Chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 17.0 [1], 5300.0 [2] |
 | 1-[4-[(3R)-3-Methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 1.0 [1], 15.0 [2] |
 | 4-[4-(3,6-Dihydro-2H-pyran-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]-1H-indole | IC50 | 18.0 [1], 270.0 [2] |
 | 6-Fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine | IC50 | 8.0 [1], 120.0 [2] |
 | 6-Methyl-4-{4-[1-(methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole | IC50 | 8.0 [1], 490.0 [2] |
 | 2-Methyl-4-{4-[1-(methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole | IC50 | 28.0 [1], 2500.0 [2] |
 | 6-Methoxy-4-{4-[1-(methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole | IC50 | 23.0 [1], 800.0 [2] |
 | 4-[4-(1-Methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carbonitrile | IC50 | 66.0 [1], 1500.0 [2] |
 | 4-[2-(6-Chloro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 16.0 [1], 720.0 [2] |
 | 4-{4-[4-(Methylsulfonyl)piperidin-4-yl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole | IC50 | 9.0 [1], 420.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)pyrimidin-4-yl]morpholine | IC50 | 4.0 [1], 180.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(1-propan-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 13.0 [1], 770.0 [2] |
 | (3S)-4-[2-(1H-Indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine | IC50 | 34.0 [1], 3700.0 [2] |
 | 3-Amino-6-[4-(azetidine-1-carbonyl)phenyl]-N-phenylpyrazine-2-carboxamide | IC50 | 100.0 [1], 1000.0 [2] |
 | 3-Amino-6-(4-(dimethylcarbamoyl)phenyl)-n-phenylpyrazine-2-carboxamide | IC50 | 54.0 [1], 2000.0 [2] |
 | 3-Amino-N-phenyl-6-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazine-2-carboxamide | IC50 | 54.0 [1], 1400.0 [2] |
 | 3-Amino-N-phenyl-6-[4-(piperidine-1-carbonyl)phenyl]pyrazine-2-carboxamide | IC50 | 26.0 [1], 6500.0 [2] |
 | 3-Amino-6-[3-chloro-4-(dimethylcarbamoyl)phenyl]-N-phenylpyrazine-2-carboxamide | IC50 | 48.0 [1], 12000.0 [2] |
 | 3-Amino-6-(4-methylsulfinylphenyl)-N-phenylpyrazine-2-carboxamide | IC50 | 56.0 [1], 5400.0 [2] |
 | 3-Amino-6-(4-ethylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide | IC50 | 12.0 [1], 1500.0 [2] |
 | 3-Amino-N-phenyl-6-(4-propan-2-ylsulfonylphenyl)pyrazine-2-carboxamide | IC50 | 8.0 [1], 1000.0 [2] |
 | 3-Amino-N-phenyl-6-(4-propylsulfonylphenyl)pyrazine-2-carboxamide | IC50 | 14.0 [1], 2000.0 [2] |
 | 3-Amino-6-(4-butan-2-ylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide | IC50 | 10.0 [1], 1600.0 [2] |
 | 3-Amino-6-(4-tert-butylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide | IC50 | 6.0 [1], 1000.0 [2] |
 | 3-Amino-6-[4-(4-hydroxybutan-2-ylsulfonyl)phenyl]-N-phenylpyrazine-2-carboxamide | IC50 | 8.0 [1], 380.0 [2] |
 | 3-Amino-6-[4-[(3R)-oxolan-3-yl]sulfonylphenyl]-N-phenylpyrazine-2-carboxamide | IC50 | 10.0 [1], 460.0 [2] |
 | (S)-Ceralasertib | IC50 | 21.82 [1], 240.0 [2] |
 | 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-phenyl-4,5-dihydroisoxazol-5-yl)pyrazin-2-amine | Ki | 16.0 [1], 90.0 [2] |
 | 3-[3-[4-(Methylaminomethyl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine | Ki | 16.0 [1], 90.0 [2] |
 | 4-[2-(1H-Indol-6-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine | IC50 | 1500.0 [1], 30000.0 [2] |
 | 4-[2-(1H-Indol-7-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine | IC50 | 180.0 [1], 30000.0 [2] |
 | 4-[2-(1-Methylindol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine | IC50 | 3300.0 [1], 30000.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(2-methylsulfonylpropan-2-yl)pyrimidin-4-yl]morpholine | IC50 | 3.0 [1], 280.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(1-methyl-4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine | IC50 | 61.0 [1], 3700.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-[1-(oxan-4-ylsulfonyl)cyclopropyl]pyrimidin-4-yl]morpholine | IC50 | 33.0 [1], 2800.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(1-piperidin-4-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 46.0 [1], 2900.0 [2] |
 | 4-[6-[1-(Benzenesulfonyl)cyclopropyl]-2-(1H-indol-4-yl)pyrimidin-4-yl]morpholine | IC50 | 5.0 [1], 590.0 [2] |
 | 4-[2-(1H-Indol-4-yl)-6-(1-pyridin-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 33.0 [1], 2000.0 [2] |
 | 4-[6-(1-Methylsulfonylcyclopropyl)-2-phenylpyrimidin-4-yl]morpholine | IC50 | 360.0 [1], 30000.0 [2] |
 | 3-[4-(1-Methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]aniline | IC50 | 1200.0 [1], 30000.0 [2] |
 | 4-[4-(1-Methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1,3-dihydroindol-2-one | IC50 | 120.0 [1], 16000.0 [2] |
 | 4-[2-(1H-Indazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 130.0 [1], 13000.0 [2] |
 | 4-[2-(3-Methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 14000.0 [1], 30000.0 [2] |
 | 4-[2-(7-Methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine | IC50 | 220.0 [1], 6300.0 [2] |
 | 4-[4-(1-Methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-2-carboxamide | IC50 | 1100.0 [1], 30000.0 [2] |
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