Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Vemurafenib	IC50	2.1 [1], 950.0 [2]
	Sorafenib	IC50	7.1 [1]
	Dabrafenib	IC50	26.0 [1]
	LY-3009120	IC50	44.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	194.0 [1]
	4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(1-methylpiperidin-4-yl)oxy-3-(trifluoromethyl)phenyl]benzamide	IC50	43.4 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	17.8 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-piperidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	57.4 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[[1-[6-[3-(dimethylamino)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]-4-methylbenzamide	IC50	34.1 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[(1-methylpiperidin-4-yl)methylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	42.2 [1]
	4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-[(1-methylpiperidin-4-yl)methoxy]-3-(trifluoromethyl)phenyl]benzamide	IC50	37.6 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	46.9 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	25.3 [1]
	4-Methyl-3-[[1-[6-(methylamino)pyrimidin-4-yl]cyclopropanecarbonyl]amino]-N-[4-(3-morpholin-4-ylpropoxy)-3-(trifluoromethyl)phenyl]benzamide	IC50	40.7 [1]
	N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	25.3 [1]
	N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-[2-(4-methylpiperazin-1-yl)ethylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	30.1 [1]
	5-[[(1S,1Ar,6bS)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one	IC50	5.6 [1]
	N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-3-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(4-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2,5-difluorobenzenesulfonamide	IC50	100.0 [1]
	N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,6-difluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-3-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]benzenesulfonamide	IC50	10.0 [1]
	N-[3-(5-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluorophenyl]benzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]pyridine-3-sulfonamide	IC50	100.0 [1]
	N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamide	IC50	100.0 [1]
	N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]pyridine-3-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-[4-(methanesulfonamido)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide	IC50	10.0 [1]
	5-[3-[2,6-Difluoro-3-(propylsulfonylamino)benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-(6-propylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-(6-pyrrolidin-1-ylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-[6-(2-morpholin-4-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-(6-oxo-1H-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-[6-(3-morpholin-4-ylpropoxy)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-(5-methoxy-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl]-2-fluorobenzenesulfonamide	IC50	10.0 [1]
	N-[2,4-Difluoro-3-[5-(3-methoxyprop-1-ynyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[3-(5-Ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[2-Fluoro-3-[5-(2-methoxypyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[3-[5-[2-(Dimethylamino)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2-fluorophenyl]propane-1-sulfonamide	IC50	10.0 [1]
	N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]-2,5-difluorobenzenesulfonamide	IC50	10.0 [1]
	1-(3,3-Dimethylbutyl)-3-[4-fluoro-3-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]urea	IC50	31.0 [1]
	1-(3-Fluoro-3-methylbutyl)-3-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]urea	IC50	120.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 55 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-a-raf-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Serine/threonine-protein kinase A-Raf Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-a-raf-inhibitors-ic50-ki.
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