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Serine/threonine-protein kinase AKT Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
StaurosporineIC5011.0 [1]
Akt inhibitor VIIIIC5058.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineIC502.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineKi2.0 [1]
Gsk-690693IC502.0 [1]
Gsk-690693Ki1.0 [1]
2-[4-[2-(2-Aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamideIC502500.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-6-cyclopentylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC502100.0 [1]
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideIC501800.0 [1]
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideKi4500.0 [1]
N-[[4-[5-(3-Acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamideIC5044.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC505600.0 [1]
2-[4-[5-(3-Acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamideIC5049.0 [1]
2-[4-[2-(2-Aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamideIC5065.0 [1]
N-[[4-[5-(3-Acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC50140.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC50740.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-6-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC5091.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-6-bromoimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC502500.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-5-phenylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC50410.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-6-phenylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamideIC50680.0 [1]
2-[4-[5-(3-Acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-(3-fluorophenyl)acetamideIC50120.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamideIC50340.0 [1]
N-[[4-[2-(2-Aminopyridin-3-yl)-6-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamideIC5054.0 [1]
(2S)-1-N-(5-Isoquinolin-6-yl-1,3,4-thiadiazol-2-yl)-3-[4-(trifluoromethyl)phenyl]propane-1,2-diamineIC50247.0 [1]
(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-AmineIC500.16 [1], 2.5 [2]
(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-AmineKi0.16 [1]
MedermycinIC50149.0 [1], 30400.0 [2], 38500.0 [3]
2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amineIC503400.0 [1], 250000.0 [2]
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamineIC5014.0 [1], 360.0 [2], 3000.0 [3]
A-674563IC5014.0 [1], 125.0 [2], 100000.0 [3]
A-674563Ki11.0 [1]
Merck-22-6IC50138.0 [1], 253.0 [2], 527.0 [3]
3-[1-[[4-(5-Methyl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC50760.0 [1]
3-[1-[[4-(5-Methyl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneKi760.0 [1]
1-(1-{[4-(3-Phenylquinoxalin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC50290.0 [1], 295.0 [2]
4-Amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamideIC5020000.0 [1], 25000.0 [2]
4-Amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamideKi50000.0 [1]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-2-chloropyridin-3-yl}isoquinolineIC501.8 [1], 3000.0 [2], 5700.0 [3]
7-[4-[[4-(4-Aminopyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amineIC5014.0 [1], 295.0 [2]
N,N-Dimethyl-2-[4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanamineIC504.0 [1], 10.0 [2]
N-Methyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-amineIC506.0 [1], 20.0 [2], 20.3 [3]
7-[4-[[4-(6-Fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amineIC5018.0 [1], 277.0 [2]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinolin-3-amineIC503.4 [1], 200.0 [2], 930.0 [3]
PictilisibIC5028.0 [1], 37.0 [2], 46.0 [3]
Frenolicin BIC50198.0 [1], 313.0 [2]
4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamideIC506300.0 [1], 10000.0 [2]
4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamideKi2400.0 [1]
(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanolIC5010.0 [1], 38.0 [2], 1100.0 [3]
(11R,15R,17R)-17-Methyl-12,16-dioxatetracyclo[8.7.0.03,8.011,15]heptadeca-1(10),3,5,7-tetraene-2,9,13-trioneIC50150.0 [1], 280.0 [2]
3-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxylic acidIC50166.0 [1]
3-[(2S)-2-Amino-3-phenylpropoxy]-5-[(E)-2-(pyridin-4-yl)ethenyl]pyridineIC50690.0 [1]
2-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxylic acidIC50240.0 [1]
(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-AmineIC501.0 [1], 500.0 [2]
(2R)-2-Amino-3-(4-fluorophenyl)-1-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-oneIC503.0 [1], 160.0 [2]
1-(2-Aminophenyl)-3-[[4-(2-methylsulfanyl-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methylamino]propan-1-oneIC5015.0 [1], 78.0 [2]
4-Spiro[2H-indole-3,4'-piperidine]-1-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrileIC502.0 [1], 2.4 [2], 50.0 [3]
9-Phenyl-8-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[3,4-f][1,6]naphthyridineIC504.0 [1], 5.0 [2]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-fluoroisoquinolineIC503.5 [1], 2300.0 [2]
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olIC502.0 [1], 3.0 [2], 400.0 [3]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)decanamideIC5010000.0 [1], 15000.0 [2]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)decanamideKi21800.0 [1]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)-2-(2-(2-methoxyethoxy)ethoxy)acetamideIC5050000.0 [1]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)-2-(2-(2-methoxyethoxy)ethoxy)acetamideKi50000.0 [1]
N-[5-Chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methylphenyl]-N',N'-dimethylethane-1,2-diamineIC50371.0 [1], 9026.0 [2]
N-[3-[4-(3-Bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-chloro-2-methylphenyl]-N',N'-dimethylethane-1,2-diamineIC5053.0 [1], 4285.0 [2]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)acetamideIC5050000.0 [1]
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)acetamideKi50000.0 [1]
(2S)-1-N-[5-(3-Methyl-2H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-[4-(trifluoromethyl)phenyl]propane-1,2-diamineIC505.5 [1], 333.0 [2], 357.0 [3]
(2S)-1-N-[5-(1H-Indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-[4-(trifluoromethyl)phenyl]propane-1,2-diamineIC506.0 [1], 154.0 [2], 444.0 [3]
MK-2206IC508.0 [1], 10.0 [2]
CapivasertibIC503.0 [1], 34.0 [2]
IpatasertibIC505.0 [1], 157.0 [2]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC500.66 [1], 3.0 [2]
UprosertibIC502.0 [1], 18.0 [2]
N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamideIC506.3 [1]
(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-oneIC504500.0 [1]
(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-oneKi3900.0 [1]
(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-oneIC509.0 [1], 12.0 [2]
(Z)-3-((1H-Pyrrol-2-yl)methylene)indolin-2-oneIC502300.0 [1], 3000.0 [2]
(1S)-1-Methyl-2-[5-[2-(4-pyridyl)vinyl]-6-chloro-3-pyridyloxy]ethanamineIC505290.0 [1]
[(2R)-2-Methoxy-3-octadecoxypropyl] [(1R,2S,3S,4R,6R)-2,3,4,6-tetrahydroxycyclohexyl] hydrogen phosphateIC501500.0 [1]
5-[5-[(1,3-Dioxoindan-2-ylidene)methyl]-2-furyl]-2-hydroxy-benzoic acidIC5025100.0 [1]
5-[5-[(1,3-Dioxoindan-2-ylidene)methyl]-2-furyl]-2-hydroxy-benzoic acidKi20800.0 [1]
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-CarboxamideIC504430.0 [1]
AKT Kinase InhibitorIC502.0 [1], 1130.0 [2]
Akt inhibitorIC500.5 [1], 310.0 [2]
3-(3-Iodobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5028.0 [1], 10000.0 [2]
[(2R)-2-Methoxy-3-octadecoxypropyl] [(1R,2S,3S,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(hydroxymethyl)cyclohexyl] carbonateIC505000.0 [1], 32000.0 [2]
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-1H-indazoleIC501.5 [1]
N-[4-[5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]phenyl]acetamideIC50227.0 [1]
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-6-chloropyridin-3-yl}isoquinolineIC5012.0 [1]
(E)-3-(4-Bromophenyl)-N-[2-[5-[(E)-2-pyridin-4-ylethenyl]pyridin-3-yl]oxyethyl]prop-2-en-1-amineIC5032250.0 [1]
3-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-6-(pyridin-4-yl)quinolineIC50300.0 [1]
3-[1-[[4-(6-Oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC503029.0 [1]
3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-3-phenyl-1H-pyrazin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC5020000.0 [1], 21200.0 [2]
(2S)-2-Amino-3-(1H-indol-3-yl)-N-[5-[(E)-2-pyridin-4-ylethenyl]pyridin-3-yl]propanamideIC50278.0 [1]
5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-N-pyridin-4-ylpyridine-3-carboxamideIC501659.0 [1], 2020.0 [2]
3-N-[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]-5-N-isoquinolin-5-ylpyridine-3,5-diamineIC50270.0 [1]
(2S)-3-(1H-Indol-3-yl)-1-N-(5-isoquinolin-5-yloxypyridin-3-yl)propane-1,2-diamineIC50210.0 [1]
3-[1-[[4-(6-Oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-oneIC501500.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase AKT Inhibitors (IC50, Ki)." AAT Bioquest, Inc.15 Apr2024https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024April 15). Quest Database™ Serine/threonine-protein kinase AKT Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt-inhibitors-ic50-ki.
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