Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	0.64 [1], 5.0 [2], 10.0 [3]
	Akt inhibitor VIII	IC50	2119.0 [1], 2200.0 [2], 10000.0 [3]
	Gsk-690693	IC50	9.0 [1]
	Gsk-690693	Ki	13.0 [1]
	2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amine	IC50	50000.0 [1], 250000.0 [2]
	Merck-22-6	IC50	7200.0 [1], 10000.0 [2]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	IC50	35.0 [1]
	1-(1-{[4-(3-Phenylquinoxalin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one	IC50	27000.0 [1], 50000.0 [2]
	3-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxylic acid	IC50	3200.0 [1]
	2-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxylic acid	IC50	50000.0 [1]
	(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	774.0 [1]
	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	IC50	354.0 [1]
	3-[1-[[4-[3-Phenyl-7-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	1613.0 [1]
	3-[1-[[4-[3-Phenyl-6-(2H-tetrazol-5-yl)quinoxalin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	1228.0 [1]
	4-[1-Ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	398.0 [1]
	N-[2-(Diethylamino)ethyl]-2-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxamide	IC50	7400.0 [1], 8000.0 [2]
	N-[(2S)-1-Amino-3-(2,4-dichlorophenyl)propan-2-yl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide	IC50	2.6 [1], 3.0 [2]
	N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	IC50	200.0 [1]
	MK-2206	IC50	65.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Neflamapimod	IC50	5000.0 [1]
	Capivasertib	IC50	8.0 [1]
	4-Amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	IC50	15.0 [1]
	(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-Amine	IC50	51.0 [1]
	Ipatasertib	IC50	8.0 [1]
	Afuresertib	IC50	1.58 [1]
	Aminofurazanyl-azabenzimidazole 6n	IC50	1510.0 [1]
	4-[1-Ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	646.0 [1]
	JNK Inhibitor VIII	Ki	9500.0 [1]
	(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol	IC50	50.0 [1]
	CID 11634725	Ki	4000.0 [1]
	H-89 Dihydrochloride	IC50	662.0 [1]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	17378.01 [1]
	CID 59604787	IC50	10000.0 [1]
	2-(4-Fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-a]pyridine	IC50	10000.0 [1]
	3-[1-[[4-(5-Methyl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamide	IC50	10000.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-6-(pyrrolidin-1-ylmethyl)imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	22.0 [1]
	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]imidazo[4,5-c]pyridine-7-carboxamide	IC50	1410.0 [1]
	4-[1-Ethyl-7-(piperazin-1-ylcarbonyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine	IC50	1549.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	9500.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	9500.0 [1]
	[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]-[(3S)-3-aminopyrrolidin-1-yl]methanone	IC50	1290.0 [1]
	Akt inhibitor	IC50	12.0 [1]
	3-(3-Iodobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	10000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	7157.0 [1]
	(2s)-1-{[6-Furan-3-Yl-5-(3-Methyl-2h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-(1h-Indol-3-Yl)propan-2-Amine	IC50	1.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	N-[(2S)-1-Amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide	IC50	7.6 [1]
	3-[1-[[4-(6-Oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-3-phenyl-1H-pyrazin-2-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	21870.0 [1]
	3-[1-[[4-(6-Oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]-2-chloropyridin-3-yl}isoquinoline	IC50	73.0 [1]
	3-[1-[[4-(5-Methyl-6-oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	33100.0 [1]
	3-[1-[[4-[5-(2-Methylpropyl)-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	3-[1-[[4-(7-Phenyl-1H-pyrazolo[3,4-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	2400.0 [1]
	7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrile	Ki	4890.0 [1]
	7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile	Ki	10000.0 [1]
	N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamide	Ki	10000.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	9500.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	9500.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	9500.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	9500.0 [1]
	N-Methyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-amine	IC50	2474.0 [1]
	4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	IC50	57.0 [1]
	6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinolin-3-amine	IC50	76.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	3-[1-[[4-[5-[(4-Hydroxyphenyl)methyl]-6-oxo-2-phenyl-1H-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3R)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	9.0 [1]
	(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	14.6 [1]
	(S)-1-(5-(3-Methyl-7-propyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine	IC50	10000.0 [1]
	(2S)-1-[6-(Furan-3-yl)-5-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-5-yl)pyridin-3-yl]oxy-3-(1H-indol-3-yl)propan-2-amine	IC50	10.0 [1]
	5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	IC50	1100.0 [1]
	N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide	IC50	12.0 [1]
	N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide	IC50	1000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	10000.0 [1]
	Tilfrinib	IC50	10000.0 [1]
	3-[1-[[4-(5-Butan-2-yl-6-oxo-2-phenyl-1H-pyrazin-3-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	3-[1-[[4-(5-Butan-2-yl-6-oxo-3-phenyl-1H-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one	IC50	50000.0 [1]
	(R)-2-Amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-yl)piperazin-1-yl)propan-1-one	IC50	179.0 [1]
	4-[1-Ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine	IC50	380.0 [1]
	N-(4-Fluorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	3000.0 [1]
	N-(2,4-Dichlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	990.0 [1]
	N-(2,4-Dichlorophenethyl)-5-(2-(ethylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	1500.0 [1]
	5-[2-(Methylamino)pyrimidin-4-yl]-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamide	IC50	19000.0 [1]
	N-(4-Fluorobenzyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	4700.0 [1]
	N-(3-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	5400.0 [1]
	5-(2-(Methylamino)pyrimidin-4-yl)-N-phenethylthiophene-2-carboxamide	IC50	5000.0 [1]
	N-(2-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	2900.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	N-(2,4-Dichlorophenethyl)-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide	IC50	610.0 [1]
	N-[(2S)-1-(2,4-Dichlorophenyl)-3-hydroxypropan-2-yl]-5-[2-(methylamino)pyrimidin-4-yl]thiophene-2-carboxamide	IC50	280.0 [1]
	N-(4-Chlorophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	1100.0 [1]
	N-(3-(4-Fluorophenyl)propyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	18000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	N-(4-Bromophenethyl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide	IC50	2600.0 [1]
	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-6-[(2R)-2-amino-3-phenylpropoxy]-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	3.0 [1]
	4-[6-(Aminomethyl)-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol	IC50	70.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase AKT3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-akt3-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan