Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tozasertib	IC50	31.0 [1]
	Tozasertib	Ki	18.0 [1]
	Staurosporine	IC50	1.8 [1]
	Alisertib	IC50	396.0 [1]
	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide	IC50	130.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	4000.0 [1]
	Danusertib	IC50	79.0 [1]
	Danusertib	Ki	79.0 [1]
	Azd-1152hqpa	IC50	0.3 [1], 0.37 [2], 1.0 [3], 17.0 [4]
	Azd-1152hqpa	Ki	1.0 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	IC50	3.5 [1], 5.0 [2], 32.0 [3]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	Ki	0.38 [1]
	(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine	IC50	290.0 [1], 350.0 [2]
	Ilorasertib	IC50	2.0 [1], 7.0 [2], 7.87 [3]
	2,4-Bisanilinopyrimidine, 10	IC50	55.0 [1], 3400.0 [2], 27000.0 [3], 50000.0 [4]
	4-[[2-[4-[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]-N-(2-chlorophenyl)benzamide	IC50	57.0 [1], 3700.0 [2], 25000.0 [3], 27000.0 [4]
	Barasertib	IC50	0.37 [1], 1.0 [2]
	Barasertib	Ki	0.37 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	2.7 [1], 3.0 [2], 30.0 [3]
	Hesperadin	IC50	3.0 [1], 250.0 [2]
	N-(2,6-Diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide	IC50	135.0 [1]
	PF-03814735	IC50	5.0 [1], 11.0 [2], 50.0 [3]
	1-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}-3-[3-(Trifluoromethyl)phenyl]urea	IC50	14.0 [1]
	1-Phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea	IC50	120.0 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(2-methylpropyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	1.0 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(2-methylpropyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	Ki	1.0 [1]
	2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide	IC50	1.0 [1], 270.0 [2]
	2-[3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide	Ki	1.0 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	1.0 [1], 45.0 [2]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	Ki	1.0 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	1.0 [1], 18.0 [2]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	Ki	1.0 [1]
	N-(3-Fluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	2.0 [1], 290.0 [2]
	N-(3-Fluorophenyl)-2-[3-[[7-[3-[2-hydroxyethyl(propyl)amino]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	Ki	2.0 [1]
	N-[4-[4-(4-Tert-butylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	IC50	11.0 [1]
	N-[4-[4-(4-Tert-butylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	Ki	0.8 [1], 11.0 [2]
	Unii-LM7NL857V1	IC50	5.0 [1], 100.0 [2], 310.0 [3]
	2-Chloro-N-[4-({5-Fluoro-2-[(4-Hydroxyphenyl)amino]pyrimidin-4-Yl}amino)phenyl]benzamide	IC50	1400.0 [1], 12000.0 [2], 30000.0 [3]
	N-(2-Chlorophenyl)-4-[[5-fluoro-2-(4-hydroxyanilino)pyrimidin-4-yl]amino]benzamide	IC50	1900.0 [1], 25000.0 [2], 30000.0 [3]
	N-Cyclopropyl-4-[[5-fluoro-2-(4-hydroxyanilino)pyrimidin-4-yl]amino]benzamide	IC50	3800.0 [1], 25000.0 [2], 30000.0 [3]
	4-[6-Amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide	IC50	11.0 [1], 1000.0 [2], 10000.0 [3]
	2-(1,3-Dimethyl-1H-pyrazole-4-yl)-6-chloro-7-[4-(phenylcarbamoyl)phenoxy]-3H-imidazo[4,5-b]pyridine	IC50	12710.0 [1], 24650.0 [2], 76840.0 [3]
	Orantinib	IC50	35.0 [1], 47.0 [2]
	Entrectinib	IC50	338.0 [1], 1000.0 [2]
	MK-5108	IC50	10.0 [1], 14.0 [2]
	1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}urea	IC50	31.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	IC50	19.0 [1]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	9.2 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	17000.0 [1], 25000.0 [2]
	N-(4-Chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	IC50	18.0 [1]
	2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-Carboxamide	IC50	15848.93 [1], 20000.0 [2]
	4-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-phenylthieno[2,3-d]pyrimidine	IC50	7.67 [1], 141.1 [2]
	CID 9916282	IC50	7.0 [1]
	N-[5-[(2S)-2-Methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide	IC50	630.0 [1]
	N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	IC50	20.0 [1]
	N-[4-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	Ki	20.0 [1]
	2-({2-[(4-Carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acid	IC50	31.0 [1], 5400.0 [2]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamide	IC50	14.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamide	Ki	14.0 [1]
	N-(3-Fluorophenyl)-2-[3-[[7-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	2.0 [1], 680.0 [2]
	Methyl 3-[[5-[4-(3,5-dimethoxyphenyl)triazol-1-yl]-2-hydroxybenzoyl]amino]benzoate	IC50	3580.0 [1], 5940.0 [2]
	N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)quinazolin-2-ylthio)phenyl)acetamide	Ki	27.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide	IC50	8.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide	Ki	8.0 [1]
	N-[4-[4-(4-Ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	IC50	25.0 [1]
	N-[4-[4-(4-Ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	Ki	25.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide	IC50	18.0 [1]
	N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(piperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide	Ki	18.0 [1]
	N-[4-[4-(4-Cyclopropylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	IC50	9.5 [1]
	N-[4-[4-(4-Cyclopropylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]propanamide	Ki	9.5 [1]
	N-[5-[(2R)-2-Hydroxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide	IC50	48.0 [1]
	4-(4-Methylpiperazin-1-yl)-N-[5-[(2R)-2-phenylpropanoyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide	IC50	99.0 [1]
	N-[5-[(2R)-2-Fluoro-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide	IC50	300.0 [1]
	4-(4-Methylpiperazin-1-yl)-N-[5-[(2S)-2-phenylpropanoyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]benzamide	IC50	1210.0 [1]
	N-(4-(Benzo[d]thiazol-2-yl)phenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	135.0 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	IC50	7.5 [1]
	N-(2,3-Difluorophenyl)-2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]acetamide	Ki	1.0 [1]
	N-[3-Methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-1H-benzimidazol-2-amine	IC50	77.0 [1], 80.0 [2]
	1-[4-[4-Amino-7-(1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea	IC50	8.0 [1], 8.44 [2]
	N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine	IC50	9.0 [1], 10.0 [2]
	3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine	IC50	13.0 [1]
	N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine	IC50	13.0 [1]
	N-(4-(Benzo[d]thiazol-2-yl)-2-methylphenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	3700.0 [1]
	4-Amino-N-[4-[(3-fluorophenyl)carbamoylamino]phenyl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide	IC50	3.0 [1], 9.0 [2]
	6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-Amine	IC50	3162.28 [1], 3480.0 [2]
	Ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylate	IC50	1.0 [1], 34.0 [2]
	3-Methyl-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine	IC50	13.0 [1]
	2-[(3S,4S)-3-(4-Fluorophenoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide	IC50	44.0 [1]
	N~4~-(2-Chlorophenyl)-N~2~-[4-(1h-Tetrazol-5-Yl)phenyl]pyrimidine-2,4-Diamine	IC50	226.0 [1], 10000.0 [2]
	N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamide	IC50	93.0 [1]
	N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide	IC50	38.0 [1]
	4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-ol	IC50	398.11 [1]
	4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-ol	Ki	398.11 [1]
	1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[3-[[ethyl(methyl)amino]methyl]phenyl]urea	IC50	140.4 [1], 10000.0 [2]
	1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(4-hydroxypiperidin-1-yl)methyl]phenyl]urea	IC50	78.9 [1], 132.6 [2]
	N-{4-[(6-Oxo-5,6-Dihydrobenzo[c][1,8]naphthyridin-1-Yl)amino]phenyl}benzamide	IC50	1.0 [1], 208.0 [2]
	1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-[2-[(dimethylamino)methyl]phenyl]urea	IC50	23.7 [1], 45.0 [2]
	1-[4-[2-[(5-Chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl]phenyl]-3-phenylurea	IC50	66.3 [1], 191.2 [2]
	3-[Dideuterio-(3,3-difluoropyrrolidin-1-yl)methyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;hydrochloride	IC50	13.0 [1], 63.0 [2]
	N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amine;hydrochloride	IC50	13.0 [1], 45.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Serine/threonine-protein kinase Aurora-B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-aurora-b-inhibitors-ic50-ki.
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