Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sorafenib	IC50	38.0 [1]
	Sorafenib	Ki	22.0 [1], 38.0 [2]
	Vemurafenib	IC50	31.0 [1]
	Dabrafenib	IC50	1.0 [1]
	CID 46209401	IC50	8.3 [1]
	2,6-Difluoro-N-(3-Methoxy-2h-Pyrazolo[3,4-B]pyridin-5-Yl)-3-[(Propylsulfonyl)amino]benzamide	IC50	5.01 [1]
	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide	IC50	44.0 [1]
	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide	Ki	2.6 [1], 4.0 [2]
	(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	IC50	0.13 [1], 0.17 [2], 1000.0 [3]
	(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	Ki	0.13 [1], 0.17 [2], 0.19 [3]
	(NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine	IC50	0.16 [1], 290.0 [2]
	(NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine	Ki	0.16 [1], 0.3 [2]
	2,6-Difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide	IC50	42.0 [1]
	Raf265(chir-265)	IC50	40.0 [1]
	AZ-628	IC50	27.0 [1]
	B-Raf inhibitor 1	IC50	2.0 [1]
	B-Raf inhibitor 1	Ki	1.0 [1]
	2,6-Difluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide	IC50	18.0 [1]
	6-Chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide	IC50	1.7 [1]
	N-(6-Aminopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide	IC50	920.0 [1]
	Staurosporine	IC50	4.5 [1], 5.0 [2], 5.03 [3], 8.7 [4], 14.0 [5]
	LY-3009120	IC50	5.8 [1], 15.0 [2], 31.0 [3], 37.0 [4], 5800.0 [5]
	2,6-Difluoro-N-(1h-Imidazo[4,5-B]pyridin-6-Yl)-3-[(Propylsulfonyl)amino]benzamide	IC50	61.0 [1], 2386.0 [2], 2400.0 [3], 3000.0 [4]
	N-(3-Bromo-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide	IC50	3.4 [1], 3.98 [2], 39.0 [3], 190.0 [4]
	2,6-Difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamide	IC50	3000.0 [1], 3880.0 [2], 3900.0 [3], 6700.0 [4], 6730.0 [5]
	N-(2-Methoxyethyl)-4-[(6-Pyridin-4-Ylquinazolin-2-Yl)amino]benzamide	IC50	77.0 [1], 77.62 [2], 190.0 [3], 890.0 [4], 30000.0 [5]
	4-Amino-N-[6-chloro-2-fluoro-3-(3-fluoropropylsulfonylamino)phenyl]thieno[3,2-d]pyrimidine-7-carboxamide	IC50	0.18 [1], 2.0 [2], 4.6 [3], 22.0 [4]
	Encorafenib	IC50	0.3 [1], 2.0 [2]
	4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine	IC50	270.0 [1], 592.0 [2], 990.0 [3]
	Furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone	IC50	200.0 [1], 1800.0 [2]
	N-(3-Bromo-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide	IC50	4.0 [1], 44.0 [2], 260.0 [3]
	2,6-Difluoro-N-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide	IC50	12.0 [1], 86.0 [2], 830.0 [3]
	1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[2-fluoro-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea	IC50	40.0 [1], 110.0 [2]
	1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[2-methylsulfanyl-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea	IC50	56.0 [1], 76.0 [2]
	2,6-Difluoro-3-(propylsulfonylamino)-N-pyrazolo[1,5-a]pyrimidin-6-ylbenzamide	IC50	247.0 [1], 488.0 [2]
	2,6-Difluoro-N-(2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide	IC50	4.6 [1], 7.0 [2], 12.0 [3], 17.0 [4]
	2,6-Difluoro-N-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide	IC50	11.0 [1], 54.0 [2]
	2-[3-Pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol	IC50	17.0 [1], 23.0 [2], 180.0 [3]
	4-[4-(1,4-Dihydroindeno[1,2-c]pyrazol-6-yl)-3-pyridin-4-ylpyrazol-1-yl]cyclohexan-1-amine	IC50	0.66 [1], 22.9 [2], 396.0 [3], 1516.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]benzenesulfonamide	IC50	7.0 [1], 17.0 [2], 20.0 [3], 28.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-methylpyrazole-4-sulfonamide	IC50	8.0 [1], 19.0 [2], 120.0 [3], 710.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]propane-2-sulfonamide	IC50	14.0 [1], 17.0 [2], 45.0 [3], 66.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]thiophene-2-sulfonamide	IC50	0.5 [1], 1.0 [2], 7.0 [3], 12.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]propane-1-sulfonamide	IC50	9.0 [1], 12.0 [2], 23.0 [3], 24.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclohexanesulfonamide	IC50	18.0 [1], 40.0 [2], 51.0 [3], 206.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopropanesulfonamide	IC50	41.0 [1], 50.0 [2], 132.0 [3], 173.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]morpholine-4-sulfonamide	IC50	62.0 [1], 102.0 [2], 293.0 [3], 1300.0 [4]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-3-sulfonamide	IC50	1.0 [1], 4.0 [2], 10.0 [3]
	1-(3-Chloro-4-fluorophenyl)-3-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]phenyl]urea	IC50	13.0 [1], 22.0 [2]
	5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone	IC50	1.5 [1], 5.4 [2], 10.71 [3]
	Acetamide, N-[3-[6-[(3,4,5-trimethoxyphenyl)amino]pyrazinyl]phenyl]-	IC50	3500.0 [1], 3600.0 [2]
	4-[2-(3-Tert-butylanilino)-1-methylbenzimidazol-5-yl]oxy-N-methylpyridine-2-carboxamide	IC50	45.0 [1], 280.0 [2]
	Pyrazolo[1,5-a]pyrimidine-3-carboxylate	IC50	1500.0 [1], 1540.0 [2]
	(1E)-5-(1-Piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	IC50	0.03 [1], 9.0 [2]
	N-[3-[2-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamide	IC50	2.0 [1], 4.0 [2], 97.0 [3]
	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea	IC50	23.0 [1], 2390.0 [2]
	3-(2-Aminopropan-2-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide	IC50	2.1 [1], 4.2 [2]
	(E)-Ethyl 3-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-ylamino)furo[2,3-c]pyridine-2-carboxylate	IC50	2.0 [1], 30.0 [2]
	2,6-Difluoro-N-[2-fluoro-3-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide	IC50	0.5 [1], 3.8 [2], 23.0 [3]
	N-[4-[2-(3-Tert-butylanilino)-1-methylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide	IC50	3.0 [1], 44.0 [2]
	4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamide	IC50	330.0 [1], 570.0 [2], 5000.0 [3]
	N-[3-(3-Aminoisoquinolin-7-yl)-2,4-difluorophenyl]propane-1-sulfonamide	IC50	8.7 [1], 549.0 [2], 549.54 [3]
	N-[4-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-3,5-difluorophenyl]propane-1-sulfonamide	IC50	13.0 [1], 160.0 [2], 800.0 [3]
	6-[2-[[3-(Dimethylsulfamoylamino)-2,6-Bis(Fluoranyl)phenyl]amino]pyridin-3-Yl]-7~{h}-Purine	IC50	8.0 [1], 54.0 [2], 90.0 [3]
	1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]urea	IC50	1.0 [1], 6.8 [2], 18.0 [3]
	1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]urea	IC50	4.2 [1], 11.0 [2], 40.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1,3-thiazole-2-sulfonamide	IC50	1.0 [1], 2.0 [2], 31.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1H-pyrazole-4-sulfonamide	IC50	0.2 [1], 1.0 [2], 6.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-2-sulfonamide	IC50	21.0 [1], 41.0 [2], 177.0 [3]
	6-[2-[3-(Diethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine	IC50	57.0 [1], 165.0 [2], 603.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyrrolidine-1-sulfonamide	IC50	2.0 [1], 31.0 [2], 44.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperidine-1-sulfonamide	IC50	15.0 [1], 38.0 [2], 65.0 [3]
	(3S)-N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamide	IC50	9.0 [1], 122.0 [2], 201.0 [3]
	(3R)-N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamide	IC50	16.0 [1], 68.0 [2], 233.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-methylpropane-1-sulfonamide	IC50	6.0 [1], 16.0 [2], 17.0 [3]
	1-Cyclopropyl-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide	IC50	8.0 [1], 26.0 [2], 33.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2-dimethylpropane-1-sulfonamide	IC50	5.0 [1], 6.0 [2], 63.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-fluorobenzenesulfonamide	IC50	3.0 [1], 10.0 [2], 12.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-fluorobenzenesulfonamide	IC50	3.0 [1], 4.0 [2], 15.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopentanesulfonamide	IC50	2.0 [1], 11.0 [2], 21.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxolane-3-sulfonamide	IC50	5.0 [1], 26.0 [2], 31.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxane-4-sulfonamide	IC50	31.0 [1], 179.0 [2], 356.0 [3]
	6-[2-[3-[[Ethyl(methyl)sulfamoyl]amino]-2,6-difluoroanilino]pyridin-3-yl]-7H-purine	IC50	22.0 [1], 87.0 [2], 157.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperazine-1-sulfonamide	IC50	1000.0 [1]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-phenylmethanesulfonamide	IC50	111.0 [1], 186.0 [2], 1000.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]butane-2-sulfonamide	IC50	7.0 [1], 27.0 [2], 38.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pentane-2-sulfonamide	IC50	18.0 [1], 112.0 [2], 130.0 [3]
	N-[2,4-Difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclobutanesulfonamide	IC50	4.0 [1], 41.0 [2], 46.0 [3]
	1-Propan-2-yl-3-[2-[3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amine	IC50	14.0 [1], 65.0 [2], 10000.0 [3]
	N-[3-Chloro-4-(trifluoromethyl)phenyl]-4-methyl-3-[[1-[2-[2-(4-methylpiperazin-1-yl)ethylamino]pyrimidin-4-yl]cyclopropanecarbonyl]amino]benzamide	IC50	12.6 [1], 19.7 [2]
	N-[(1R)-1-[4-[(6-Pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]acetamide	IC50	19.0 [1], 34.0 [2], 57.54 [3]
	N-Methyl-N-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]acetamide	IC50	57.0 [1], 57.54 [2], 63.0 [3]
	3-Methoxy-N-[(1R)-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]propanamide	IC50	26.92 [1], 27.0 [2], 60.0 [3]
	3-Methoxy-N-methyl-N-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]propanamide	IC50	32.0 [1], 32.36 [2], 45.0 [3]
	3-Methoxy-N-[(1S)-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]propanamide	IC50	51.0 [1], 51.29 [2], 160.0 [3]
	2-Chloro-3-(2-cyanopropan-2-yloxy)-N-[5-[[2-(cyclopropanecarbonylamino)-[1,3]thiazolo[5,4-b]pyridin-5-yl]-methylamino]-2-fluorophenyl]benzamide	IC50	38.0 [1], 47.0 [2], 69.0 [3]
	(5-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone	IC50	17.0 [1], 24.2 [2], 1500.0 [3]
	N-(6-Amino-5-Bromopyridin-3-Yl)-2,6-Difluoro-3-[(Propylsulfonyl)amino]benzamide	IC50	110.0 [1], 310.0 [2], 1200.0 [3]
	N-[3-(Dimethylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide	IC50	8.2 [1], 40.0 [2], 650.0 [3]
	1-(5-Tert-butyl-2-phenylpyrazol-3-yl)-3-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]urea	IC50	89.0 [1], 1330.0 [2], 3140.0 [3]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-b-raf-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase B-raf Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-b-raf-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan