Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	7-[(1S)-1-(4-Fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	61.0 [1], 62.0 [2]
	7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	82.0 [1], 117.0 [2]
	7-[(2R)-Butan-2-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	738.0 [1]
	7-(1-Acetylpiperidin-4-yl)-2-anilino-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	1300.0 [1], 1302.0 [2]
	7-Cyclohexyl-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	346.0 [1]
	Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-	IC50	10000.0 [1]
	JNK Inhibitor VIII	Ki	6700.0 [1]
	N-[3-[[5-Cyclopropyl-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide	IC50	12.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	6700.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	6700.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	6667.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	6700.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	6700.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	6700.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	6700.0 [1]
	7-Chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione	Ki	6670.0 [1]
	5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	IC50	210.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	1.2 [1]
	Tilfrinib	IC50	10000.0 [1]
	3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea	IC50	10000.0 [1]
	3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea	IC50	1508.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	5000.0 [1]
	7-(1-Acetylpiperidin-4-yl)-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	2100.0 [1]
	5,5,7-Trimethyl-2-(3-piperazin-1-ylanilino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	850.0 [1]
	2-Anilino-7-[(1R)-2,2-difluoro-1-phenylethyl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	2564.0 [1]
	2-Anilino-5,5-dimethyl-7-phenylpyrrolo[2,3-d]pyrimidin-6-one	IC50	2800.0 [1]
	2-Anilino-7-cyclopentyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	226.0 [1]
	2-Anilino-7-cyclohexyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	304.0 [1]
	7'-[(2S)-Butan-2-yl]-2'-(pyridin-3-ylamino)spiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-6'-one	IC50	60.0 [1]
	7-Cyclohexyl-5,5-dimethyl-N-phenyl-6H-pyrrolo[2,3-d]pyrimidin-2-amine	IC50	30000.0 [1]
	7-[(1S)-1-(3-Hydroxyphenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	10.0 [1]
	7-[(1R)-1-(4-Fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	1524.0 [1]
	7-[(1S)-4-Amino-2,3-dihydro-1H-inden-1-yl]-2-anilino-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	10.0 [1]
	2-Anilino-5,5-dimethyl-7-[(2S)-3-methylbutan-2-yl]pyrrolo[2,3-d]pyrimidin-6-one	IC50	80.0 [1]
	7-(1-Acetylpiperidin-4-yl)-2-(4-fluoroanilino)-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	2800.0 [1]
	2-Anilino-5,5-dimethyl-7-propan-2-ylpyrrolo[2,3-d]pyrimidin-6-one	IC50	627.0 [1]
	2-Anilino-7-ethyl-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	3000.0 [1]
	2-Anilino-5,5-dimethyl-6-(1-methylpyrazol-4-yl)pyrrolo[3,4-d]pyrimidin-7-one	IC50	30000.0 [1]
	7-Cyclohexyl-5,5-dimethyl-2-(3-piperazin-1-ylanilino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	14.0 [1]
	7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-[4-(5-methyl-1H-1,2,4-triazol-3-yl)anilino]pyrrolo[2,3-d]pyrimidin-6-one	IC50	80.0 [1]
	5,5-Dimethyl-7-(2-phenylpropan-2-yl)-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	1644.0 [1]
	7-[(2S)-Butan-2-yl]-5,5-dimethyl-2-(4-methylsulfonylanilino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	120.0 [1]
	2-Anilino-5,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-6-one	IC50	12770.0 [1]
	2-Anilino-5,5-dimethyl-7-(1-methylpyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-6-one	IC50	4300.0 [1]
	7-[(1S)-2,3-Dihydro-1H-inden-1-yl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	27.0 [1]
	7-[(1R)-1-(3-Hydroxyphenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	1800.0 [1]
	N-[(1S)-1-(2-Anilino-5,5-dimethyl-6-oxopyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydro-1H-inden-4-yl]methanesulfonamide	IC50	19.0 [1]
	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide	IC50	3650.0 [1]
	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	IC50	10000.0 [1]
	N-[3-[[5-Cyclopropyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide	IC50	20.0 [1]
	5,5-Dimethyl-7-[(1S)-1-phenylethyl]-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one	IC50	37.0 [1]
	3-(Tert-butylamino)-4-[[2-(4-pyridin-4-ylanilino)pyrimidin-4-yl]amino]cyclobut-3-ene-1,2-dione	Ki	4830.0 [1]
	N-[(6S)-6-Amino-2,2-difluorocyclohexyl]-5-chloro-4-imidazo[1,2-a]pyridin-3-yl-1,3-thiazole-2-carboxamide	IC50	720.0 [1]
	N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-4-imidazo[1,2-b]pyridazin-3-yl-5-methylthiophene-2-carboxamide	IC50	20.0 [1]
	N-[(6S)-6-Amino-2,2-difluorocyclohexyl]-4-imidazo[1,2-b]pyridazin-3-ylthiophene-2-carboxamide	IC50	15.0 [1]
	N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-5-ethyl-4-(7-methylimidazo[1,2-b]pyridazin-3-yl)thiophene-2-carboxamide	IC50	140.0 [1]
	N-[(6R)-6-Amino-2,2-difluorocyclohexyl]-4-[7-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]thiophene-2-carboxamide	IC50	0.5 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 60 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-c-tak1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase c-TAK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-c-tak1-inhibitors-ic50-ki.
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