Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	1.2 [1]
	Isogranulatimide	IC50	100.0 [1]
	Debromohymenialdisine	IC50	330.0 [1], 725.0 [2], 3000.0 [3]
	Granulatimide	IC50	80.0 [1], 81.0 [2], 250.0 [3]
	(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide	IC50	5.0 [1], 6.0 [2], 7.89 [3]
	4-[4-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl]phenol	IC50	1.6 [1], 2.0 [2]
	4-[4-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl]phenol	Ki	1.58 [1]
	2-(Carbamoylamino)-5-Phenyl-N-[(3s)-Piperidin-3-Yl]thiophene-3-Carboxamide	IC50	7.0 [1]
	4-(6-{[(4-Methylcyclohexyl)amino]methyl}-1,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)benzoic Acid	IC50	20.0 [1], 22.0 [2]
	4-(6-{[(4-Methylcyclohexyl)amino]methyl}-1,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)benzoic Acid	Ki	19.95 [1]
	9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dione	IC50	47.0 [1]
	(R)-5-(8-Chloroisoquinolin-3-Ylamino)-3-(1-(Dimethylamino)propan-2-Yloxy)pyrazine-2-Carbonitrile	IC50	6.1 [1], 13.0 [2], 55.0 [3]
	Hymenialdisine Analogue 1	IC50	234.0 [1], 237.0 [2], 470.0 [3]
	CID 54758482	IC50	6.0 [1], 7.7 [2], 29.0 [3]
	Bis-imide A	IC50	20.0 [1]
	(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one	IC50	7.0 [1]
	(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one	Ki	31.62 [1]
	7-Chloro-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile	IC50	7.0 [1], 11.0 [2]
	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	IC50	6.2 [1]
	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Ki	6.31 [1]
	7-Chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,17(21),18-hexaene-18-carbonitrile	IC50	6.0 [1]
	9-(3-Methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	IC50	10.0 [1]
	9-(3-Methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	Ki	10.0 [1]
	Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinate	IC50	21.0 [1], 36.0 [2], 825.0 [3]
	3-[4-(4-Methylpiperazin-1-Yl)phenyl]-9h-Pyrrolo[2,3-B:5,4-C']dipyridine-6-Carbonitrile	IC50	1.3 [1], 98.0 [2]
	3-[(2R)-1-(Dimethylamino)propan-2-yl]oxy-5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrile	IC50	3.1 [1], 8.0 [2], 27.0 [3]
	(2S,3R,4R,6R,18S)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	5.6 [1], 10.0 [2]
	Hymenialdisine	IC50	1900.0 [1], 1950.0 [2]
	Wee1 Inhibitor	IC50	440.0 [1]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	IC50	4200.0 [1]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	Ki	5011.87 [1]
	4-(2,6-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	1200.0 [1]
	2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanol	IC50	20900.0 [1]
	2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanol	Ki	13700.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	220.0 [1]
	Wee1 Inhibitor II	IC50	35000.0 [1]
	9-Hydroxy-6-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	56.0 [1]
	1-(5-Chloro-2,4-Dimethoxyphenyl)-3-(5-Cyanopyrazin-2-Yl)urea	IC50	7.0 [1]
	1-(5-Chloro-2,4-Dimethoxyphenyl)-3-(5-Cyanopyrazin-2-Yl)urea	Ki	10.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	170.0 [1]
	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	IC50	16000.0 [1]
	9-(4-Hydroxy-3-methoxyphenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	IC50	82.0 [1]
	9-(4-Hydroxy-3-methoxyphenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	Ki	79.43 [1]
	4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid	IC50	7.9 [1]
	4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid	Ki	7.94 [1]
	3-[5-Chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea	IC50	3.0 [1]
	3-[5-Chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea	Ki	3.16 [1]
	7-Chloro-3-oxo-8-(pyridin-4-ylmethylamino)-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrile	IC50	13.0 [1]
	7-Chloro-3-oxo-8-(pyridin-4-ylmethylamino)-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrile	Ki	12.59 [1]
	18-Chloro-11,12,13,14-Tetrahydro-1h,10h-8,4-(Azeno)-9,15,1,3,6-Benzodioxatriazacycloheptadecin-2-One	IC50	10.0 [1]
	18-Chloro-11,12,13,14-Tetrahydro-1h,10h-8,4-(Azeno)-9,15,1,3,6-Benzodioxatriazacycloheptadecin-2-One	Ki	7.94 [1]
	(S)-2-Phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]pyridine-7-carboxamide	IC50	4.0 [1], 7.0 [2]
	4,9,19-Triazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaene-3,5,10-trione	IC50	50.0 [1], 51.0 [2]
	3-(4'-Hydroxybiphenyl-4-Yl)-2,4-Dihydroindeno[1,2-C]pyrazol-6-Ol	IC50	4.4 [1]
	3-(4'-Hydroxybiphenyl-4-Yl)-2,4-Dihydroindeno[1,2-C]pyrazol-6-Ol	Ki	6.31 [1]
	4-[4-[6-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenol	IC50	7.7 [1]
	4-[4-[6-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenol	Ki	7.94 [1]
	3-[5-(Morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carbonitrile	IC50	30.0 [1]
	8-Hydroxy-6,9,19-triazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(19),2,4,7,11,13,15,17-octaen-10-one	IC50	24.0 [1]
	4'-[7-(Hydroxymethyl)-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl]biphenyl-4-Ol	IC50	4.4 [1]
	4'-[7-(Hydroxymethyl)-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl]biphenyl-4-Ol	Ki	3.98 [1]
	4-(6-(((1r,4r)-4-Methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol	IC50	124.0 [1]
	4-(6-(((1r,4r)-4-Methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol	Ki	125.89 [1]
	4-[4-[5-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenol	IC50	7.8 [1]
	4-[4-[5-(Hydroxymethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]phenyl]phenol	Ki	7.94 [1]
	4-(5-(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridin-2-yl)phenol	IC50	0.5 [1]
	4-(5-(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridin-2-yl)phenol	Ki	0.25 [1]
	2-[[3-[4-(4-Hydroxyphenyl)phenyl]-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]oxy]propane-1,3-diol	IC50	0.1 [1]
	2-[[3-[4-(4-Hydroxyphenyl)phenyl]-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]oxy]propane-1,3-diol	Ki	0.1 [1]
	N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyrimidin-5-ylpyridin-3-yl)-1,3-thiazol-2-amine	IC50	37.0 [1]
	N-(4-Piperazin-1-ylpyridin-2-yl)-5-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-amine	IC50	8.0 [1]
	5-[2-[[4-(4-Acetylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-N-(2-aminoethyl)pyridine-3-carboxamide	IC50	0.03 [1]
	N-(2-Aminoethyl)-5-[2-[[4-(4-methylsulfonylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide	IC50	0.03 [1]
	N-(2-Aminoethyl)-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide	IC50	0.05 [1]
	3-Methyl-N-[3-(1-methylpyrazol-4-yl)-5-piperidin-3-ylpyrazolo[1,5-a]pyrimidin-7-yl]-1,2-thiazol-5-amine	IC50	9.0 [1]
	5-(6-Methylpyridin-3-yl)-N-(4-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amine	IC50	37.0 [1]
	7-Chloro-3-oxo-11,18-dioxa-2,4,21,23-tetrazatricyclo[17.3.1.05,10]tricosa-1(22),5(10),6,8,19(23),20-hexaene-20-carbonitrile	IC50	28.0 [1]
	4,14-Diazapentacyclo[11.7.0.02,6.07,12.015,20]icosa-1,6,9,12,15,17,19-heptaene-3,5,8,11-tetrone	IC50	269.0 [1]
	8,11-Dihydroxy-4,14-diazapentacyclo[11.7.0.02,6.07,12.015,20]icosa-1(13),2(6),7,9,11,15,17,19-octaene-3,5-dione	IC50	311.0 [1]
	1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea	IC50	5.0 [1]
	1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea	Ki	3.98 [1]
	2-(2,3-Dihydro-1-Benzofuran-5-Yl)-N-[2-(Piperazin-1-Yl)phenyl]-1,3-Thiazole-4-Carboxamide	IC50	75.0 [1]
	8-Chloro-5,10-Dihydro-11h-Dibenzo[b,E][1,4]diazepin-11-One	IC50	17000.0 [1]
	8-Chloro-5,10-Dihydro-11h-Dibenzo[b,E][1,4]diazepin-11-One	Ki	15848.93 [1]
	Ethyl 4-[2-(aminomethyl)morpholin-4-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate	IC50	1000.0 [1], 1200.0 [2]
	5-(6,7-Dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)pyridine-2-carbonitrile	IC50	0.8 [1], 0.81 [2]
	6,7-Dimethoxy-3-[4-(1h-Tetrazol-5-Yl)phenyl]-1,4-Dihydroindeno[1,2-C]pyrazole	IC50	11.0 [1]
	6,7-Dimethoxy-3-[4-(1h-Tetrazol-5-Yl)phenyl]-1,4-Dihydroindeno[1,2-C]pyrazole	Ki	12.59 [1]
	4-[(6,7-Dimethoxy-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)ethynyl]-2-Methoxyphenol	IC50	5.0 [1]
	4-[(6,7-Dimethoxy-2,4-Dihydroindeno[1,2-C]pyrazol-3-Yl)ethynyl]-2-Methoxyphenol	Ki	5.01 [1]
	(13Z)-8-Amino-7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,13,17(21),18-heptaene-18-carbonitrile	IC50	0.3 [1]
	(13Z)-8-Amino-7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5(10),6,8,13,17(21),18-heptaene-18-carbonitrile	Ki	0.32 [1]
	5-Methyl-8-(1h-Pyrrol-2-Yl)[1,2,4]triazolo[4,3-A]quinolin-1(2h)-One	IC50	0.1 [1]
	8-[4-(Hydroxymethyl)phenyl]-5-methyl-2H-[1,2,4]triazolo[4,3-a]quinolin-1-one	IC50	10.0 [1]
	5-Methyl-8-(thiophen-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one	IC50	20.0 [1]
	3-(1-Methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine	IC50	60.0 [1]
	3-Bromo-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine	IC50	1080.0 [1]
	1-Morpholin-4-yl-2-[4-[2-[(5-pyridin-3-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl]piperazin-1-yl]ethanone	IC50	47.0 [1]
	N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyridin-3-ylpyridin-3-yl)-1,3-thiazol-2-amine	IC50	19.0 [1]
	5-Methyl[1,2,4]triazolo[4,3-a]quinolin-1(2h)-one	IC50	800.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase Chk1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-chk1-inhibitors-ic50-ki.
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