Serine/threonine-protein kinase/endoribonuclease IRE1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3,5-Dibromosalicylaldehyde	IC50	720.0 [1], 20000.0 [2]
	CID 25160990	IC50	5665.0 [1], 20000.0 [2]
	2-Hydroxy-3-methoxybenzaldehyde	IC50	5750.0 [1]
	5-Bromosalicylaldehyde	IC50	1330.0 [1]
	2,3-Dihydroxybenzaldehyde	IC50	20250.0 [1]
	5-Chlorosalicylaldehyde	IC50	3120.0 [1]
	2-Hydroxy-5-nitrobenzaldehyde	IC50	1280.0 [1]
	3,5-Dichlorosalicylaldehyde	IC50	1750.0 [1]
	2-Hydroxy-5-methoxybenzaldehyde	IC50	8850.0 [1]
	3-Bromo-5-chloro-2-hydroxybenzaldehyde	IC50	1300.0 [1]
	3,5-Diiodosalicylaldehyde	IC50	440.0 [1]
	5-Bromo-2-hydroxy-3-methoxybenzaldehyde	IC50	240.0 [1]
	4,6-Dimethoxysalicylaldehyde	IC50	6830.0 [1]
	5-Chloro-2-hydroxyisophthalaldehyde	IC50	400.0 [1]
	2-Hydroxy-3-methoxy-5-nitrobenzaldehyde	IC50	170.0 [1]
	2-Hydroxy-5-iodobenzaldehyde	IC50	1400.0 [1]
	6-Bromo-2-hydroxy-3-methoxybenzaldehyde	IC50	80.0 [1]
	3-Fluorosalicylaldehyde	IC50	2850.0 [1]
	3-Nitrosalicylaldehyde	IC50	5500.0 [1]
	4-N-[4-[2-[4-(1H-Benzimidazol-2-ylamino)naphthalen-1-yl]oxypyridin-3-yl]pyrimidin-2-yl]cyclohexane-1,4-diamine	IC50	11.0 [1], 43.0 [2]
	2-(2-Hydroxyethyliminomethyl)-4-bromo-6-methoxyphenol	IC50	154.0 [1]
	CID 59599728	IC50	5.0 [1]
	3-Hydroxy-4-methoxynaphthalene-2-carbaldehyde	IC50	2260.0 [1]
	2-Hydroxy-5-(pyridin-3-yl)benzaldehyde	IC50	141.0 [1]
	2-Hydroxy-5-(pyridin-4-yl)benzaldehyde	IC50	147.0 [1]
	6-Hydroxyquinoline-5-carbaldehyde	IC50	170.0 [1]
	7-Hydroxyquinoline-8-carbaldehyde	IC50	1240.0 [1]
	2-Methoxy-6-[(4-methoxyphenyl)methyliminomethyl]-4-thiophen-2-ylphenol	IC50	23.0 [1]
	2-(2-Hydroxyethyliminomethyl)-6-methoxy-4-thiophen-2-ylphenol	IC50	15.0 [1]
	2-(Cyclopropyliminomethyl)-6-methoxy-4-thiophen-2-ylphenol	IC50	34.0 [1]
	2-Methoxy-6-[(E)-pyridin-2-yliminomethyl]-4-thiophen-2-ylphenol	IC50	20000.0 [1]
	6-(5-Formyl-6-hydroxynaphthalen-2-yl)pyridine-2-carboxylic acid	IC50	125.0 [1]
	6-(5-Formyl-6-hydroxynaphthalen-2-yl)-N-(2-morpholin-4-ylethyl)pyridine-2-carboxamide	IC50	48.0 [1]
	2-Hydroxy-6-[6-(morpholine-4-carbonyl)pyridin-2-yl]naphthalene-1-carbaldehyde	IC50	645.0 [1]
	2-Hydroxy-3-nitro-5-quinolin-5-ylbenzaldehyde	IC50	333.0 [1], 3333.0 [2]
	2-Hydroxy-3-methoxy-5-pyridin-4-ylbenzaldehyde	IC50	104.0 [1]
	4-Bromo-2-hydroxy-3-[(4-methoxyphenyl)methyliminomethyl]benzoic acid	IC50	20000.0 [1]
	4-Bromo-3-(cyclopropyliminomethyl)-2-hydroxybenzoic acid	IC50	9523.0 [1]
	2-Hydroxy-3-methoxy-5-pyridin-2-ylbenzaldehyde	IC50	108.0 [1]
	2-[2-[2-[(2-Hydroxy-3-methoxy-5-thiophen-2-ylphenyl)methylideneamino]ethyldisulfanyl]ethyliminomethyl]-6-methoxy-4-thiophen-2-ylphenol	IC50	1348.0 [1]
	2-Hydroxy-6-quinolin-5-ylnaphthalene-1-carbaldehyde	IC50	6277.0 [1]
	6-(5-Formyl-6-hydroxynaphthalen-2-yl)-N-propan-2-ylpyridine-2-carboxamide	IC50	47.0 [1]
	6-Hydroxy-N-[(4-methoxyphenyl)methyl]-5-[(4-methoxyphenyl)methyliminomethyl]naphthalene-2-carboxamide	IC50	20000.0 [1]
	3-Fluoro-2-hydroxy-5-quinolin-5-ylbenzaldehyde	IC50	305.0 [1]
	4-Bromo-2-[2-[2-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylideneamino]ethyldisulfanyl]ethyliminomethyl]-6-methoxyphenol	IC50	2117.0 [1]
	6-Hydroxy-N-[(4-methoxyphenyl)methyl]-5-[(4-methoxyphenyl)methyliminomethyl]naphthalene-1-carboxamide	IC50	20000.0 [1]
	2-Hydroxy-3-methoxy-5-quinolin-5-ylbenzaldehyde	IC50	932.0 [1]
	5-Isoquinolinecarboxaldehyde, 6-hydroxy-	IC50	427.0 [1]
	4-Bromo-2-methoxy-6-[(4-methoxyphenyl)methyliminomethyl]phenol	IC50	221.0 [1]
	2-Hydroxy-6-[6-(4-methylpiperazine-1-carbonyl)pyridin-2-yl]naphthalene-1-carbaldehyde	IC50	389.0 [1]
	4-Bromo-2-methoxy-6-[(E)-1,3-thiazol-2-yliminomethyl]phenol	IC50	641.0 [1]
	4-Bromo-2-(cyclopropyliminomethyl)-6-methoxyphenol	IC50	110.0 [1]
	2-Hydroxy-3-methoxy-5-thien-2-ylbenzaldehyde	IC50	22.0 [1]
	3'-Formyl-4'-hydroxy[1,1'-biphenyl]-4-carboxylic acid	IC50	172.0 [1]
	3'-Formyl-4'-hydroxy[1,1'-biphenyl]-3-carboxylic acid	IC50	371.0 [1]
	Methyl 3'-formyl-4'-hydroxy[1,1'-biphenyl]-4-carboxylate	IC50	351.0 [1]
	Methyl 3'-formyl-4'-hydroxy[1,1'-biphenyl]-3-carboxylate	IC50	421.0 [1]
	2-Hydroxy-5-(3-thienyl)benzaldehyde	IC50	699.0 [1]
	5-(Furan-2-yl)-2-hydroxybenzaldehyde	IC50	223.0 [1]
	2-Hydroxy-5-(5-pyrimidinyl)benzaldehyde	IC50	170.0 [1]
	3'-Formyl-4'-hydroxy-5'-methoxybiphenyl-3-carboxylic acid	IC50	102.0 [1]
	N-Cyclohexyl-3-(3-formyl-4-hydroxy-5-methoxyphenyl)benzamide	IC50	19.0 [1]
	6-Bromo-2-hydroxy-3-(morpholine-4-carbonyl)benzaldehyde	IC50	526.0 [1]
	5-(1,3-Dimethyl-2,4-dioxopyrimidin-5-yl)-2-hydroxy-3-methoxybenzaldehyde	IC50	1581.0 [1]
	2-Hydroxy-6-pyridin-3-ylnaphthalene-1-carbaldehyde	IC50	23.0 [1]
	2-Hydroxy-6-[3-(morpholine-4-carbonyl)phenyl]naphthalene-1-carbaldehyde	IC50	74.0 [1]
	3-Hydroxy-2-methylquinoline-4-carbaldehyde	IC50	36370.0 [1]
	Ethyl 2-(5-bromo-2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-5-carboxylate	IC50	17662.0 [1]
	4-Bromo-2-methoxy-6-(1,3-thiazolidin-2-yl)phenol	IC50	4146.0 [1]
	4-Bromo-2-hydroxy-3-(1,3-thiazolidin-2-yl)benzoic acid	IC50	20000.0 [1]
	2-Methoxy-6-(1,3-thiazolidin-2-yl)-4-thiophen-2-ylphenol	IC50	20000.0 [1]
	3,5-Difluoro-2-hydroxybenzaldehyde	IC50	3060.0 [1]
	1-[(2-Mercaptoethyl)iminomethyl]-2-naphthol	IC50	20000.0 [1]
	2-Hydroxy-3-methoxy-5-thiophen-3-ylbenzaldehyde	IC50	199.0 [1]
	5-(2-Fluorophenyl)-2-hydroxy-3-methoxybenzaldehyde	IC50	400.0 [1]
	2-Hydroxy-3-methoxy-5-(4-methoxyphenyl)benzaldehyde	IC50	1380.0 [1]
	2-Hydroxy-3-methoxy-5-(3-methoxyphenyl)benzaldehyde	IC50	400.0 [1]
	2-Hydroxy-3-methoxy-5-(2-methoxyphenyl)benzaldehyde	IC50	1590.0 [1]
	5-(2-Chlorophenyl)-2-hydroxy-3-methoxybenzaldehyde	IC50	1280.0 [1]
	5-(4-Chlorophenyl)-2-hydroxy-3-methoxybenzaldehyde	IC50	1830.0 [1]
	5-(3,4-Dimethoxyphenyl)-2-hydroxy-3-methoxybenzaldehyde	IC50	380.0 [1]
	5-(5-Chloro-2-methoxyphenyl)-2-hydroxy-3-methoxybenzaldehyde	IC50	1640.0 [1]
	2-Hydroxy-3-methoxy-5-(1H-pyrazol-4-yl)benzaldehyde	IC50	310.0 [1]
	2-Hydroxy-3-methoxy-5-pyridin-3-ylbenzaldehyde	IC50	149.0 [1]
	2-Hydroxy-3-methoxy-5-pyrimidin-5-ylbenzaldehyde	IC50	39.0 [1]
	2-Hydroxy-3-methoxy-5-(1-methylpyrazol-4-yl)benzaldehyde	IC50	772.0 [1]
	3-(3-Formyl-4-hydroxy-5-methoxyphenyl)benzamide	IC50	173.0 [1]
	N-Benzyl-3-(3-formyl-4-hydroxyphenyl)benzamide	IC50	106.0 [1]
	N-Benzyl-3-(3-formyl-4-hydroxy-5-methoxyphenyl)benzamide	IC50	6.0 [1]
	3-(3-Fluoro-5-formyl-4-hydroxyphenyl)benzamide	IC50	46.0 [1]
	2,3-Dibromo-6-hydroxy-5-methoxybenzaldehyde	IC50	30.0 [1]
	5-Chloro-2-hydroxy-3-methoxybenzaldehyde	IC50	280.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-hydroxybenzaldehyde	IC50	1011.0 [1]
	3'-Formyl-4'-hydroxy[1,1'-biphenyl]-3-carboxamide	IC50	197.0 [1]
	4-[Benzo(B)thiophen-2-YL]-2-formylphenol	IC50	20000.0 [1]
	3'-Formyl-4'-hydroxy-N,N-dimethyl[1,1'-biphenyl]-3-carboxamide	IC50	147.0 [1]
	4-[4-(N,N-Dimethylaminocarbonyl)phenyl]-2-formylphenol	IC50	420.0 [1]
	4-(3-Formyl-4-hydroxy-5-nitrophenyl)benzoic acid	IC50	101.0 [1]
	3-(3-Formyl-4-hydroxy-5-nitrophenyl)benzoic acid	IC50	132.0 [1]
	Methyl 4-(3-formyl-4-hydroxy-5-nitrophenyl)benzoate	IC50	21.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase/endoribonuclease IRE1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-endoribonuclease-ire1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase/endoribonuclease IRE1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-endoribonuclease-ire1-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan