Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Dactolisib	IC50	20.74 [1]
	PI-103	IC50	19.0 [1]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	3018.0 [1]
	Pictilisib	IC50	410.0 [1]
	Pictilisib	Ki	570.0 [1], 580.0 [2]
	Sirolimus	IC50	3.47 [1]
	4-[5-(4-Hydroxyphenyl)-2-oxo-1H-imidazo[4,5-b]pyrazin-3-yl]cyclohexane-1-carboxamide	IC50	5000.0 [1]
	[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol	IC50	0.13 [1], 0.8 [2], 4.0 [3], 8.0 [4], 13.0 [5]
	PF-04691502	IC50	7.9 [1]
	PF-04691502	Ki	16.0 [1]
	CID 46244454	IC50	38.0 [1], 720.0 [2], 2400.0 [3]
	Buparlisib	IC50	94.0 [1], 1981.0 [2], 4600.0 [3]
	Buparlisib	Ki	199.0 [1]
	Ku-0063794	IC50	2.5 [1], 3.0 [2], 100.0 [3], 150.0 [4]
	Omipalisib	IC50	0.18 [1], 0.3 [2], 0.31 [3], 0.68 [4]
	(3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol	IC50	634.0 [1], 691.0 [2], 1000.0 [3]
	1-(4-Amino-6-Methyl-1,3,5-Triazin-2-Yl)-N-(1h-Pyrazol-3-Yl)-1h-Benzimidazol-2-Amine	IC50	23.0 [1], 27.0 [2], 55.0 [3], 390.0 [4]
	2-[[4-[2-(3-Hydroxyanilino)benzimidazol-1-yl]-6-methyl-1,3,5-triazin-2-yl]amino]acetonitrile	IC50	8.0 [1], 17.0 [2], 380.0 [3]
	[(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrile	IC50	93.0 [1], 97.0 [2], 700.0 [3], 1700.0 [4]
	2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol	IC50	8.0 [1]
	2-(Morpholin-4-yl)-benzo[h]chromen-4-one	IC50	6400.0 [1]
	4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine	IC50	350.0 [1], 370.0 [2]
	Vistusertib	IC50	2.8 [1], 20.0 [2]
	Apitolisib	Ki	17.0 [1]
	Gedatolisib	IC50	0.4 [1], 1.6 [2]
	Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane	IC50	370.0 [1], 5700.0 [2], 23000.0 [3]
	1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea	IC50	1.7 [1], 2.0 [2], 3.0 [3]
	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	10.0 [1]
	4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	IC50	4763.0 [1], 4800.0 [2], 10000.0 [3]
	CID 118502708	IC50	200.0 [1], 610.0 [2]
	4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	IC50	10000.0 [1], 14800.0 [2]
	4-Hydroxy-3,5-dimethoxybenzaldehyde [4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone	IC50	270.0 [1], 1370.0 [2]
	Bimiralisib	IC50	89.0 [1], 205.0 [2]
	Bimiralisib	Ki	62.0 [1]
	1-Methyl-3-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]urea	IC50	0.38 [1], 0.4 [2]
	Methyl 4-[6-[4-(methylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate	IC50	0.46 [1], 0.5 [2]
	5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine	IC50	29.0 [1]
	5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine	Ki	29.0 [1]
	1-Ethyl-3-[4-[6-(2-hydroxypropan-2-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]phenyl]urea	Ki	3.0 [1]
	4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]-1H-indole	IC50	330.0 [1], 1460.0 [2], 5900.0 [3]
	2-Amino-8-cyclopentyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one	IC50	30.09 [1]
	2-Amino-8-cyclopentyl-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one	Ki	142.0 [1], 200.0 [2]
	1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]urea	IC50	6.0 [1], 48.0 [2]
	1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]urea	Ki	8.0 [1]
	(3R)-3-Methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine	IC50	34.0 [1], 270.0 [2], 1400.0 [3]
	N-Methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine	IC50	52.0 [1], 1500.0 [2], 4000.0 [3]
	3-(Oxan-4-ylmethyl)-5-[4-(1H-1,2,4-triazol-5-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one	IC50	2.0 [1], 150.0 [2], 273.0 [3]
	5-(1H-Indol-5-yl)-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one	IC50	21.0 [1], 50.0 [2], 231.0 [3]
	5-(3H-Benzimidazol-5-yl)-3-(cyclohexylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one	IC50	21.0 [1], 137.0 [2], 427.0 [3]
	5-[4-(1H-Imidazol-2-yl)phenyl]-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one	IC50	5.0 [1], 55.0 [2], 273.0 [3]
	5-[[1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]benzene-1,3-diol	IC50	0.2 [1], 5.0 [2], 97.0 [3]
	3-[[4-Methyl-6-[2-(1H-pyrazol-5-ylamino)benzimidazol-1-yl]-1,3,5-triazin-2-yl]amino]propanenitrile	IC50	60.0 [1], 82.0 [2], 1300.0 [3]
	N-[3-[[1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]phenyl]acetamide	IC50	120.0 [1], 290.0 [2], 1500.0 [3]
	3-(1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenol	IC50	7.0 [1], 9.0 [2], 150.0 [3]
	1-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-indazol-6-yl)benzimidazol-2-amine	IC50	27.0 [1], 120.0 [2], 1500.0 [3]
	3-(1-(2-Methylpyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenol	IC50	370.0 [1], 600.0 [2], 8900.0 [3]
	3-(1-(6-Amino-2-methylpyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenol	IC50	43.0 [1], 87.0 [2], 1200.0 [3]
	2-[[4-Methyl-6-[2-(1H-pyrazol-5-ylamino)benzimidazol-1-yl]-1,3,5-triazin-2-yl]amino]acetonitrile	IC50	31.0 [1], 73.0 [2], 600.0 [3]
	1-(2-Cyanoethyl)-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	IC50	26.0 [1], 30.0 [2]
	1-(2-Cyanoethyl)-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	Ki	3.2 [1]
	1-[(2R)-2,3-Dihydroxypropyl]-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	IC50	37.0 [1], 47.0 [2]
	1-[(2R)-2,3-Dihydroxypropyl]-3-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	Ki	3.6 [1]
	1-Ethyl-3-[4-[(7S)-7-(2-methoxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	IC50	12.0 [1], 15.0 [2]
	1-Ethyl-3-[4-[(7S)-7-(2-methoxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	Ki	1.7 [1]
	1-[4-[(7S)-7-(2-Cyanoethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	IC50	11.0 [1], 15.0 [2]
	1-[4-[(7S)-7-(2-Cyanoethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	Ki	1.3 [1]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	IC50	4.6 [1], 13.0 [2]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	Ki	1.4 [1]
	1-Ethyl-3-[4-[(7R)-7-(hydroxymethyl)-7-methyl-4-morpholin-4-yl-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	IC50	30.0 [1], 32.0 [2]
	1-Ethyl-3-[4-[(7R)-7-(hydroxymethyl)-7-methyl-4-morpholin-4-yl-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	Ki	4.4 [1]
	1-Ethyl-3-[4-[(7S)-7-(2-hydroxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	IC50	1.6 [1], 1.7 [2]
	1-Ethyl-3-[4-[(7S)-7-(2-hydroxyethyl)-7-methyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]urea	Ki	0.7 [1]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(oxetan-3-yl)urea	IC50	30.0 [1], 37.0 [2]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(oxetan-3-yl)urea	Ki	3.0 [1]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)urea	IC50	4.0 [1], 4.8 [2]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)urea	Ki	1.6 [1]
	1-Ethyl-3-[4-[1-methyl-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	IC50	8.0 [1], 47.0 [2]
	1-Ethyl-3-[4-[1-methyl-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	Ki	8.0 [1]
	1-Ethyl-3-[4-[7-methyl-6-[(3S)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea	IC50	630.0 [1], 2200.0 [2]
	1-Ethyl-3-[4-[7-methyl-6-[(3S)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea	Ki	30.0 [1]
	1-Ethyl-3-[4-[7-methyl-6-[(3R)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea	IC50	650.0 [1], 730.0 [2]
	1-Ethyl-3-[4-[7-methyl-6-[(3R)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea	Ki	69.0 [1]
	(S)-1-Ethyl-3-(4-(6-(3-ethylmorpholino)-7-methyl-7H-purin-2-yl)phenyl)urea	IC50	69.0 [1], 153.0 [2]
	(S)-1-Ethyl-3-(4-(6-(3-ethylmorpholino)-7-methyl-7H-purin-2-yl)phenyl)urea	Ki	4.0 [1]
	1-Ethyl-3-[4-[7-methyl-6-(1,4-oxazepan-4-yl)purin-2-yl]phenyl]urea	IC50	7200.0 [1], 8900.0 [2]
	1-Ethyl-3-[4-[7-methyl-6-(1,4-oxazepan-4-yl)purin-2-yl]phenyl]urea	Ki	120.0 [1]
	1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1,3-dimethylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	IC50	4.0 [1], 8.0 [2]
	1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1,3-dimethylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	Ki	2.0 [1]
	1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1-methylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	IC50	8.0 [1], 15.0 [2]
	1-Ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1-methylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	Ki	1.0 [1]
	1-Ethyl-3-[4-[1-methyl-7-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	IC50	270.0 [1], 340.0 [2]
	1-Ethyl-3-[4-[1-methyl-7-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea	Ki	28.0 [1]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5-oxofuro[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	IC50	7.6 [1], 13.0 [2]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5-oxofuro[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea	Ki	1.2 [1]
	1-[4-(7,7-Dimethyl-4-morpholin-4-yl-5-oxofuro[3,4-d]pyrimidin-2-yl)phenyl]-3-ethylurea	IC50	16.0 [1], 20.0 [2]
	1-[4-(7,7-Dimethyl-4-morpholin-4-yl-5-oxofuro[3,4-d]pyrimidin-2-yl)phenyl]-3-ethylurea	Ki	2.6 [1]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(1-methylpyrazol-4-yl)urea	IC50	4.3 [1], 6.0 [2]
	1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]phenyl]-3-(1-methylpyrazol-4-yl)urea	Ki	0.8 [1]
	6-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]anilino]-1H-pyridin-2-one	IC50	9.3 [1], 15.0 [2]
	6-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-5H-furo[3,4-d]pyrimidin-2-yl]anilino]-1H-pyridin-2-one	Ki	1.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mtor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase mTOR Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-mtor-inhibitors-ic50-ki.
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