Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(3E,5E)-3,5-Bis[(2-fluorophenyl)methylidene]piperidin-4-one	IC50	77000.0 [1]
	9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	32.0 [1]
	9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	2.5 [1]
	3,5-Bis(2-pyridylmethylene)piperidine-4-one	IC50	500.0 [1]
	(R)-9-(4-(1-Aminopropan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one	IC50	16.0 [1]
	(3Z,5Z)-3,5-Bis(pyridin-2-ylmethylidene)thian-4-one	IC50	14000.0 [1]
	(3E,5E)-1-Methyl-3,5-bis(pyridin-2-ylmethylidene)piperidin-4-one	IC50	3500.0 [1]
	CID 49837564	IC50	170.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	630.0 [1]
	Tilfrinib	IC50	10000.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	(3S,8S,9S,10R,13S,14S,17S)-17-Isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine	IC50	10000.0 [1]
	(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-one	IC50	11500.0 [1]
	1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic Acid	IC50	2600.0 [1]
	1-[3-Amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl]piperidine-4-carboxylic acid	IC50	22500.0 [1]
	N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamide	Ki	1000.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	1000.0 [1]
	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	IC50	83000.0 [1]
	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	IC50	83000.0 [1]
	(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	150.4 [1]
	8-Hydroxy-9-(1H-indazol-6-yl)thieno[2,3-c]quinolin-4(5H)-one	IC50	3.5 [1]
	9-[4-(Aminomethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	0.38 [1]
	8-[(3S)-3-Aminopyrrolidin-1-yl]-2-(4-hydroxyphenyl)-5H-thieno[2,3-c]quinolin-4-one	IC50	78.0 [1]
	4-(8-Hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzenesulfonamide	IC50	1.8 [1]
	N-[4-(8-Hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)phenyl]methanesulfonamide	IC50	2.6 [1]
	2-[4-(8-Hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)phenyl]acetonitrile	IC50	12.0 [1]
	8-Hydroxy-9-(1,2,3,6-tetrahydropyridin-4-yl)thieno[2,3-c]quinolin-4(5H)-one	IC50	0.78 [1]
	9-{4-[2-(Dimethylamino)ethyl]phenyl}-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	5.4 [1]
	9-[4-(Aminomethyl)phenyl]-8-hydroxy-2-methylthieno[2,3-c]quinolin-4(5H)-one	IC50	4.4 [1]
	9-[4-(1-Amino-2-methylpropan-2-yl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	72.0 [1]
	9-[4-(1-Aminoethyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	12.0 [1]
	9-[4-(2-Aminoethyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	19.0 [1]
	(R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	3.3 [1]
	9-[4-(2-Aminopropan-2-yl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	10.0 [1]
	9-[4-(Aminomethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	16.0 [1]
	9-[4-(1-Aminoethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	0.73 [1]
	9-[4-(2-Aminoethyl)phenyl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	1.1 [1]
	(E)-9-[3-(4-Aminopiperidin-1-yl)prop-1-enyl]-8-methoxythieno[2,3-c]quinolin-4(5H)-one	IC50	31.0 [1]
	9-[4-(1-Aminobutan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	15.0 [1]
	9-(4-Amino-3-hydroxyphenyl)-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	2.3 [1]
	9-[4-(2-Aminopropyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	41.0 [1]
	9-[4-[1-(Aminomethyl)cyclobutyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.7 [1]
	9-[4-(1-Aminoethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	12.0 [1]
	9-[4-(2-Aminoethyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	20.0 [1]
	9-[4-[(2R)-1-Aminopropan-2-yl]phenyl]-6-chloro-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	20.0 [1]
	9-[4-(1-Aminopropyl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	16.0 [1]
	8-Methoxy-9-{4-[(methylamino)methyl]phenyl}thieno[2,3-c]quinolin-4(5H)-one	IC50	7.8 [1]
	9-[4-(2-Aminoethyl)phenyl]-8-methoxythieno[2,3-c]quinolin-4(5H)-one	IC50	22.0 [1]
	9-[4-[1-(Diethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	4.5 [1]
	9-[4-(Aminomethyl)phenyl]-6-fluoro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	2.5 [1]
	9-[4-[(Dimethylamino)methyl]phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	11.0 [1]
	8-Hydroxy-9-[4-[(propan-2-ylamino)methyl]phenyl]-5H-thieno[2,3-c]quinolin-4-one	IC50	4.2 [1]
	9-[4-[1-(Dimethylamino)propyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.9 [1]
	8-Hydroxy-9-[4-(1-pyrrolidin-1-ylethyl)phenyl]-5H-thieno[2,3-c]quinolin-4-one	IC50	2.8 [1]
	9-[4-(Aminomethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	31.0 [1]
	9-[4-[3-[2-(Diethylamino)ethylamino]propoxy]phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	47.0 [1]
	9-[4-(1-Aminoethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	47.0 [1]
	9-[4-(2-Aminoethyl)phenyl]-6-bromo-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	45.0 [1]
	N-(1-Bromopropan-2-yl)-4-(8-hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)benzenesulfonamide	IC50	31.0 [1]
	9-[4-(Aminomethyl)phenyl]-6-fluoro-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	26.0 [1]
	9-[4-(1-Aminopropan-2-yl)-3-chlorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	10.0 [1]
	9-(4-Acetylphenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	23.0 [1]
	9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	18.0 [1]
	9-[4-[1-(Diethylamino)ethyl]-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	3.6 [1]
	9-[4-[(2S)-1-Aminopropan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	16.0 [1]
	9-[4-[1-(Aminomethyl)cyclopropyl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	9.6 [1]
	9-[4-(2-Aminopropyl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	37.0 [1]
	9-[4-[(2S)-1-(Dimethylamino)propan-2-yl]-3-fluorophenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	58.0 [1]
	9-[4-[1-(Dimethylamino)propan-2-yl]-3-fluorophenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	46.0 [1]
	9-[4-(1-Amino-2-methylpropan-2-yl)-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.0 [1]
	9-[4-(1-Amino-2-methylpropan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	39.0 [1]
	N-(2-Bromoethyl)-2-fluoro-4-(8-hydroxy-4-oxo-5H-thieno[2,3-c]quinolin-9-yl)benzenesulfonamide	IC50	13.0 [1]
	9-[4-(1-Aminopropyl)phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	5.2 [1]
	8-Hydroxy-9-{4-[(methylamino)methyl]phenyl}thieno[2,3-c]quinolin-4(5H)-one	IC50	0.9 [1]
	9-(4-(1-Aminopropan-2-yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-one	IC50	3.2 [1]
	9-[5-(Aminomethyl)thiophen-2-yl]-8-hydroxythieno[2,3-c]quinolin-4(5H)-one	IC50	0.78 [1]
	9-[4-(1-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	0.82 [1]
	9-[4-(3-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	0.74 [1]
	9-[4-(1-Aminopropan-2-yl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.3 [1]
	9-[4-[(2R)-1-Aminopropan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.3 [1]
	9-[4-[1-(Aminomethyl)cyclopropyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.9 [1]
	9-[4-(2-Aminopropyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.3 [1]
	9-[4-(2-Aminopropan-2-yl)phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	8.3 [1]
	9-[4-(1-Aminobutan-2-yl)phenyl]-6-chloro-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	19.0 [1]
	9-[4-[1-(Ethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	3.9 [1]
	8-Hydroxy-9-[4-[(2S)-1-(methylamino)propan-2-yl]phenyl]-5H-thieno[2,3-c]quinolin-4-one	IC50	2.8 [1]
	9-[4-[2-(Dimethylamino)ethyl]-3-fluorophenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.9 [1]
	9-[4-(2-Aminoethyl)-3-fluorophenyl]-8-methoxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	57.0 [1]
	3-[4-(8-Hydroxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenyl]propanenitrile	IC50	3.2 [1]
	6-Chloro-9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	43.0 [1]
	9-[4-[(2R)-1-[Ethyl(methyl)amino]propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	76.0 [1]
	9-[4-(Aminomethyl)phenyl]-4-oxo-5H-thieno[2,3-c]quinoline-8-carbonitrile	IC50	13.0 [1]
	(R)-9-(4-(1-Aminopropan-2-yl)phenyl)-8-methoxythieno[2,3-c]quinolin-4(5H)-one	IC50	2.0 [1]
	9-[4-(2-Amino-1-cyclopentylethyl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	4.6 [1]
	9-[4-[1-(Dimethylamino)ethyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.9 [1]
	9-[3-Fluoro-4-[3-methyl-1-(methylamino)butan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one	IC50	17.0 [1]
	9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-methoxy-5H-thieno[2,3-c]quinolin-4-one	IC50	4.1 [1]
	9-[4-[(Dimethylamino)methyl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	6.9 [1]
	9-[4-(1-Amino-3-methylbutan-2-yl)phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one	IC50	1.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase Nek1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek1-inhibitors-ic50-ki.
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