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Serine/threonine-protein kinase NEK2 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-[5-(1-Methylpiperidin-4-yl)oxybenzimidazol-1-yl]-2-[1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC50230.0 [1], 570.0 [2], 910.0 [3]
CID 49837564IC50200.0 [1], 230.0 [2], 300.0 [3]
4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Methoxybenzoic AcidIC501300.0 [1], 2400.0 [2], 2500.0 [3]
4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Methylbenzoic AcidIC501200.0 [1], 2300.0 [2], 2600.0 [3]
4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]benzoic AcidIC50710.0 [1], 1600.0 [2], 2300.0 [3]
1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic AcidIC50410.0 [1], 870.0 [2], 940.0 [3]
1-[3-Amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl]piperidine-4-carboxylic acidIC50720.0 [1], 1900.0 [2], 2100.0 [3]
5-[6-(1-Methylpiperidin-4-yl)oxybenzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamideIC5050.0 [1], 160.0 [2], 200.0 [3]
5-[6-(1-Methylpiperidin-4-yl)oxybenzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamideIC5025.0 [1]
N-[(3Z)-3-[(2-Ethyl-5-methyl-1H-imidazol-4-yl)methylidene]-2-oxo-1H-indol-5-yl]prop-2-ynamideIC50770.0 [1], 1300.0 [2]
CID 16662746IC506.0 [1], 14000.0 [2]
N-[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-5-yl]prop-2-ynamideIC50920.0 [1], 20000.0 [2]
QuercetinIC505730.0 [1]
StaurosporineIC504790.0 [1]
SunitinibIC5012000.0 [1]
NeratinibIC50274.0 [1]
PelitinibIC50661.0 [1]
5-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamideIC508000.0 [1]
NorlichexanthoneIC50100000.0 [1]
JNK Inhibitor VIIIKi920.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC50100000.0 [1]
CID 59604787IC5010000.0 [1]
2,3,6,8-Tetrahydroxy-1-methylxanthoneIC5083900.0 [1]
Epicoccolide BIC503780.0 [1]
Astrogorgiadiol BIC50100000.0 [1]
(1S,9R)-5,6,12,13,14-Pentahydroxy-4,11-dimethyl-16-oxo-8,17-dioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10,12,14-hexaene-3-carbaldehydeIC501830.0 [1]
(1R,3As,4S,5R,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,3a,4,5,6,7-octahydroinden-5-olIC50100000.0 [1]
Calicoferol BIC50100000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi920.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi9200.0 [1]
GSK 461364 analogue IIC5021.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi9242.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
Calicoferol EIC50100000.0 [1]
Khk-IN-1IC5040000.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi9200.0 [1]
3-(6-Methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridineIC503220.0 [1]
Ripk1-IN-7IC50268.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC5010000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC5010000.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC50310.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC501830.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
CID 71553154IC502510.0 [1]
TilfrinibIC5010000.0 [1]
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-oneIC50100000.0 [1]
Calicoferol AIC50100000.0 [1]
(1R,3As,4S,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,3a,4,6,7-hexahydro-1H-inden-5-oneIC50100000.0 [1]
Methyl 3-[[(1R,2S,4aR,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-4,5-dihydroxybenzoateIC5014700.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
4-[4-[3-[4-[(Propan-2-ylamino)methyl]anilino]-1H-pyrazol-5-yl]phenyl]benzene-1,3-diolIC501040.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
4-[7-(1-Methylpiperidin-4-yl)oxyimidazo[1,2-a]pyridin-3-yl]-2-phenylmethoxybenzamideIC50808.0 [1]
4-[7-(4-Methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC502170.0 [1]
4-[7-(1-Methylpiperidin-4-yl)oxyimidazo[1,2-a]pyridin-3-yl]-2-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC50591.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(3-fluorophenyl)methoxy]benzamideIC501.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-phenylmethoxybenzamideIC503.0 [1]
4-[7-(4-Methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-phenylmethoxybenzamideIC503210.0 [1]
N-Methyl-4-[7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC50197000.0 [1]
N-Hydroxy-4-[7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC5010000.0 [1]
Tert-butyl 4-[3-[4-carbamoyl-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]phenyl]imidazo[1,2-a]pyridin-7-yl]oxypiperidine-1-carboxylateIC5011190.0 [1]
4-(7-Piperidin-4-yloxyimidazo[1,2-a]pyridin-3-yl)-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamide;2,2,2-trifluoroacetic acidIC5010030.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(2-fluorophenyl)methoxy]benzamideIC5087.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[[3-(trifluoromethyl)phenyl]methoxy]benzamideIC507.0 [1]
4-[7-(4-Methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzoic acidIC5010030.0 [1]
4-[7-(1-Methylpiperidin-4-yl)oxyimidazo[1,2-a]pyridin-3-yl]-2-[1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC501600.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC50927.0 [1]
4-[7-(4-Methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC501190.0 [1]
4-[7-(4-Methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC502400.0 [1]
Tert-butyl 4-[3-[4-carbamoyl-3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]imidazo[1,2-a]pyridin-7-yl]oxypiperidine-1-carboxylateIC501037.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
Methyl 4-[7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[1-[2-(trifluoromethyl)phenyl]ethoxy]benzoateIC5042600.0 [1]
4-[7-(1-Methylpiperidin-4-yl)oxyimidazo[1,2-a]pyridin-3-yl]-2-[(1S)-1-[2-(trifluoromethyl)phenyl]ethoxy]benzamideIC5010000.0 [1]
4-(7-Chloroimidazo[1,2-a]pyridin-3-yl)-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC50200000.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[[4-(trifluoromethyl)phenyl]methoxy]benzamideIC50386.0 [1]
N-(2-Aminoethyl)-4-[7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC501300.0 [1]
4-[7-[1-[2-(Dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC50478.0 [1]
4-[7-(1-Methylpiperidin-4-yl)oxyimidazo[1,2-a]pyridin-3-yl]-2-[[2-(trifluoromethyl)phenyl]methoxy]benzamideIC50838.0 [1]
2-Methoxy-4-[7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]benzamideIC5019280.0 [1]
2-[Ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]ethanolIC50500.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
2-(5-Methoxy-3-oxo-1H-isoindol-2-yl)-N-(4-piperazin-1-ylpyridin-3-yl)-1,3-thiazole-4-carboxamideIC509500.0 [1]
N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(pyridin-2-ylmethyl)-1,2-thiazol-5-amineIC50500.0 [1]
4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Ethoxybenzoic AcidIC5016900.0 [1]
1-[3-Amino-6-(3-Methoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic AcidIC504200.0 [1]
1-(3-Amino-6-(3,4-dimethoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acidIC501900.0 [1]
1-(3-Amino-6-(3,5-dimethoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acidIC501900.0 [1]
1-(3-Amino-6-(4-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acidIC5019800.0 [1]
1-(3-Amino-6-phenylpyrazin-2-yl)piperidine-4-carboxylic acidIC507800.0 [1]
1-(3-Aminopyrazin-2-yl)piperidine-4-carboxylic acidIC5048500.0 [1]
3-(Piperidin-1-yl)-5-(3,4,5-trimethoxyphenyl)pyrazin-2-amineIC5050000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase NEK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase NEK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-nek2-inhibitors-ic50-ki.
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