Serine/threonine-protein kinase PAK 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	PF-03758309	IC50	13.7 [1], 14.0 [2]
	PF-03758309	Ki	15.0 [1], 36.0 [2], 39.0 [3]
	8-Chloro-3-fluoro-11-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepine	IC50	900.0 [1], 1000.0 [2], 6000.0 [3], 9000.0 [4], 25000.0 [5]
	CID 70934541	IC50	2.8 [1], 7.7 [2], 10.0 [3], 88.0 [4]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one	IC50	10.0 [1], 222.0 [2]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one	Ki	22.0 [1], 23.0 [2]
	1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanol	IC50	2000.0 [1], 5420.0 [2]
	1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanol	Ki	2900.0 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	69.0 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	3.7 [1]
	2-[[N-[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile	IC50	0.33 [1], 1.0 [2], 59.0 [3]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-methylpyrimidine-2,4-diamine	IC50	110.0 [1]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-methylpyrimidine-2,4-diamine	Ki	4.0 [1], 5.0 [2]
	4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine	IC50	120.0 [1]
	4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine	Ki	31.0 [1]
	[3-[[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-methylamino]-4-methylphenyl]methanol	IC50	2.1 [1], 490.0 [2], 540.0 [3]
	N~2~-[(trans-4-Aminocyclohexyl)methyl]-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-Diamine	IC50	2200.0 [1]
	N~2~-[(trans-4-Aminocyclohexyl)methyl]-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-Diamine	Ki	21.0 [1], 26.0 [2]
	Bis(2-hydroxy-1-naphthyl) disulfide	IC50	1000.0 [1], 2500.0 [2]
	CID 68060125	IC50	8.3 [1], 10.0 [2]
	[4-Methyl-3-[methyl-[2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanol	IC50	100.0 [1], 3100.0 [2]
	4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-N-(1H-indol-5-ylmethyl)pyrimidine-2,4-diamine	Ki	27.0 [1], 70.0 [2]
	4-[1-(4-Amino-1,3,5-Triazin-2-Yl)-2-(Ethylamino)-1h-Benzimidazol-6-Yl]-2-Methylbut-3-Yn-2-Ol	IC50	9600.0 [1]
	4-[1-(4-Amino-1,3,5-Triazin-2-Yl)-2-(Ethylamino)-1h-Benzimidazol-6-Yl]-2-Methylbut-3-Yn-2-Ol	Ki	4500.0 [1]
	CID 73348907	IC50	64.1 [1]
	CID 73348907	Ki	36.8 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	148.0 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	8.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	341.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	7.4 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)-8-[[5-(methylamino)-1,3-dioxan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	57.0 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)-8-[[5-(methylamino)-1,3-dioxan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	1.9 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-8-(5,9-dioxa-2-azaspiro[3.5]nonan-7-ylmethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	73.0 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-8-(5,9-dioxa-2-azaspiro[3.5]nonan-7-ylmethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	4.3 [1]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-ethylpyrimidine-2,4-diamine	IC50	85.0 [1]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-ethylpyrimidine-2,4-diamine	Ki	5.0 [1]
	(3R)-3-[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	IC50	7800.0 [1]
	(3R)-3-[3-[[2-[(4-Chloro-1H-benzimidazol-5-yl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	Ki	18.0 [1]
	(3R)-3-[3-[[2-[(4-Aminocyclohexyl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	IC50	10000.0 [1]
	(3R)-3-[3-[[2-[(4-Aminocyclohexyl)methyl-methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	Ki	37.0 [1]
	(3R)-3-[3-[[2-[(4-Aminocyclohexyl)methyl-ethylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	IC50	10000.0 [1]
	(3R)-3-[3-[[2-[(4-Aminocyclohexyl)methyl-ethylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]-1-methylpyrrolidin-2-one	Ki	49.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-(3-hydroxypropyl)pyrido[2,3-d]pyrimidin-7-one	IC50	980.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-(3-hydroxypropyl)pyrido[2,3-d]pyrimidin-7-one	Ki	64.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-[(2-oxopiperidin-4-yl)methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	813.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-[(2-oxopiperidin-4-yl)methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	66.0 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-8-[[(4S)-3,3-difluoropiperidin-4-yl]methyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	53.0 [1]
	6-[2-Chloro-4-(6-methylpyridin-2-yl)phenyl]-8-[[(4S)-3,3-difluoropiperidin-4-yl]methyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	7.9 [1]
	[5-[[5-Fluoro-2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-methylamino]-2,4-dimethylphenyl]methanol	IC50	3.0 [1], 220.0 [2]
	[5-[[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-methylamino]-2,4-dimethylphenyl]methanol	IC50	0.45 [1], 200.0 [2]
	[3-[[5-Fluoro-2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-methylamino]phenyl]methanol	IC50	45.0 [1], 14000.0 [2]
	[5-[[5-Fluoro-2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-methylamino]-2-methylphenyl]methanol	IC50	19.0 [1], 420.0 [2]
	[5-[[2-(3-Ethylsulfonyl-5-morpholin-4-ylanilino)-5-fluoropyrimidin-4-yl]-methylamino]-2,4-dimethylphenyl]methanol	IC50	2.8 [1], 270.0 [2]
	[3-[Benzyl-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]amino]-4-methylphenyl]methanol	IC50	1.5 [1], 230.0 [2]
	[3-[Ethyl-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]amino]-4-methylphenyl]methanol	IC50	2.0 [1], 530.0 [2]
	[3-[[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-[(2-fluorophenyl)methyl]amino]-4-methylphenyl]methanol	IC50	0.35 [1], 130.0 [2]
	[5-[[5-Fluoro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-methylamino]-2,4-dimethylphenyl]methanol	IC50	33.0 [1], 2100.0 [2]
	[5-[[2-[3-Ethylsulfonyl-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-5-fluoropyrimidin-4-yl]-methylamino]-2,4-dimethylphenyl]methanol	IC50	0.58 [1], 110.0 [2]
	[3-[[5-Fluoro-2-[4-(4-methylpiperazin-1-yl)-3-methylsulfonylanilino]pyrimidin-4-yl]-methylamino]-4-methylphenyl]methanol	IC50	8.7 [1], 810.0 [2]
	5-Fluoro-4-N-[5-(methoxymethyl)-2-methylphenyl]-4-N-methyl-2-N-(3-methylsulfonyl-5-morpholin-4-ylphenyl)pyrimidine-2,4-diamine	IC50	189.0 [1], 3300.0 [2]
	[3-[[5-Fluoro-2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-methylamino]-4-methylphenyl]methanol	IC50	14.0 [1], 860.0 [2]
	[4-Chloro-3-[[5-fluoro-2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-methylamino]phenyl]methanol	IC50	9.6 [1], 480.0 [2]
	2,8-Difluoro-11-(4-Methylpiperazin-1-Yl)-5h-Dibenzo[b,E][1,4]diazepine	IC50	12000.0 [1], 54000.0 [2]
	4-N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine	IC50	133.0 [1]
	4-N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine	Ki	6.75 [1]
	2-N-[(1S)-1-(3H-Benzimidazol-5-yl)ethyl]-4-N-[5-(2,2-difluorocyclopropyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine	IC50	244.0 [1]
	2-N-[(1S)-1-(3H-Benzimidazol-5-yl)ethyl]-4-N-[5-(2,2-difluorocyclopropyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine	Ki	5.13 [1]
	2-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]-[(6-fluoro-1H-indazol-4-yl)methyl]amino]propan-1-ol	IC50	70.8 [1]
	2-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]-[(6-fluoro-1H-indazol-4-yl)methyl]amino]propan-1-ol	Ki	4.2 [1]
	2-N-[(1S)-1-(3H-Benzimidazol-5-yl)ethyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine	IC50	281.0 [1]
	2-N-[(1S)-1-(3H-Benzimidazol-5-yl)ethyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine	Ki	12.0 [1]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine	IC50	362.0 [1]
	2-N-[(4-Chloro-1H-benzimidazol-5-yl)methyl]-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine	Ki	5.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	124.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	1.9 [1]
	8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	147.0 [1]
	8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	6.1 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-(piperidin-4-ylmethyl)pyrido[2,3-d]pyrimidin-7-one	IC50	145.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)-8-(piperidin-4-ylmethyl)pyrido[2,3-d]pyrimidin-7-one	Ki	6.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	399.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	19.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	45.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	2.1 [1]
	(2-Chlorophenyl)-[5-(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methanone	IC50	1.0 [1], 140.0 [2]
	(2-Chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methanone	IC50	18.0 [1], 870.0 [2]
	(2-Chlorophenyl)-[5-(2-methyl-1,3-dihydroisoindol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methanone	IC50	33.0 [1], 1100.0 [2]
	(2-Chlorophenyl)-[5-(2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methanone	IC50	4.5 [1], 650.0 [2]
	1-[6-[3-(2-Chlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dihydro-1H-isoquinolin-2-yl]ethanone	IC50	270.0 [1], 1300.0 [2]
	5-[2-Chloro-4-(1,3-thiazol-5-yl)phenyl]-3-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-one	IC50	2.8 [1], 88.0 [2]
	Curcumin	IC50	16000.0 [1]
	Staurosporine	IC50	0.3 [1]
	Resveratrol	IC50	15000.0 [1]
	Ketorolac	IC50	36000.0 [1]
	Sepantronium bromide	IC50	500.0 [1]
	Artepillin C	IC50	25000.0 [1]
	Azd-1152hqpa	Ki	10000.0 [1]
	1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone	IC50	2500.0 [1]
	JNK Inhibitor VIII	Ki	9700.0 [1]
	6-Morpholin-4-Yl-9h-Purine	IC50	18000.0 [1]
	N-Cyclopentyl-9H-purin-6-amine	IC50	18000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PAK 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase PAK 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-inhibitors-ic50-ki.
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