Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one	IC50	220.0 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	71.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	290.0 [1]
	8-(3-Amino-2,2-difluoropropyl)-6-[2-chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	460.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-[(3,3-difluoropiperidin-4-yl)methyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	78.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[2-(1-methylazetidin-3-yl)oxyethyl]pyrido[2,3-d]pyrimidin-7-one	IC50	88.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-[2-(3-fluoro-1-methylazetidin-3-yl)ethyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	33.0 [1]
	8-(3-Aminopropyl)-6-[2-chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	602.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-ethyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	340.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-ethyl-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	150.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-hydroxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	930.0 [1]
	6-[2-Cyclopropyl-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2S)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	15000.0 [1]
	6-[2-Chloro-4-(4-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	30000.0 [1]
	6-[2-Chloro-4-(3-ethyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	240.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyrazin-1-yl)phenyl]-8-[(3,3-difluoropiperidin-4-yl)methyl]-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	280.0 [1]
	6-[2-Chloro-4-(5-methyl-6-oxopyrimidin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	800.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-one	IC50	6000.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	450.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 18 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-pak-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase PAK 1/PAK 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-1-pak-2-inhibitors-ic50-ki.
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