Serine/threonine-protein kinase PAK 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	1.0 [1], 2.59 [2]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	IC50	11.0 [1]
	8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	11.0 [1]
	Ceritinib	IC50	10000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Sotrastaurin	IC50	10000.0 [1]
	PF-03758309	IC50	190.0 [1]
	CID 70934541	IC50	12.8 [1]
	CID 68060125	IC50	39.5 [1]
	4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide	IC50	25000.0 [1]
	CID 44814409	IC50	10000.0 [1]
	1-({1-(2-Aminopyrimidin-4-Yl)-2-[(2-Methoxyethyl)amino]-1h-Benzimidazol-6-Yl}ethynyl)cyclohexanol	IC50	970.0 [1]
	6-[2-Chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-one	Ki	48.0 [1]
	2-[[N-[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile	IC50	6.0 [1]
	3-(6-Methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine	IC50	30000.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	4-Methyl-3-[2-(methylamino)quinazolin-6-yl]-N-[2-(1-methylpiperidin-4-yl)oxy-5-(trifluoromethyl)phenyl]benzamide	IC50	25000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	IC50	10000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	CID 73348907	IC50	64.1 [1]
	Tilfrinib	IC50	10000.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamide	IC50	10000.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-[2-(3-fluoro-1-methylazetidin-3-yl)ethyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	2.0 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-8-ethyl-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	21.0 [1]
	6-[2-Cyclopropyl-4-(3-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2S)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	3670.0 [1]
	6-[2-Chloro-4-(4-methyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	2300.0 [1]
	6-[2-Chloro-4-(3-ethyl-2-oxopyridin-1-yl)phenyl]-2-(methylamino)-8-[[(2R)-morpholin-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Ki	9.5 [1]
	6-[2-Chloro-4-(3-methyl-2-oxopyrazin-1-yl)phenyl]-8-[(3,3-difluoropiperidin-4-yl)methyl]-2-(oxetan-3-ylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	4.6 [1]
	6-[2-Chloro-4-(5-methyl-6-oxopyrimidin-1-yl)phenyl]-8-(2-methoxyethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one	Ki	39.0 [1]
	8-[(4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-one	Ki	940.0 [1]
	2-Methyl-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide	IC50	25000.0 [1]
	(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-one	IC50	100000.0 [1]
	Infigratinib phosphate	IC50	10000.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	1000.0 [1]
	4-N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(1H-indol-5-yl)ethyl]pyrimidine-2,4-diamine	IC50	133.0 [1]
	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]urea	IC50	10000.0 [1]
	2-N-[(1S)-1-(3H-Benzimidazol-5-yl)ethyl]-4-N-[5-(2,2-difluorocyclopropyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine	IC50	244.0 [1]
	2-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]-[(6-fluoro-1H-indazol-4-yl)methyl]amino]propan-1-ol	IC50	70.8 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 42 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PAK 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase PAK 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pak-2-inhibitors-ic50-ki.
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