Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(3R,5S)-3,5-Diamino-1-[3-[[2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-4-ol	IC50	115.0 [1]
	(3S,5R)-3,5-Diamino-1-[3-[[2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-4-ol	IC50	31.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-chlorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	2668.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,4-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	1761.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-fluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	1536.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(1,3-thiazol-2-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	602.0 [1]
	N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	28.0 [1]
	N-[4-[(3S,4S)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	2982.0 [1]
	N-[4-[(3S,4R)-3-Amino-4-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	212.0 [1]
	N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	45.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	403.0 [1]
	(3S)-1-[3-[[2-(2,6-Difluorophenyl)imidazo[1,5-b]pyridazin-7-yl]amino]pyridin-4-yl]piperidin-3-ol	IC50	4807.0 [1]
	N-[4-[(3S,5R)-3-Amino-5-fluoropiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	983.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(3-chloropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	620.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	286.0 [1]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	5120.0 [1]
	N-[4-[(2S,3S)-3-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	2530.0 [1]
	N-[4-[(2R,3S)-3-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	221.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,4-dichlorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	5007.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-pyridin-2-ylimidazo[1,5-b]pyridazin-7-amine	IC50	1760.0 [1]
	N-[4-[(3S,5S)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	522.0 [1]
	N-[2-[(3S)-3-Aminopiperidin-1-yl]phenyl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	3440.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2-fluoropyridin-3-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	6599.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyrimidin-5-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	15800.0 [1]
	N-[4-[(3R,4R)-3-Amino-4-fluoropiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	6100.0 [1]
	N-[4-[(2R,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(3-fluoropyridin-2-yl)imidazo[1,5-b]pyridazin-7-amine	IC50	258.0 [1]
	2-(3-Anilino-2-methylquinoxalin-5-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one	IC50	184.0 [1]
	Macrocyclic Quinoxaline-Pyrrolodihydropiperidinone	IC50	25.0 [1]
	(9S,13S)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	40.0 [1]
	(9S,11Z)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	14.0 [1]
	(9S,11E)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	16.0 [1]
	(9R)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	100.0 [1]
	(9S,11E)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	106.0 [1]
	(9S,11E,13S)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	26.0 [1]
	(9S)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	20.0 [1]
	(9S,11E,13R)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	20.0 [1]
	(9R,11E)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	880.0 [1]
	(9R,11Z)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	370.0 [1]
	(9S,11Z)-16-Methyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,11,15(23),16,18,20-octaen-6-one	IC50	21.0 [1]
	(9S,13R)-13,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	37.0 [1]
	(9S,12R)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	25.0 [1]
	(9S,12S)-12,16-Dimethyl-3,7,14,17,23-pentazapentacyclo[13.6.2.12,5.04,9.018,22]tetracosa-1(22),2(24),4,15(23),16,18,20-heptaen-6-one	IC50	37.0 [1]
	N-[4-[(2R,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	49.0 [1]
	N-[4-[(2S,5S)-5-Amino-2-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine	IC50	142.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 44 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Serine/threonine-protein kinase PIM Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim-inhibitors-ic50-ki.
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