Serine/threonine-protein kinase PIM3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione	IC50	1.9 [1], 3.0 [2], 9.0 [3]
	(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione	Ki	0.23 [1]
	N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine	IC50	69.0 [1]
	N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine	Ki	24.0 [1]
	1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde	IC50	10.0 [1]
	CID 46179018	IC50	1.0 [1]
	CID 46179018	Ki	0.0 [1], 1.0 [2], 3.0 [3]
	CID 44814409	IC50	2.0 [1]
	CID 44814409	Ki	0.01 [1], 3.0 [2]
	(2z)-2-(1h-Indazol-3-Ylmethylidene)-6-Methoxy-7-(Piperazin-1-Ylmethyl)-1-Benzofuran-3(2h)-One	IC50	13.0 [1], 25.0 [2]
	2-(Acetylamino)-N-[2-(Piperidin-1-Yl)phenyl]-1,3-Thiazole-4-Carboxamide	Ki	230.0 [1]
	3-Amino-N-[4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl]-6-(2-fluorophenyl)pyridine-2-carboxamide	Ki	1.0 [1], 3.0 [2]
	(3S)-1-[6-[5-(1-Methylpyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl]pyridin-2-yl]piperidin-3-amine	Ki	0.01 [1], 0.02 [2]
	N-[6-[3-(2-Aminopyrimidin-4-yl)-1H-indol-5-yl]pyrazin-2-yl]-N',N'-dimethylethane-1,2-diamine	IC50	6.5 [1], 7.0 [2]
	N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	IC50	2.0 [1]
	N-[4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	Ki	3.0 [1]
	N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	IC50	3.0 [1]
	N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	Ki	4.0 [1]
	1-(1,10-Dihydropyrrolo[2,3-a]carbazol-3-yl)-2,2,2-trifluoroethanone	IC50	170.0 [1]
	7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole	IC50	440.0 [1]
	7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde	IC50	40.0 [1]
	1,10-Dihydropyrrolo[2,3-a]carbazole-3-carboxamide	IC50	210.0 [1]
	7-(2,4-Difluorophenyl)-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde	IC50	200.0 [1]
	(R,Z)-5-(2-(3-Aminopiperidin-1-yl)-3-chlorobenzylidene)thiazolidine-2,4-dione	IC50	3.0 [1], 20.0 [2]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-methoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	3.0 [1], 10.0 [2]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-bromophenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	3.0 [1], 10.0 [2]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-ethoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	3.0 [1], 6.0 [2]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-(2-methylpropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	3.0 [1]
	(5z)-5-{2-[(3r)-3-Aminopiperidin-1-Yl]-3-(Propan-2-Yloxy)benzylidene}-1,3-Thiazolidine-2,4-Dione	IC50	3.0 [1]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	9.0 [1], 240.0 [2]
	N-[4-[(1R,3R,4R,5S)-3-Amino-4-hydroxy-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	IC50	2.0 [1]
	N-[4-[(1R,3R,4R,5S)-3-Amino-4-hydroxy-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	Ki	3.0 [1]
	3-Amino-N-[4-[(1R,3S)-3-aminocyclohexyl]pyridin-3-yl]-6-cyclohexylpyridine-2-carboxamide	IC50	14.0 [1]
	3-Amino-N-[4-[(1R,3S)-3-aminocyclohexyl]pyridin-3-yl]-6-cyclohexylpyridine-2-carboxamide	Ki	14.0 [1]
	N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-5-fluoro-6-(2-fluorophenyl)pyridine-2-carboxamide	IC50	2.0 [1]
	N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-5-fluoro-6-(2-fluorophenyl)pyridine-2-carboxamide	Ki	3.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	IC50	2.0 [1]
	N-[4-[(3S)-3-Aminopiperidin-1-yl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	Ki	3.0 [1]
	4-[[3-[3-(Trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-ol	IC50	55.0 [1], 83.0 [2]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	IC50	3.0 [1]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	Ki	3.0 [1]
	3-Amino-N-[4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	IC50	1.0 [1]
	3-Amino-N-[4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide	Ki	0.0 [1]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	IC50	4.0 [1]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide	Ki	4.0 [1]
	5-[3-(6-Cyclopentyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	4.58 [1], 5.0 [2]
	5-[3-(6-Cyclohexyloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	17.78 [1], 18.0 [2]
	5-(3-(6-Ethoxypyrazin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine	IC50	7.8 [1], 8.0 [2]
	5-(3-Quinolin-3-yl-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine	IC50	178.0 [1], 178.73 [2]
	5-[3-(6-Ethoxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	3.0 [1], 3.25 [2]
	5-[3-[6-(Cyclopentylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	0.76 [1], 1.0 [2]
	5-(3-(6-Morpholinopyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine	IC50	6.0 [1], 44.36 [2]
	5-(3-(6-(1-Pyrrolidinyl)-2-pyridinyl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine	IC50	14.47 [1], 15.0 [2]
	5-[3-(6-Cyclopentyloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	10.66 [1], 11.0 [2]
	6-[5-(5-Amino-1,3,4-Thiadiazol-2-Yl)-1h-Indol-3-Yl]-N-Cyclopentylpyridin-2-Amine	IC50	5.0 [1], 5.07 [2]
	5-[3-(2,6-Difluorophenyl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	96.65 [1], 97.0 [2]
	5-[3-[6-(Cyclohexylamino)pyridin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	21.56 [1], 22.0 [2]
	5-[3-(6-Propan-2-yloxypyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	3.0 [1], 185.31 [2]
	5-[3-(6-Propan-2-yloxypyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	1.58 [1], 2.0 [2]
	5-[3-(6-Aminopyridin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	185.63 [1], 186.0 [2]
	5-[3-[6-(Propan-2-ylamino)pyridin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	5.0 [1], 5.42 [2]
	6-[5-(5-Amino-1,3,4-thiadiazol-2-yl)-1H-indol-3-yl]-2-Pyrazinamine	IC50	28.7 [1], 29.0 [2]
	5-[3-[6-(Cyclohexylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	1.99 [1], 2.0 [2]
	5-[3-(6-Morpholin-4-ylpyrazin-2-yl)-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	4.0 [1], 4.38 [2]
	N-Methyl-5-(3-quinolin-3-yl-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine	IC50	181.0 [1], 181.02 [2]
	(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-pyridin-4-ylphenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	4.0 [1], 38.0 [2]
	1-[6-(1,4-Diazepan-1-yl)pyridin-2-yl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine	Ki	0.02 [1]
	(3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amine	Ki	0.01 [1]
	5-(3-(Quinolin-3-yl)-1H-indol-5-yl)thiazol-2-amine	IC50	267.0 [1], 267.02 [2]
	5-[3-[6-(Propan-2-ylamino)pyrazin-2-yl]-1H-indol-5-yl]-1,3,4-thiadiazol-2-amine	IC50	1.0 [1], 1.15 [2]
	N-[4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl]-5-fluoro-6-(4-hydroxycyclohexyl)pyridine-2-carboxamide	IC50	24.0 [1], 30.0 [2]
	N-[4-[(1R,3S)-3-Aminocyclohexyl]pyridin-3-yl]-5-fluoro-6-(4-hydroxycyclohexyl)pyridine-2-carboxamide	IC50	65.0 [1], 102.0 [2]
	Staurosporine	IC50	0.12 [1]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	1400.0 [1]
	Harmine	IC50	4300.0 [1]
	N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide	IC50	880.0 [1]
	N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine;sulfuric acid	IC50	69.0 [1]
	3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol	IC50	100.0 [1]
	JNK Inhibitor V	IC50	30.0 [1]
	CID 44545852	IC50	16.0 [1]
	2,4-Thiazolidinedione, 5-(phenylmethylene)-, (5Z)-	IC50	730.0 [1]
	5-(3,4-Dimethoxybenzylidene)thiazolidine-2,4-dione	IC50	280.0 [1]
	CID 72163809	IC50	150.0 [1]
	8-Bromo[1]benzofuro[3,2-d]pyrimidin-4(3H)-one	IC50	346.0 [1]
	CID 44222958	IC50	86.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	(2Z)-6-Methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-1-benzofuran-3-one	IC50	1.3 [1]
	4-Chloro-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide	IC50	400.0 [1]
	6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one	Ki	11.0 [1]
	8-Bromanyl-2-[[(3s)-3-Oxidanylpyrrolidin-1-Yl]methyl]-3h-[1]benzofuro[3,2-D]pyrimidin-4-One	IC50	10.0 [1]
	2-[[(3R)-3-Aminopyrrolidin-1-yl]methyl]-8-bromo-3H-[1]benzofuro[3,2-d]pyrimidin-4-one	IC50	6.0 [1]
	2-[[(3S)-3-Aminopyrrolidin-1-yl]methyl]-8-bromo-3H-[1]benzofuro[3,2-d]pyrimidin-4-one	IC50	11.0 [1]
	8-Bromo-2-(pyrrolidin-1-ylmethyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one	IC50	12.0 [1]
	N-[4-(8-Bromo-4-oxo-3H-[1]benzofuro[3,2-d]pyrimidin-2-yl)-3-chlorophenyl]-3-piperidin-1-ylpropanamide	IC50	5.0 [1]
	8-Bromo-2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one	IC50	4.0 [1]
	2-(Azetidin-1-ylmethyl)-8-bromo[1]benzofuro[3,2-d]pyrimidin-4(3H)-one	IC50	10.0 [1]
	8-Bromo-2-[2-chloro-4-[(piperidin-4-ylamino)methyl]phenyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one	IC50	8.0 [1]
	8-Bromo-2-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.2]octan-2-yl]methyl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one	IC50	18.0 [1]
	(Z)-5-(3-Ethoxy-4-hydroxybenzylidene)thiazolidine-2,4-dione	IC50	390.0 [1]
	STO-609 acetate	IC50	83.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase PIM3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase PIM3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-pim3-inhibitors-ic50-ki.
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