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Serine/threonine-protein kinase PLK2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
StaurosporineIC50197.0 [1], 365.9 [2], 957.2 [3]
BI-2536IC5013.55 [1], 30.0 [2]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-(8-phenyloctyl)imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50130.0 [1], 570.0 [2]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1], 100000.0 [2]
1-Methyl-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC503519.0 [1]
8-[5-Amino-2-(trifluoromethoxy)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC501280.0 [1], 1282.0 [2]
1-Methyl-8-[5-[2-(1-methylpyrrolidin-2-yl)ethylamino]-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50429.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC50310.0 [1], 374.0 [2]
(7R)-7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(1-methylpyrazol-4-yl)-7H-pteridin-6-oneIC5021.0 [1], 780.0 [2]
(7R)-7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(1-methylpyrazol-3-yl)-7H-pteridin-6-oneIC507.0 [1], 480.0 [2]
(7R)-7-Ethyl-5-methyl-8-(oxan-4-yl)-2-[5-(1,3-thiazol-2-yl)-1H-pyrazol-4-yl]-7H-pteridin-6-oneIC5036.0 [1], 2990.0 [2]
(7R)-7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(1H-pyrazol-4-yl)-7H-pteridin-6-oneIC5012.0 [1], 1870.0 [2]
7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(1H-pyrazol-5-yl)-7H-pteridin-6-oneIC509.0 [1], 740.0 [2]
(7R)-7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-(3,3,3-trifluoropropyl)-7H-pteridin-6-oneIC5042.0 [1], 2560.0 [2]
(7R)-7-Ethyl-5-methyl-8-(1H-pyrazol-4-yl)-2-[5-(1,3-thiazol-2-yl)-1H-pyrazol-4-yl]-7H-pteridin-6-oneIC5092.0 [1], 5820.0 [2]
(7R)-7-Ethyl-2-[2-(4-fluorophenyl)imidazol-1-yl]-5-methyl-8-[(3S)-oxolan-3-yl]-7H-pteridin-6-oneIC5033.0 [1], 2050.0 [2]
(7R)-7-Ethyl-5-methyl-8-[(3S)-oxolan-3-yl]-2-[5-(1,3-thiazol-2-yl)-1H-pyrazol-4-yl]-7H-pteridin-6-oneIC5039.0 [1], 3190.0 [2]
ThymoquinoneIC5014720.0 [1]
AxitinibIC5010000.0 [1]
DoramapimodIC5030000.0 [1]
Pha-793887IC5010000.0 [1]
CFI-400945 (free base)IC5050000.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
1-(4-Methoxyphenyl)-3-[(2-oxo-3-indolyl)amino]thioureaIC5050000.0 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50238.0 [1]
3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-[1,2]oxazolo[5,4-c]pyridin-5-amineIC504.0 [1]
8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC509.0 [1]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
2-Pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamideIC5010000.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-(2-fluoro-6-phenoxyphenyl)octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50290.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
1-Methyl-8-(2-methylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC502.0 [1]
8-(2-Methoxyanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5024.0 [1]
1-Methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamideIC50206.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
(2'S,3R)-2'-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC50100000.0 [1]
N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamideIC5010000.0 [1]
3-[(1R)-1-[4-[(Tert-butylamino)methyl]-2-(difluoromethoxy)phenyl]ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamideIC5021.0 [1]
3-[(E)-Benzotriazol-5-ylidenemethyl]-1H-indol-2-olIC508900.0 [1]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-5-methoxy-1H-indol-2-olIC5010000.0 [1]
(E)-3-((1H-Indazol-6-yl)methylene)indolin-2-oneIC505700.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Methyl-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Chloro-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-[3-[(E)-2-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Fluoro-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-2-olIC504400.0 [1]
4-[(E)-2-[(6E)-6-[(2-Hydroxy-1H-indol-3-yl)methylidene]indazol-3-yl]ethenyl]benzoic acidIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indole-2,5-diolIC5010000.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
6-Chloro-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-2-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Chloro-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
N-[2-Hydroxy-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-6-yl]acetamideIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Phenylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-Indazol-6-ylidenemethyl]-5-methoxy-1H-indol-2-olIC5010000.0 [1]
3-[(Z)-Indazol-5-ylidenemethyl]-1H-indol-2-olIC501900.0 [1]
5-Fluoro-3-[(Z)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
N-[2-Hydroxy-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-5-yl]acetamideIC5010000.0 [1]
5-Ethyl-3-[(E)-[3-[(E)-2-pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-phenylmethoxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50250.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-hydroxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC503400.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-phenylmethoxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC503500.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-hydroxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50310.0 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(3-hydroxypropyl)benzenesulfonamideIC508.16 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamideIC503.4 [1]
N-Cyclopentyl-4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC5023.87 [1]
N-Butyl-4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC5019.85 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-phenylbenzenesulfonamideIC5054.4 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(2-hydroxyethyl)benzenesulfonamideIC50478.3 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-propan-2-ylindole-5-carboxamideIC50124.5 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC50384.3 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-(2-methylpropyl)indole-5-carboxamideIC5018.62 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-(2-methylpropyl)indole-5-carboxamideIC50158.8 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-ethylindole-5-carboxamideIC504.88 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-propan-2-ylindole-5-carboxamideIC5017.41 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamideIC5071.55 [1]
(7R)-8-Cyclopentyl-7-ethyl-2-(5-fluoroindol-1-yl)-5-methyl-7H-pteridin-6-oneIC50969.2 [1]
N-Ethyl-1-[7-ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC50242.5 [1]
7-Ethyl-2-(5-fluoroindol-1-yl)-5-methyl-8-(1-methylpyrazol-3-yl)-7H-pteridin-6-oneIC501500.0 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-propylbenzenesulfonamideIC50189.6 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(2-methylpropyl)benzenesulfonamideIC50311.0 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC5010.17 [1]
N-Butyl-1-[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC5016.52 [1]
N-Butyl-1-[7-ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC50159.0 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-methylindole-5-carboxamideIC50217.7 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC5028.51 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-methylindole-5-carboxamideIC508.6 [1]
N-Cyclopentyl-1-[7-ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC5090.93 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC50120.6 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-propylindole-5-carboxamideIC5011.35 [1]
(3S)-3-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-[(2S)-2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phosphonooxybutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-oxobutanoic acidIC5013370.0 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(2-methylpropyl)benzenesulfonamideIC5021.77 [1]
(3S)-3-[[(2S)-2-Acetamido-3-(3,4-dichlorophenyl)propanoyl]amino]-4-[(2S)-2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1,4-diamino-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phosphonooxybutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-oxobutanoic acidIC50715.7 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-propylindole-5-carboxamideIC50206.7 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(2-hydroxyethyl)benzenesulfonamideIC507.86 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-propylbenzenesulfonamideIC5017.77 [1]
N-Cyclopentyl-1-[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC507.06 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(3-hydroxypropyl)benzenesulfonamideIC50192.0 [1]
N-Butyl-4-[[7-ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC50190.7 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PLK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Serine/threonine-protein kinase PLK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk2-inhibitors-ic50-ki.
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