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Serine/threonine-protein kinase PLK3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
Lfm-a13IC5061000.0 [1]
WortmanninIC5048.0 [1], 49.0 [2], 220.0 [3]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC503000.0 [1], 88000.0 [2]
BI-2536IC5020.78 [1], 90.0 [2]
5-(5,6-Dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamideIC509.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-(8-phenyloctyl)imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50280.0 [1], 1200.0 [2]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1], 100000.0 [2]
1-Methyl-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC501439.0 [1]
8-[5-Amino-2-(trifluoromethoxy)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50154.0 [1]
1-Methyl-8-[5-[2-(1-methylpyrrolidin-2-yl)ethylamino]-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50485.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
StaurosporineIC5010000.0 [1]
ThymoquinoneIC5050000.0 [1]
AxitinibIC5010000.0 [1]
DoramapimodIC5030000.0 [1]
CFI-400945 (free base)IC5050000.0 [1]
JNK Inhibitor VIIIKi8000.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
CID 59604787IC5010000.0 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC50450.0 [1]
3-[(2-Chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamideIC509.0 [1]
CID 11328632IC5030.0 [1]
5-[6-(1-Methylpiperidin-4-yl)oxybenzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamideIC50270.0 [1]
3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-[1,2]oxazolo[5,4-c]pyridin-5-amineIC5024.0 [1]
8-Anilino-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5014.0 [1]
Benz[b]indeno[1,2-e]pyran-6,11-dioneIC508970.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi8000.0 [1]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi8000.0 [1]
GSK 461364 analogue IIC50630.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1085.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
Khk-IN-1IC5040000.0 [1]
2-Pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamideIC5050000.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi820.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi560.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi8000.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi8000.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi8000.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi8000.0 [1]
5-[5,6-Bis(Methyloxy)-1h-Benzimidazol-1-Yl]-3-{[1-(2-Chlorophenyl)ethyl]oxy}-2-ThiophenecarboxamideIC506.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-(2-fluoro-6-phenoxyphenyl)octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC501450.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
1-Methyl-8-(2-methylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC506.0 [1]
3-Methyl-N-[6-methylsulfanyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC50785.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC5010000.0 [1]
3-[(1R)-1-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]ethyl]-N-[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amineIC5010.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC501000.0 [1]
8-(2-Methoxyanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5013.0 [1]
1-Methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamideIC5032.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
(2'S,3R)-2'-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-oneIC50100000.0 [1]
3-[(1R)-1-[4-[(Tert-butylamino)methyl]-2-(difluoromethoxy)phenyl]ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamideIC50178.0 [1]
3-[5-Chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamideIC5010000.0 [1]
5-Methyl-5,11-dihydro-6H-indeno[2,1-b]quinoline-6,11-dioneIC50200000.0 [1]
3-[(E)-Benzotriazol-5-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-5-methoxy-1H-indol-2-olIC5010000.0 [1]
(E)-3-((1H-Indazol-6-yl)methylene)indolin-2-oneIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Methyl-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Chloro-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-[3-[(E)-2-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
4-[(E)-2-[(6E)-6-[(2-Hydroxy-1H-indol-3-yl)methylidene]indazol-3-yl]ethenyl]benzoic acidIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indole-2,5-diolIC5010000.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
6-Chloro-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Pyridin-2-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Chloro-3-[(E)-[3-[(E)-2-pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
5-Methoxy-3-[(E)-[3-[(E)-2-pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
N-[2-Hydroxy-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-6-yl]acetamideIC5010000.0 [1]
3-[(E)-[3-[(E)-2-Phenylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
3-[(E)-Indazol-6-ylidenemethyl]-5-methoxy-1H-indol-2-olIC5010000.0 [1]
3-[(Z)-Indazol-5-ylidenemethyl]-1H-indol-2-olIC5011000.0 [1]
5-Fluoro-3-[(Z)-indazol-6-ylidenemethyl]-1H-indol-2-olIC5024000.0 [1]
N-[2-Hydroxy-3-[(E)-indazol-6-ylidenemethyl]-1H-indol-5-yl]acetamideIC5010000.0 [1]
5-Ethyl-3-[(E)-[3-[(E)-2-pyridin-3-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC5010000.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-phenylmethoxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50920.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-hydroxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC501900.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[2-fluoro-6-(3-phenylmethoxyphenoxy)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC5029500.0 [1]
[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-[3-[8-[4-(2-hydroxyethyl)phenyl]octyl]imidazol-4-yl]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-amino-4-oxobutan-2-yl] dihydrogen phosphateIC50960.0 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(3-hydroxypropyl)benzenesulfonamideIC50165.3 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamideIC5038.52 [1]
N-Cyclopentyl-4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC50742.8 [1]
N-Butyl-4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC50245.6 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-phenylbenzenesulfonamideIC502403.0 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(2-hydroxyethyl)benzenesulfonamideIC50482.8 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-propan-2-ylindole-5-carboxamideIC5010000.0 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC5010000.0 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-(2-methylpropyl)indole-5-carboxamideIC502789.0 [1]
1-[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]-N-(2-methylpropyl)indole-5-carboxamideIC5010000.0 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-ethylindole-5-carboxamideIC504442.0 [1]
1-[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]-N-propan-2-ylindole-5-carboxamideIC5010000.0 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamideIC501263.0 [1]
(7R)-8-Cyclopentyl-7-ethyl-2-(5-fluoroindol-1-yl)-5-methyl-7H-pteridin-6-oneIC5020000.0 [1]
N-Ethyl-1-[7-ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]indole-5-carboxamideIC5010000.0 [1]
7-Ethyl-2-(5-fluoroindol-1-yl)-5-methyl-8-(1-methylpyrazol-3-yl)-7H-pteridin-6-oneIC5010000.0 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-propylbenzenesulfonamideIC501550.0 [1]
4-[[7-Ethyl-5-methyl-8-(1-methylpyrazol-3-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(2-methylpropyl)benzenesulfonamideIC501902.0 [1]
4-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamideIC5080.72 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase PLK3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase PLK3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-plk3-inhibitors-ic50-ki.
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