Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	2.5 [1]
	Sorafenib	IC50	3300.0 [1]
	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	IC50	2800.0 [1]
	1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene	IC50	290.0 [1]
	Oroidin	IC50	2500.0 [1]
	Hymenialdisine	IC50	6.0 [1]
	10Z-Hymenialdisine	IC50	3.0 [1]
	Debromohymenialdisine	IC50	881.0 [1]
	Src Kinase Inhibitor I	IC50	100000.0 [1]
	4,5-Dibromo-1h-pyrrole-2-carboxamide	IC50	2500.0 [1]
	6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione	IC50	2500.0 [1]
	7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	IC50	69.0 [1]
	4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile	IC50	2.4 [1]
	6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile	IC50	9.0 [1]
	2-Bromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione	IC50	539.0 [1]
	4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile	IC50	95.0 [1]
	4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile	IC50	10000.0 [1]
	(+/-)-Hymenin	IC50	1288.0 [1]
	N-(4-(Benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide	IC50	9000.0 [1]
	4-(4-Phenoxyanilino)-6-methoxy-7-(2-morpholinoethoxy)-3-quinolinecarbonitrile	IC50	8.0 [1]
	2-Chloro-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-N-(2-pyridin-2-ylethyl)benzamide	IC50	20600.0 [1]
	N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-4-phenyl-N-(2-pyridin-2-ylethyl)pentanamide	IC50	11200.0 [1]
	6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile	IC50	18.0 [1]
	4-(4-Phenoxyanilino)-5-methoxy-3-quinolinecarbonitrile	IC50	98.0 [1]
	4-(4-Phenoxyanilino)-6,7,8-trimethoxy-3-quinolinecarbonitrile	IC50	10000.0 [1]
	4-(4-Phenoxyanilino)-8-methoxy-3-quinolinecarbonitrile	IC50	10000.0 [1]
	4-(4-Phenoxyanilino)-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile	IC50	28.0 [1]
	4-(4-Phenoxyanilino)-5,8-dimethoxy-3-quinolinecarbonitrile	IC50	10000.0 [1]
	4-(4-Phenoxyanilino)-5,7-dimethoxy-3-quinolinecarbonitrile	IC50	60.0 [1]
	4-(4-Phenoxyanilino)-3-quinolinecarbonitrile	IC50	125.0 [1]
	4-(4-Phenoxyanilino)-7-methoxy-3-quinolinecarbonitrile	IC50	90.0 [1]
	N-[(3-Hydroxy-4-phenylmethoxyphenyl)methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamide	IC50	19400.0 [1]
	N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-2-phenyl-N-(2-pyridin-2-ylethyl)cyclopropane-1-carboxamide	IC50	10500.0 [1]
	N-[[3-(2-Hydroxyethoxy)-4-phenylmethoxyphenyl]methyl]-5-phenyl-N-(2-pyridin-2-ylethyl)pentanamide	IC50	14200.0 [1]
	N-[(2-Chlorophenyl)methyl]-3-methoxy-4-phenylmethoxy-N-(2-pyridin-2-ylethyl)benzamide	IC50	16200.0 [1]
	N-[(2-Chlorophenyl)methyl]-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-2-pyridin-2-ylacetamide	IC50	25300.0 [1]
	N-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-N-[2-(6-oxo-1H-pyridin-2-yl)ethyl]-5-phenylpentanamide	IC50	12300.0 [1]
	Thieno[3,2-b]-pyridine-6-carbonitrile 12	IC50	1600.0 [1]
	4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide	IC50	4.6 [1]
	[2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] hydrogen sulfate	IC50	18.0 [1]
	4-[8-[2-Chloro-4-(4-methyl-3-oxopyrazin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide	IC50	4.5 [1]
	1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanone	IC50	53.0 [1]
	1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-methoxyethanone	IC50	9.0 [1]
	2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile	IC50	22.0 [1]
	1-[4-[7-Fluoro-2-methyl-8-[2-methyl-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	80.0 [1]
	1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	5.7 [1]
	4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-sulfonamide	IC50	213.0 [1]
	8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methyl-1-(1-methylsulfonylpiperidin-4-yl)imidazo[4,5-c]quinoline	IC50	40.0 [1]
	6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)-4-methylpiperidin-4-yl]imidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-one	IC50	59.0 [1]
	2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetamide	IC50	515.0 [1]
	2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanol	IC50	93.0 [1]
	1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	39.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone	IC50	28.0 [1]
	4-[7-Fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide	IC50	13.0 [1]
	1-[(3S,4S)-3-Fluoro-4-[7-fluoro-2-methyl-8-(2-methyl-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	2.6 [1]
	8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-[1-(2-methoxyethyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinoline	IC50	726.0 [1]
	[2-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-oxoethyl] acetate	IC50	232.0 [1]
	4-[3-Chloro-4-[1-[1-(cyanomethyl)piperidin-4-yl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-6-methylpyrimidine-2-carbonitrile	IC50	18.0 [1]
	2-[4-[7-Fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]ethanol	IC50	333.0 [1]
	2-Amino-1-[4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone	IC50	455.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	7.1 [1]
	2-Amino-1-[4-[8-[2-chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone	IC50	186.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-methoxyethanone	IC50	85.0 [1]
	4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide	IC50	3.6 [1]
	(2S)-1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one	IC50	19.0 [1]
	1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one	IC50	19.0 [1]
	1-[(3S,4S)-4-[8-[2-Chloro-4-[4-(trifluoromethyl)pyrimidin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone	IC50	1.0 [1]
	1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]ethanone	IC50	25.0 [1]
	4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N-(2,2,2-trifluoroethyl)piperidine-1-carboxamide	IC50	191.0 [1]
	4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-N,N-dimethylpiperidine-1-carboxamide	IC50	2350.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-one	IC50	73.0 [1]
	2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-1-ol	IC50	59.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoroethanone	IC50	40.0 [1]
	1-[4-[7-Fluoro-8-[2-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone	IC50	47.0 [1]
	1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-fluoroethanone	IC50	11.0 [1]
	4-[8-[2-Chloro-4-(1-methyl-2-oxopyridin-3-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide	IC50	3.8 [1]
	3-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-one	IC50	8.5 [1]
	4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide	IC50	3.0 [1]
	1-[4-[8-[2-Chloro-4-(4-methoxy-6-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone	IC50	10.0 [1]
	8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-1-(3-fluorooxan-4-yl)-2-methylimidazo[4,5-c]quinoline	IC50	280.0 [1]
	4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidine-1-carboxamide	IC50	11.0 [1]
	2-[4-[8-[2-Chloro-4-(1-methyl-6-oxopyrimidin-4-yl)oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile	IC50	113.0 [1]
	2-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanol	IC50	104.0 [1]
	1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-3-hydroxypropan-1-one	IC50	40.0 [1]
	(2S)-1-[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxypropan-1-one	IC50	7.3 [1]
	(2S)-1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one	IC50	88.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxypropan-1-one	IC50	62.0 [1]
	1-[4-[8-[2-Chloro-4-[6-(hydroxymethyl)pyridin-2-yl]oxyphenyl]-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	2.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]propan-2-ol	IC50	468.0 [1]
	2-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-methoxy-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]acetonitrile	IC50	3.7 [1]
	6-[3-Chloro-4-[7-fluoro-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-3-methylpyrimidin-4-one	IC50	45.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]ethanone	IC50	212.0 [1]
	3-[3-Chloro-4-[7-fluoro-1-[1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl]-2-methylimidazo[4,5-c]quinolin-8-yl]phenoxy]-1-methylpyridin-2-one	IC50	7.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-3-hydroxy-2-(hydroxymethyl)propan-1-one	IC50	1346.0 [1]
	4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidine-1-carboxamide	IC50	5.3 [1]
	1-[(3S,4S)-3-Fluoro-4-[7-fluoro-8-(2-fluoro-4-pyrimidin-2-yloxyphenyl)-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	32.0 [1]
	[(3S,4S)-4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-(oxetan-2-yl)methanone	IC50	11.0 [1]
	1-[4-[8-(2-Chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-fluoropropan-1-one	IC50	547.0 [1]
	1-[4-[8-[2-Chloro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-fluoroimidazo[4,5-c]quinolin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-one	IC50	28.0 [1]
	1-[4-[7-Fluoro-2-methyl-8-[4-(4-methylpyrimidin-2-yl)oxyphenyl]imidazo[4,5-c]quinolin-1-yl]piperidin-1-yl]-2-hydroxyethanone	IC50	179.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-and-dual-specificity-mitogen-activated-protein-kinase-kinase-1-raf-mek-inhibitors-ic50-ki.
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