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Serine/threonine-protein kinase RAF Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SorafenibIC506.2 [1]
SorafenibKi6.0 [1]
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-olIC509.0 [1]
VemurafenibIC5048.0 [1], 128.0 [2], 135.0 [3], 410.0 [4], 10000.0 [5]
3-(Dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamideIC5031.0 [1], 70.0 [2], 17000.0 [3]
StaurosporineIC50130.0 [1], 140.0 [2], 240.0 [3], 10000.0 [4]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC50330.0 [1], 370.0 [2], 2000.0 [3]
CID 46209401IC501.4 [1], 1.5 [2], 5.0 [3], 62.0 [4]
DoramapimodIC501000.0 [1], 1400.0 [2]
Methyl 5-tert-butyl-3-(3-phenylureido)thiophene-2-carboxylateIC5017000.0 [1]
Methyl 5-tert-butyl-3-(3-(4-hydroxyphenyl)ureido)thiophene-2-carboxylateIC5015000.0 [1], 18000.0 [2]
1-(5-Tert-butyl-1,2-oxazol-3-YL)-3-(4-pyridin-4-yloxyphenyl)ureaIC50230.0 [1]
5-Tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid methyl esterIC501700.0 [1]
1-(5-Tert-butyl-2-(dimethylcarbamoyl)thiophen-3-yl)-3-p-tolylureaIC5015000.0 [1]
1-(5-Tert-butylisoxazol-3-yl)-3-(4-phenoxyphenyl)ureaIC50540.0 [1], 1100.0 [2]
Methyl 5-tert-butyl-3-(3-(5-tert-butyl-1,3,4-thiadiazol-2-yl)ureido)thiophene-2-carboxylateIC5011000.0 [1]
4-(4-(3-(4-Bromo-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamideIC506.0 [1]
4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamideIC5075.0 [1], 1500.0 [2]
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamideIC506.5 [1]
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamideKi3.3 [1]
Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-IC5050.0 [1], 50000.0 [2]
Raf265(chir-265)IC5019.0 [1], 1200.0 [2]
t-TUCBIC5010000.0 [1]
(NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineKi1.72 [1]
LY-3009120IC504.3 [1], 42.0 [2]
3-[2-Phenyl-4-(Pyridin-4-Yl)-1h-Imidazol-5-Yl]phenolIC5023.0 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC50810.0 [1]
Methyl 3-(3-(4-aminophenyl)ureido)-5-tert-butylthiophene-2-carboxylateIC5018000.0 [1]
N-Methyl-4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzamideIC5010000.0 [1]
Methyl 5-isopropyl-3-(3-p-tolylureido)thiophene-2-carboxylateIC504000.0 [1]
5-Tert-Butyl-3-(3-p-tolyl-ureido)-1H-pyrrole-2-carboxylic acid methyl esterIC503000.0 [1]
1-(5-Tert-butyl-2-(methylcarbamoyl)thiophen-3-yl)-3-p-tolylureaIC504900.0 [1]
Methyl 5-tert-butyl-3-(3-p-tolylureido)furan-2-carboxylateIC503000.0 [1]
4-(4-(3-(2-Methoxy-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamideIC5053.0 [1]
4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(2-morpholin-4-ylethyl)pyridine-2-carboxamideIC5073.0 [1]
5-{4-[3-(2-Methoxy-5-trifluoromethyl-phenyl)-ureido]-phenoxy}-N-methyl-nicotinamideIC5061.0 [1]
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-ethylpicolinamideIC5026.0 [1]
Methyl 5-tert-butyl-3-(3-m-tolylureido)thiophene-2-carboxylateIC5020000.0 [1]
Methyl 5-tert-butyl-3-(3-(3,4-dichlorophenyl)ureido)-1H-pyrrole-2-carboxylateIC5012000.0 [1]
1-(4-Bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(dimethylcarbamoyl)pyridin-4-yloxy)phenyl)ureaIC50170.0 [1]
2-Phenyl-4-[3-(trifluoromethyl)phenyl]-5-(4-pyridyl)-1H-imidazoleIC502600.0 [1]
2-Phenyl-4-(3-chlorophenyl)-5-(4-pyridyl)-1H-imidazoleIC5090.0 [1]
4-(2,4-Diphenyl-1H-imidazol-5-yl)-N-methylpyrimidin-2-amineIC502100.0 [1]
2-Phenyl-4-(2-chlorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50610.0 [1]
2-Phenyl-4-(4-chlorophenyl)-5-(4-pyridyl)-1H-imidazoleIC5056.0 [1]
2-Phenyl-4-(4-methoxyphenyl)-5-(4-pyridyl)-1H-imidazoleIC50950.0 [1]
3-(3,5-Dibromo-4-hydroxybenzylidene)indolin-2-oneIC501300.0 [1]
1-(2-(Aminomethyl)-5-tert-butylthiophen-3-yl)-3-p-tolylureaIC5013000.0 [1]
[4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC50300.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC508.0 [1]
3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-oneIC5023.0 [1]
3-(3,5-Dichloro-4-hydroxybenzylidene)-5-phenylindolin-2-oneIC5032.0 [1]
3-(3,5-Dibromo-4-hydroxybenzylidene)-5-(cyclopropanecarbonyl)indolin-2-oneIC5025.0 [1]
Methyl 5-tert-butyl-3-(3-(1-isopropyl-1H-pyrazol-3-yl)ureido)thiophene-2-carboxylateIC5016000.0 [1]
Methyl 5-tert-butyl-3-(3-(3-chlorophenyl)ureido)thiophene-2-carboxylateIC5022000.0 [1]
Methyl 5-tert-butyl-3-(3-(3,4-dichlorophenyl)ureido)thiophene-2-carboxylateIC5020000.0 [1]
3-(4-(3-(5-Tert-butylisoxazol-3-yl)ureido)phenoxy)-N-methylbenzamideIC50120.0 [1]
5-(4-Hydroxy-2,6-dimethylstyryl)nicotinic acidIC50398.0 [1], 400.0 [2]
4-(4-(3-(5-Tert-butylisoxazol-3-yl)ureido)phenoxy)benzoic acidIC504400.0 [1], 6300.0 [2]
3-(2-Aminopropan-2-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamideIC502.5 [1], 60.0 [2]
N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamideIC502.87 [1], 107.1 [2]
3-[(3,5-Dichloro-4-hydroxyphenyl)methylidene]-5-(furan-2-carbonyl)-1H-indol-2-oneIC5046.0 [1]
6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5050000.0 [1]
[4,6-Dimethyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5078.0 [1]
5-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamideIC50175.0 [1]
4-[4-(1-Adamantylcarbamoylamino)cyclohexyl]oxy-N-methylbenzamideIC5010000.0 [1]
Methyl 5-tert-butyl-3-(3-(1-methyl-1H-pyrazol-3-yl)ureido)thiophene-2-carboxylateIC506700.0 [1]
Methyl 5-tert-butyl-3-(3-(5-methyl-1,3,4-thiadiazol-2-yl)ureido)thiophene-2-carboxylateIC501200.0 [1]
Methyl 5-tert-butyl-3-(3-(5-ethyl-1,3,4-thiadiazol-2-yl)ureido)thiophene-2-carboxylateIC502000.0 [1]
5-Bromomethyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid methyl esterIC506000.0 [1]
3-[3-(1-Ethyl-3-pyrrolyl)ureido]-5-tert-butylthiophene-2-carboxylic acid methyl esterIC507600.0 [1]
Methyl 5-tert-butyl-3-(3-(1-ethyl-1H-pyrazol-3-yl)ureido)thiophene-2-carboxylateIC508000.0 [1]
Methyl 5-tert-butyl-3-(3-(1-isopropyl-1H-pyrrol-3-yl)ureido)thiophene-2-carboxylateIC508100.0 [1]
4-[3-[3-[4-Chloro-3-(trifluoromethyl)anilino]-3-oxopropyl]phenoxy]-N-methylpyridine-2-carboxamideIC509.0 [1], 25000.0 [2]
4-[[7-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]-N-methylpyridine-2-carboxamideIC5028.0 [1], 2900.0 [2]
4-[[7-[[4-(Aminomethyl)-3-(trifluoromethyl)phenyl]carbamoyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]-N-methylpyridine-2-carboxamideIC5016.0 [1], 5000.0 [2]
4-[[7-[[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]carbamoyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]-N-methylpyridine-2-carboxamideIC5011.0 [1], 1400.0 [2]
3-[(Dimethylamino)methyl]-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamideIC502.2 [1], 50.0 [2]
4-[4-[3-[4-Chloro-3-(trifluoromethyl)anilino]-3-oxopropyl]phenoxy]-N-methylpyridine-2-carboxamideIC5010.0 [1], 25000.0 [2]
N-[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC506.2 [1], 150.0 [2]
(2S)-N-[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC504.5 [1], 130.0 [2]
(2R)-N-[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC506.0 [1], 780.0 [2]
(2S)-7-[2-(Cyclopropanecarbonylamino)pyridin-4-yl]oxy-N-[3-[(dimethylamino)methyl]-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC503.3 [1], 130.0 [2]
7-[2-(Cyclopropanecarbonylamino)pyridin-4-yl]oxy-N-[3-[(propan-2-ylamino)methyl]-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC504.6 [1], 190.0 [2]
(2S)-7-(2-Acetamidopyridin-4-yl)oxy-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC506.0 [1], 150.0 [2]
trans-4-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-benzoic acidIC504300.0 [1]
N-Methyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxypyridine-2-carboxamideIC5010000.0 [1]
4-[4-(1-Adamantylcarbamoylamino)phenoxy]-N-methylpyridine-2-carboxamideIC501000.0 [1], 10000.0 [2]
N-Methyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamideIC5030.0 [1]
N-[4-Methyl-3-(6-morpholin-4-ylpyrimidin-4-yl)phenyl]-3-(trifluoromethyl)benzamideIC500.14 [1]
N-[4-Methyl-3-(2-morpholin-4-yl-6-prop-1-en-2-ylpyrimidin-4-yl)phenyl]-3-(trifluoromethyl)benzamideIC500.09 [1], 0.14 [2]
N-[4-Methyl-3-(4-morpholin-4-yl-6-prop-1-en-2-ylpyrimidin-2-yl)phenyl]-3-(trifluoromethyl)benzamideIC500.38 [1], 0.39 [2]
N-[4-Methyl-3-(4-morpholin-4-yl-6-propan-2-ylpyrimidin-2-yl)phenyl]-3-(trifluoromethyl)benzamideIC500.64 [1], 0.71 [2]
N-[4-Methyl-3-(2-morpholin-4-yl-6-propan-2-ylpyrimidin-4-yl)phenyl]-3-(trifluoromethyl)benzamideIC501.02 [1], 1.39 [2]
4-Methyl-3-(2-morpholin-4-ylpyridin-4-yl)-N-[3-(trifluoromethyl)phenyl]benzamideIC500.44 [1], 0.51 [2]
2-(2-Cyanopropan-2-yl)-N-[4-methyl-3-(6-morpholin-4-ylpyrimidin-4-yl)phenyl]pyridine-4-carboxamideIC501.42 [1], 2.95 [2]
3-[6-(1,1-Dioxo-1,4-thiazinan-4-yl)-2-morpholin-4-ylpyrimidin-4-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamideIC501.11 [1], 1.18 [2]
N-[3-[2-(1,1-Dioxo-1,4-thiazinan-4-yl)-6-morpholin-4-ylpyrimidin-4-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamideIC500.9 [1], 0.95 [2]
N-[3-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamideIC500.1 [1], 0.12 [2]
3-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamideIC500.54 [1], 0.58 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase RAF Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 7 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 7). Quest Database™ Serine/threonine-protein kinase RAF Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-raf-inhibitors-ic50-ki.
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