Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(4S,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione	IC50	62.0 [1], 1213.0 [2]
	N-[4-[(6-Chloro-[1,3]dioxolo[4,5-B]pyridin-7-Yl)amino]-2-Pyridyl]cyclopropanecarboxamide	IC50	1.1 [1], 4.0 [2], 45.0 [3]
	4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline	IC50	11.13 [1], 13.3 [2]
	N-[4-(Pyridin-4-ylamino)pyridin-2-yl]cyclopropanecarboxamide	IC50	1000.0 [1], 3800.0 [2]
	N-[4-[(6-Chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)-methylamino]pyridin-2-yl]cyclopropanecarboxamide	IC50	26.0 [1], 320.0 [2]
	N-[4-(1,3-Benzodioxol-4-ylamino)pyridin-2-yl]cyclopropanecarboxamide	IC50	120.0 [1], 2300.0 [2]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]acetamide	IC50	48.0 [1], 3600.0 [2]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclopropanecarboxamide	IC50	17.0 [1], 240.0 [2]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]propanamide	IC50	40.0 [1], 980.0 [2]
	[4-[4-Amino-7-[(3R)-piperidin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	1.9 [1], 3.0 [2]
	4-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-ol	IC50	2.0 [1], 6.7 [2]
	[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanol	IC50	4.4 [1], 21.0 [2]
	4-[4-Amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-ol	IC50	124.0 [1], 170.0 [2]
	Staurosporine	IC50	850.0 [1]
	Staurosporine HCl	IC50	1.36 [1]
	Dorsomorphin	IC50	106.3 [1]
	Vactosertib	IC50	10000.0 [1]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	125.0 [1]
	5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	14.4 [1]
	1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine	IC50	27.0 [1]
	5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	46.0 [1]
	4-[6-(4-Propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	27.0 [1]
	4-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline	IC50	26.5 [1]
	4-Amino-N-[4-[(3-fluorophenyl)carbamoylamino]phenyl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide	IC50	10000.0 [1]
	CID 60182364	IC50	5.0 [1]
	CID 60182389	IC50	5.0 [1]
	4-(4-(3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholine	IC50	42.1 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	(4S,8R,9S,10S)-8,9,10,18-Tetrahydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-one	IC50	1785.0 [1]
	(4S,9R,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-8-methylidene-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-one	IC50	1256.0 [1]
	2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol	IC50	100000.0 [1]
	Alk2-IN-2	IC50	51.0 [1]
	(4S,8S,9S,10S)-8,9,10,18-Tetrahydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-2-one	IC50	770.0 [1]
	6-(4-Methoxyphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine	IC50	52.4 [1]
	6-(4-Piperazin-1-ylphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine	IC50	55.0 [1]
	3-Methyl-6-[2-(6-methylpyridin-2-yl)pyrazol-3-yl]quinazolin-4-one	IC50	5000.0 [1]
	[4-(4-Amino-7-morpholin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl]methanol	IC50	25.0 [1]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]benzamide	IC50	340.0 [1]
	N-(4-Anilinopyridin-2-yl)cyclopropanecarboxamide	IC50	2300.0 [1]
	N-[4-(2-Chloroanilino)pyridin-2-yl]cyclopropanecarboxamide	IC50	4600.0 [1]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]-2-methylpropanamide	IC50	800.0 [1]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclobutanecarboxamide	IC50	230.0 [1]
	N-[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyridin-2-yl]cyclopentanecarboxamide	IC50	940.0 [1]
	6-(1-Methylpiperidin-4-yl)-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	9.81 [1]
	2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-(1-methylpiperidin-4-yl)-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	15.11 [1]
	2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-[2-(dimethylamino)ethyl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	38.86 [1]
	2-[4-[1-(2,5-Difluorophenyl)propan-2-ylamino]-2-oxo-1H-pyridin-3-yl]-6-[2-(dimethylamino)ethyl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	9.16 [1]
	8-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	231.3 [1]
	8-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	23.7 [1]
	4-Methyl-6-(1-methylpiperidin-4-yl)-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-1,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	14.59 [1]
	6-[2-(Dimethylamino)ethyl]-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	4.7 [1]
	2-[2-Oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	47.3 [1]
	6-(6-Fluoropyridin-3-yl)-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	10000.0 [1]
	5-Methoxy-2-[2-oxo-4-[1-(2,3,5,6-tetrafluorophenyl)propan-2-ylamino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	174.4 [1]
	5-Hydroxy-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-6-pyridin-3-yl-3,5-dihydropyrrolo[3,4-f]benzimidazol-7-one	IC50	15.18 [1]
	6-[2-(Dimethylamino)ethyl]-2-[2-oxo-4-[[(2S)-1-(2,3,5,6-tetrafluorophenyl)propan-2-yl]amino]-1H-pyridin-3-yl]-3H-pyrrolo[3,4-f]benzimidazole-5,7-dione	IC50	14.03 [1]
	[4-[4-Amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	4.1 [1]
	3-[4-Amino-5-[4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]propan-1-ol	IC50	4.0 [1]
	1-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]ethanol	IC50	3.8 [1]
	1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperidin-3-ol	IC50	70.0 [1]
	[4-(4-Amino-7-propylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]methanol	IC50	2.0 [1]
	[4-[4-Amino-7-(2-methyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanol	IC50	4.0 [1]
	1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperidin-4-ol	IC50	65.0 [1]
	[4-[4-Amino-7-(2-methyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	5.3 [1]
	3-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]piperidin-3-ol	IC50	5.7 [1]
	[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methylphenyl]methanol	IC50	4.0 [1]
	[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methoxyphenyl]methanol	IC50	2.0 [1]
	[4-(4-Amino-7-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanol	IC50	1.9 [1]
	4-[4-Amino-5-[4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]butan-1-ol	IC50	1.0 [1]
	[4-(4-Amino-7-pyrrolidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-ethyl-6-fluorophenyl]methanol	IC50	3.0 [1]
	[4-[4-Amino-7-(piperazin-1-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanol	IC50	80.0 [1]
	[4-(4-Amino-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]methanol	IC50	8.0 [1]
	[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluoro-6-methylphenyl]methanol	IC50	4.0 [1]
	1-[[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]pyrrolidin-3-ol	IC50	30.0 [1]
	[4-(4-Amino-7-propylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2,6-difluorophenyl]methanol	IC50	2.8 [1]
	[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanol	IC50	1.3 [1]
	[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-(oxan-4-yl)methanol	IC50	40.0 [1]
	[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	30.0 [1]
	[4-[4-Amino-7-(2-amino-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanol	IC50	2.0 [1]
	4-[4-Amino-5-[3-fluoro-4-(hydroxymethyl)-5-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-ol	IC50	1.0 [1]
	[4-Amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanol	IC50	5.7 [1]
	[4-Amino-5-[4-(hydroxymethyl)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-cyclopropylmethanol	IC50	1.2 [1]
	[4-(4-Amino-7-piperidin-3-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-ethyl-6-fluorophenyl]methanol	IC50	4.0 [1]
	[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanol	IC50	19.0 [1]
	[5-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]pyridin-2-yl]methanol	IC50	140.0 [1]
	[4-[4-Amino-7-(2-ethyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	2.6 [1]
	[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-methylphenyl]methanol	IC50	30.0 [1]
	[4-[4-Amino-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-chlorophenyl]methanol	IC50	17.0 [1]
	1-[4-Amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclohexan-1-ol	IC50	15.0 [1]
	[4-[4-Amino-7-[(3S)-piperidin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2,6-difluorophenyl]methanol	IC50	5.9 [1]
	[4-[4-Amino-7-(2-ethyl-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl]methanol	IC50	60.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 91 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-receptor-r3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase receptor R3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-receptor-r3-inhibitors-ic50-ki.
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