Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole	IC50	200.0 [1]
	CID 67469084	IC50	5.0 [1], 18.0 [2], 237.0 [3], 10000.0 [4]
	4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol	IC50	3.0 [1], 20.0 [2], 10000.0 [3]
	1-[3,5-Difluoro-4-[2-(methylamino)pyridin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	320.0 [1], 790.0 [2], 2000.0 [3]
	1-(5-Tert-butyl-1,2-oxazol-3-YL)-3-(4-pyridin-4-yloxyphenyl)urea	IC50	63.0 [1], 320.0 [2]
	2-[2-Fluoro-4-[[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyphenyl]carbamoylamino]phenyl]sulfanylacetic acid	IC50	2260.0 [1], 4870.0 [2]
	N-[3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenyl]acetamide	IC50	21.0 [1], 32.0 [2]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)pyridin-2-amine	IC50	29.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amine	IC50	6.0 [1], 9.0 [2]
	6-Tert-butylsulfonyl-3-(1H-indazol-5-yl)-7-methoxyimidazo[1,2-a]pyridine	IC50	20.0 [1], 130.0 [2]
	N-[4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)pyridin-2-yl]acetamide	IC50	40.0 [1], 60.0 [2]
	4-(7-Ethoxy-6-propan-2-ylsulfonylimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine	IC50	3.0 [1], 30.0 [2]
	N-[3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-5-chlorophenyl]acetamide	IC50	2.0 [1], 9.0 [2]
	6-Tert-butylsulfonyl-N-(5-methyl-1H-pyrazol-3-yl)quinolin-4-amine	IC50	126.0 [1], 742.0 [2]
	6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(trifluoromethoxy)quinolin-4-amine	IC50	6.3 [1], 446.0 [2]
	6-Tert-butylsulfonyl-N-(1H-pyrazol-5-yl)quinolin-4-amine	IC50	794.0 [1], 3226.0 [2]
	6-Tert-butylsulfonyl-N-(4,5,6,7-tetrahydro-1H-indazol-3-yl)quinolin-4-amine	IC50	4719.0 [1], 5012.0 [2]
	2-(2-(4-Chlorophenyl)-1h-Imidazol-5-Yl)-N,1-Bis(2-Methoxyethyl)-1h-Benzo[d]imidazole-5-Carboxamide	IC50	12.0 [1], 500.0 [2]
	6-Tert-butylsulfonyl-N-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)quinolin-4-amine	IC50	79.0 [1], 1380.0 [2]
	6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)quinolin-4-amine	IC50	6.3 [1], 100.0 [2]
	RIP2 Kinase Inhibitor 3	IC50	1.3 [1], 11.0 [2]
	6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-ethoxyquinolin-4-amine	IC50	1.6 [1], 41.0 [2]
	6-Tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-ethylquinolin-4-amine	IC50	2.5 [1], 154.0 [2]
	2-[6-Tert-butylsulfonyl-4-[(4,5-dimethyl-1H-pyrazol-3-yl)amino]quinolin-7-yl]oxyethanol	IC50	2.5 [1], 15.0 [2]
	RIP2 kinase inhibitor 2	IC50	2.5 [1], 5.0 [2]
	2,6-Difluoro-N-[3-[5-[2-(3-methylsulfonylanilino)pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide	IC50	6.3 [1], 7.9 [2]
	Gefitinib	IC50	3.8 [1]
	Sorafenib	IC50	3600.0 [1]
	Dasatinib	IC50	109.0 [1]
	1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	19.0 [1]
	Ponatinib	IC50	6.7 [1]
	Doramapimod	IC50	10000.0 [1]
	Galunisertib	IC50	44.0 [1]
	2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine	IC50	685.0 [1]
	3-(Dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide	IC50	100000.0 [1]
	1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	26.0 [1]
	Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-	IC50	111.0 [1]
	1-Tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	130.0 [1]
	Vactosertib	IC50	54.0 [1]
	Src Kinase Inhibitor I	IC50	26.0 [1]
	1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	120.0 [1]
	CID 59604787	IC50	10000.0 [1]
	Ripk-IN-4	IC50	3.0 [1]
	4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine	IC50	41.0 [1]
	4-Methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}phenol	IC50	10.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	N-(2-Chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide	IC50	1500.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	37000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	4-Methyl-3-(quinolin-4-ylamino)phenol	IC50	630.0 [1]
	3-[(6-Methoxyquinolin-4-yl)amino]-4-methylphenol	IC50	250.0 [1]
	4-[6-Tert-butylsulfonyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amine	IC50	8.0 [1]
	5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine	IC50	403.1 [1]
	4-[6-Tert-butylsulfonyl-7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amine	IC50	5.0 [1]
	2-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamide	IC50	10000.0 [1]
	6-Tert-butylsulfonyl-3-(3-chloro-5-methoxyphenyl)-7-methoxyimidazo[1,2-a]pyridine	IC50	45.0 [1]
	3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenol	IC50	35.0 [1]
	6-Tert-butylsulfonyl-3-(1H-indazol-6-yl)-7-methoxyimidazo[1,2-a]pyridine	IC50	200.0 [1]
	6-Tert-butylsulfonyl-7-methoxy-3-(2-methoxyphenyl)imidazo[1,2-a]pyridine	IC50	460.0 [1]
	(2-Methylphenyl) 6-tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridine-3-carboxylate	IC50	38.0 [1]
	6-Tert-butylsulfonyl-3-(2-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridine	IC50	10000.0 [1]
	4-(6-Tert-butylsulfonyl-7-cyclopropyloxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amine	IC50	58.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-methoxyphenol	IC50	11.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamide	IC50	160.0 [1]
	6-Tert-butylsulfonyl-7-methoxy-3-(4-methoxyphenyl)imidazo[1,2-a]pyridine	IC50	130.0 [1]
	4-(6-Tert-butylsulfonyl-7-propan-2-yloxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amine	IC50	7.0 [1]
	6-Tert-butylsulfonyl-3-(3-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridine	IC50	90.0 [1]
	3-(3H-Benzimidazol-5-yl)-6-tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridine	IC50	120.0 [1]
	4-(6-Tert-butylsulfonyl-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-chloropyridin-2-amine	IC50	5.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)phenol	IC50	16.0 [1]
	3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-5-chlorophenol	IC50	9.0 [1]
	3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzamide	IC50	430.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-chlorophenol	IC50	5.0 [1]
	6-Tert-butylsulfonyl-7-methoxy-N-(2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide	IC50	24.0 [1]
	4-[6-Tert-butylsulfonyl-7-(2,2,2-trifluoroethoxy)imidazo[1,2-a]pyridin-3-yl]-6-chloropyridin-2-amine	IC50	7.0 [1]
	6-Tert-butylsulfonyl-7-methoxy-3-(3-methoxyphenyl)imidazo[1,2-a]pyridine	IC50	40.0 [1]
	4-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)-2-chlorobenzamide	IC50	70.0 [1]
	6-Tert-butylsulfonyl-3-(4-chlorophenyl)-7-methoxyimidazo[1,2-a]pyridine	IC50	520.0 [1]
	2-[2-Fluoro-4-[(2-fluorophenyl)carbamoylamino]phenyl]sulfanylacetic acid	IC50	13200.0 [1]
	3-(6-Tert-butylsulfonyl-7-methoxyimidazo[1,2-a]pyridin-3-yl)benzonitrile	IC50	180.0 [1]
	N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide	IC50	50978.0 [1]
	4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium	IC50	10000.0 [1]
	N-(6-Methylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine	IC50	6.3 [1]
	N-(2H-Benzotriazol-5-yl)-6-methylsulfonylquinolin-4-amine	IC50	50.0 [1]
	4-(5-Hydroxy-2-methylanilino)-N-(oxan-4-ylmethyl)quinoline-6-carboxamide	IC50	20.0 [1]
	N-(5-Fluoro-1H-indazol-3-yl)-6-propan-2-ylsulfonylquinolin-4-amine	IC50	10.0 [1]
	N-(5-Fluoro-1H-indazol-3-yl)-6-methylsulfonylquinolin-4-amine	IC50	50.0 [1]
	1-Benzyl-3-[4-(3-bromoanilino)quinazolin-6-yl]thiourea	IC50	10000.0 [1]
	4-Methyl-3-[[6-(trifluoromethyl)quinolin-4-yl]amino]phenol	IC50	8.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 89 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-ripk2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase RIPK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-ripk2-inhibitors-ic50-ki.
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