Serine/threonine-protein kinase Sgk1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sgk1-IN-1	IC50	1.0 [1]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide	IC50	3.0 [1]
	Sgk1-IN-2	IC50	5.0 [1], 25.0 [2], 630.0 [3]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluorophenyl]-5-chloro-2-fluorobenzenesulfonamide	IC50	2.0 [1], 50.0 [2], 2100.0 [3]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluorophenyl]-2,5-dichlorobenzenesulfonamide	IC50	2.0 [1], 13.0 [2], 2600.0 [3]
	5-Chloro-2-fluoro-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	4.0 [1], 88.0 [2], 1500.0 [3]
	2-Cyano-5-methyl-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	3.0 [1], 580.0 [2], 2900.0 [3]
	2-Fluoro-5-methyl-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	2.0 [1], 29.0 [2], 2400.0 [3]
	2-Chloro-5-methoxy-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	2.0 [1], 34.0 [2], 1500.0 [3]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methoxybenzenesulfonamide	IC50	2.0 [1], 40.0 [2]
	2,5-Dichloro-N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	439.0 [1], 4550.0 [2]
	2,5-Dichloro-N-[2-fluoro-4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	496.0 [1], 3330.0 [2]
	2,3-Dichloro-N-[2-fluoro-4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	419.0 [1], 5730.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-hydrazinylbenzenesulfonamide	IC50	196.0 [1], 639.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluorophenyl]-2,3-dichlorobenzenesulfonamide	IC50	3.0 [1], 182.0 [2]
	2,5-Dichloro-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	2.0 [1], 11.0 [2]
	2,3-Dichloro-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	13.0 [1], 605.0 [2]
	5-Chloro-2-cyano-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	3.0 [1], 150.0 [2]
	5-Chloro-2-fluoro-N-[4-[4-(4-hydroxycyclohexyl)oxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide	IC50	1.2 [1], 1.5 [2], 120.0 [3], 670.0 [4]
	2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	IC50	13.0 [1], 580.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-chlorobenzenesulfonamide	IC50	14.0 [1], 910.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-chloro-3-fluorobenzenesulfonamide	IC50	21.0 [1], 1260.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-fluorobenzenesulfonamide	IC50	22.0 [1], 1490.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-difluorobenzenesulfonamide	IC50	15.0 [1], 730.0 [2]
	N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine	IC50	2700.0 [1]
	4-(5-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	IC50	40.0 [1], 1300.0 [2]
	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	IC50	1320.0 [1]
	[4-(5-Naphthalen-2-Yl-1h-Pyrrolo[2,3-B]pyridin-3-Yl)phenyl]acetic Acid	IC50	63.0 [1], 880.0 [2]
	2-Isobutyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	IC50	5.0 [1], 580.0 [2]
	2-Ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	IC50	20.0 [1], 710.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide	IC50	2.0 [1], 261.0 [2]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1], 5000.0 [2]
	5-Chloro-2-cyano-N-[4-[4-(4-hydroxycyclohexyl)oxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide	IC50	1.5 [1], 110.0 [2]
	N-[4-[4-(3-Aminopropoxy)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-2,5-dichlorobenzenesulfonamide	IC50	1.2 [1], 280.0 [2]
	2-Fluoro-N-[4-[4-(4-hydroxycyclohexyl)oxy-3-methyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-5-methoxybenzenesulfonamide	IC50	1.5 [1], 170.0 [2]
	2-Fluoro-N-[4-(4-methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-5-methylbenzenesulfonamide	IC50	1.5 [1], 50.0 [2]
	N-[4-(4-Cyclopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-2-fluoro-5-methylbenzenesulfonamide	IC50	6.5 [1], 150.0 [2]
	2-Fluoro-5-methyl-N-[4-[4-(morpholin-2-ylmethoxy)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide	IC50	6.2 [1], 10.0 [2]
	N-[4-[3-Amino-4-(2-methylpropoxy)-2H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-2,5-dichlorobenzenesulfonamide	IC50	130.0 [1], 220.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide	IC50	19.0 [1], 390.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-1-(2,5-difluorophenyl)methanesulfonamide	IC50	28.0 [1], 9830.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-bromothiophene-2-sulfonamide	IC50	3.0 [1], 718.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-sulfonamide	IC50	14.0 [1], 518.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]furan-2-sulfonamide	IC50	19.0 [1], 6840.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2,5-dichlorothiophene-3-sulfonamide	IC50	1.0 [1], 63.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]benzenesulfonamide	IC50	124.0 [1], 9720.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2-chlorobenzenesulfonamide	IC50	1.0 [1], 396.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide	IC50	1.0 [1], 14.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-3-chloro-2-cyanobenzenesulfonamide	IC50	6.0 [1], 199.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-cyano-2-methylbenzenesulfonamide	IC50	46.0 [1], 1970.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-chloro-2-cyanobenzenesulfonamide	IC50	2.0 [1], 17.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2-fluoro-5-(trifluoromethyl)benzenesulfonamide	IC50	1.0 [1], 129.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2-fluorobenzenesulfonamide	IC50	1.0 [1], 1110.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2,3-difluorobenzenesulfonamide	IC50	9.0 [1], 2580.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2,5-difluorobenzenesulfonamide	IC50	1.0 [1], 186.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-2-chloro-5-methoxybenzenesulfonamide	IC50	1.0 [1], 51.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-bromo-2-chlorobenzenesulfonamide	IC50	1.0 [1], 4.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-bromo-2-fluorobenzenesulfonamide	IC50	5.0 [1], 6.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-3-chloro-2-fluorobenzenesulfonamide	IC50	5.0 [1], 169.0 [2]
	N-[4-(3-Amino-1H-indazol-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide	IC50	1.0 [1], 7.0 [2]
	2,5-Difluoro-N-[4-(3-methyl-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide	IC50	29.0 [1], 1340.0 [2]
	2-Methyl-2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)propanoic acid	IC50	63.0 [1], 870.0 [2]
	2-Methyl-2-(4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)propanoic acid	IC50	50.0 [1], 1460.0 [2]
	2-(4-(5-(3-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)-2-methylpropanoic acid	IC50	40.0 [1], 2000.0 [2]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	10000.0 [1]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-fluoro-5-methoxybenzenesulfonamide	IC50	2.0 [1], 4.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide	IC50	3.0 [1], 61.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-chloro-5-methoxybenzenesulfonamide	IC50	2.0 [1], 34.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-fluoro-5-methylbenzenesulfonamide	IC50	2.0 [1], 39.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-cyanobenzenesulfonamide	IC50	10.0 [1], 293.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorothiophene-3-sulfonamide	IC50	4.0 [1], 183.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]naphthalene-1-sulfonamide	IC50	16.0 [1], 760.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2,4-difluorobenzenesulfonamide	IC50	2.0 [1], 41.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-chloro-4-(trifluoromethyl)benzenesulfonamide	IC50	407.0 [1], 18900.0 [2]
	N-[4-(3-Amino-4-cyclopropyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-2-cyano-5-methoxybenzenesulfonamide	IC50	1.5 [1], 61.0 [2]
	2,5-Dichloro-N-[4-(3-methyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]benzenesulfonamide	IC50	1.2 [1], 830.0 [2]
	N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-cyano-2-fluorobenzenesulfonamide	IC50	47.0 [1]
	5-Chloro-N-[4-[3-[(5-chloro-2,4-difluorophenyl)sulfonylamino]-1H-pyrazolo[3,4-b]pyrazin-6-yl]phenyl]-2,4-difluorobenzenesulfonamide	IC50	413.0 [1]
	Staurosporine	IC50	14.0 [1]
	Tofacitinib	IC50	10000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine	IC50	3570.0 [1]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	201.0 [1]
	CID 6918852	Ki	5000.0 [1]
	JNK Inhibitor V	IC50	10000.0 [1]
	JNK Inhibitor VIII	Ki	9400.0 [1]
	CID 11634725	Ki	10000.0 [1]
	2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amine	IC50	250000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	Merck-22-6	IC50	50000.0 [1]
	4-(Pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one	IC50	10000.0 [1]
	(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one	IC50	50000.0 [1]
	N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-Dicarboxamide	IC50	33000.0 [1]
	10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine	IC50	10000.0 [1]
	3-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxylic acid	IC50	50000.0 [1]
	(2S)-1-N-(5-Isoquinolin-6-yl-1,3,4-thiadiazol-2-yl)-3-[4-(trifluoromethyl)phenyl]propane-1,2-diamine	IC50	2200.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	9400.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	9400.0 [1]
	2-[4-[[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-3-phenylquinoxaline-6-carboxylic acid	IC50	50000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	8176.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase Sgk1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-sgk1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase Sgk1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-sgk1-inhibitors-ic50-ki.
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