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Serine/threonine-protein kinase TBK1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamideIC508.0 [1], 10.0 [2]
N-[3-[[6-Bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamideIC504.0 [1], 6.0 [2]
IKK-3 InhibitorIC5072.0 [1], 93.0 [2]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1], 10000.0 [2]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1], 10000.0 [2]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1], 10000.0 [2]
N-[3-[[6-Carbamothioyl-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamideIC5046.0 [1], 165.0 [2]
N-(3-Hydroxy-2,2-dimethylpropyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamideIC50100.0 [1], 136.0 [2]
5-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acidIC50256.0 [1], 30000.0 [2]
5-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-3-carboxylic acidIC50129.0 [1], 30000.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(3-methylbutyl)thiophene-2-carboxamideIC5078.0 [1], 143.0 [2]
N-(2-Methoxyethyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamideIC5098.0 [1], 170.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylpropyl)thiophene-2-carboxamideIC5037.0 [1], 77.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamideIC5030.0 [1], 268.0 [2]
5-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]furan-3-carboxylic acidIC501050.0 [1], 30000.0 [2]
2-[7-[3-(Cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-1,3-thiazole-4-carboxylic acidIC5036.0 [1], 2170.0 [2]
4-[7-[3-(Cyclopentanecarbonylamino)propoxy]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acidIC50460.0 [1], 3000.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylbutyl)thiophene-2-carboxamideIC5089.0 [1], 219.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acidIC5049.0 [1], 30000.0 [2]
2-[7-[3-(Cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-1,3-thiazole-4-carboxamideIC507.0 [1], 9.0 [2]
1-[4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophen-2-yl]ethanoneIC50650.0 [1], 1780.0 [2]
4-[2-(4-Methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-methylthiophene-2-carboxamideIC50203.0 [1], 851.0 [2]
2-[7-[3-(Cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylpropyl)-1,3-thiazole-4-carboxamideIC50128.0 [1], 388.0 [2]
N-(2,2-Dimethylpropyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamideIC5030.0 [1], 84.0 [2]
2-Amino-N-(3-methylpyridin-4-yl)-5-[5-(morpholin-4-ylmethyl)thiophen-2-yl]pyridine-3-carboxamideIC50260.0 [1], 7000.0 [2]
2-Amino-5-(4-pyrazol-1-ylphenyl)-N-pyridin-4-ylpyridine-3-carboxamideIC50120.0 [1], 10000.0 [2]
2-Amino-5-(6-piperazin-1-ylpyridin-3-yl)-N-pyridin-4-ylpyridine-3-carboxamideIC50770.0 [1], 9800.0 [2]
2-Amino-5-(1-benzylpyrazol-4-yl)-N-(2-methylpyridin-4-yl)pyridine-3-carboxamideIC50330.0 [1], 8100.0 [2]
2-Amino-5-[5-(morpholin-4-ylmethyl)thiophen-2-yl]-N-pyridazin-4-ylpyridine-3-carboxamideIC50240.0 [1], 9300.0 [2]
2-Amino-5-[5-(piperidin-1-ylmethyl)thiophen-2-yl]-N-pyridin-4-ylpyridine-3-carboxamideIC50390.0 [1], 1100.0 [2]
2-Amino-N-(2-ethoxypyridin-4-yl)-5-[5-(morpholin-4-ylmethyl)thiophen-2-yl]pyridine-3-carboxamideIC50430.0 [1], 3000.0 [2]
2-Amino-5-(3-pyrazol-1-ylphenyl)-N-pyridin-4-ylpyridine-3-carboxamideIC50400.0 [1], 4500.0 [2]
2-Amino-N-(2-methylpyridin-4-yl)-5-[5-(morpholin-4-ylmethyl)thiophen-2-yl]pyridine-3-carboxamideIC5078.0 [1], 3100.0 [2]
2-Amino-5-[1-(2-methoxyethyl)pyrazol-4-yl]-N-pyridin-4-ylpyridine-3-carboxamideIC5067.0 [1], 7800.0 [2]
5-[2-[[1-(4-Hydroxycyclohexyl)pyrazol-4-yl]amino]pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrileIC503.0 [1], 8.0 [2]
BosutinibIC50471.0 [1]
AmlexanoxIC50851.14 [1]
DoramapimodIC5030000.0 [1]
SilmitasertibIC5035.0 [1]
CID 11634725Ki10000.0 [1]
CID 59604787IC5010000.0 [1]
N-[3-[[5-Cyclopropyl-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC506.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1525.0 [1]
N-[3-[[5-Bromo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamideIC506.0 [1]
5-Phenyl-3-[1-(propylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamideIC503162.28 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC501070.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
6-Chloro-N-methyl-2-[4-(2-morpholin-4-ylethoxy)phenyl]-1H-imidazo[4,5-b]pyridin-7-amineIC50383.0 [1]
5-Phenyl-3-(3-piperidinyl)-1H-indole-7-carboxamideIC503162.28 [1]
3-[5-Chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamideIC5010000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
3-[2-(4-Amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamideIC5010000.0 [1]
(2S,4R)-1-[(2S)-2-[[2-[3-[4-[3-[4-[[5-Bromo-4-[3-[cyclobutanecarbonyl(methyl)amino]propylamino]pyrimidin-2-yl]amino]phenoxy]propoxy]butoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamideIC501.3 [1]
2-Amino-7-(dimethylamino)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5095499.26 [1]
2-Amino-7-cyclopropyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC502300.0 [1]
2-Amino-5-oxo-7-(thian-4-yl)chromeno[2,3-b]pyridine-3-carboxylic acidIC50489778.82 [1]
2-Amino-7-morpholin-4-yl-5-oxo-N-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridine-3-carboxamideIC50760.0 [1]
2-Amino-7-(2-methylpropyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC502818382.93 [1]
2-Amino-5-oxo-8-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC50302.0 [1]
2-Amino-5-oxo-7-(4-oxocyclohexyl)chromeno[2,3-b]pyridine-3-carboxylic acidIC50630957.34 [1]
2-Amino-5-oxo-8-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC502290.87 [1]
2-Amino-7-(cyclohexen-1-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC501700.0 [1]
2-Amino-7-cyclopentyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC501800.0 [1]
2-Amino-7-cyclobutyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC504600.0 [1]
5-Amino-9-oxo-12-propan-2-yl-2-oxa-4,13-diazatricyclo[8.4.0.03,8]tetradeca-1(14),3,5,7,10,12-hexaene-6-carboxylic acidIC5085113.8 [1]
5-Amino-9-oxo-12-prop-1-en-2-yl-2-oxa-4,13-diazatricyclo[8.4.0.03,8]tetradeca-1(14),3,5,7,10,12-hexaene-6-carboxylic acidIC50524807.46 [1]
2-Amino-7-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50750.0 [1]
7-(1-Acetylpiperidin-4-yl)-2-amino-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5016982.44 [1]
2-Amino-7-(3-methylbutyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5010715193.05 [1]
2-Amino-7-(3,6-dihydro-2H-pyran-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50257039.58 [1]
2-Amino-7-(1,1-dioxothian-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50830.0 [1]
2-Amino-8-fluoro-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC50398.11 [1]
2-Amino-7-(1-formylpiperidin-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50490.0 [1]
2-Amino-7-cyclohexyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5019054607.18 [1]
2-Amino-7-(oxan-4-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50750.0 [1]
2-Amino-7-(3-methylbut-1-ynyl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC5050118723.36 [1]
2-Amino-8-fluoro-5-oxo-7-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC50794.33 [1]
2-Amino-7-(1,4-dioxaspiro[4.5]decan-8-yl)-5-oxochromeno[2,3-b]pyridine-3-carboxylic acidIC50440.0 [1]
2-Amino-7-morpholin-4-yl-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50537.03 [1]
2-Amino-7-cyclohexyl-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC501905.46 [1]
2-Amino-5-oxo-7-prop-1-en-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC501348.96 [1]
4-[6-Bromo-7-(methylamino)-1H-imidazo[4,5-b]pyridin-2-yl]phenolIC50201.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC507610.0 [1]
2-Amino-7-(cyclohexen-1-yl)-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50489.78 [1]
2-Amino-5-oxo-6-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acidIC501096.48 [1]
2-Amino-7-(dimethylamino)-3-(2H-tetrazol-5-yl)chromeno[2,3-b]pyridin-5-oneIC50524.81 [1]
N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideIC504000.0 [1]
N-[3-[[5-Cyclopropyl-2-(3-fluoroanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC508.0 [1]
N-[3-[[5-Cyclopropyl-2-(2-fluoroanilino)pyrimidin-4-yl]amino]propyl]thiophene-2-carboxamideIC50820.0 [1]
N-[3-[[5-Cyclopropyl-2-[3-(1,3-oxazol-5-yl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5011.0 [1]
N-[3-[[5-Cyclopropyl-2-[3-(1,2,4-triazol-1-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC503.0 [1]
N-[3-[[5-Cyclopropyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC508.0 [1]
N-[3-[[5-Cyclopropyl-2-[[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC509.0 [1]
N-[3-[[5-Cyclopropyl-2-(pyrimidin-5-ylamino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC503200.0 [1]
N-[3-[[5-Cyclopropyl-2-[(1-propan-2-ylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC504.0 [1]
N-[3-[[5-Cyclopropyl-2-[[1-(oxan-4-yl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC502.0 [1]
N-[3-[[5-Cyclopropyl-2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5028.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serine/threonine-protein kinase TBK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-tbk1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Serine/threonine-protein kinase TBK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-tbk1-inhibitors-ic50-ki.
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