Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dione	IC50	97.0 [1], 97.72 [2]
	Wee1 Inhibitor	IC50	11.0 [1]
	4-(2,6-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	28.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	57.0 [1]
	Wee1 Inhibitor II	IC50	59.0 [1]
	9-Hydroxy-6-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	140.0 [1], 257.04 [2], 260.0 [3]
	4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	9.0 [1]
	4-(2-Bromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2h,6h)-dione	IC50	22.91 [1], 23.0 [2]
	9-Hydroxy-4-[2-(methylsulfanyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	33.0 [1]
	4-(2-Chlorophenyl)-6-ethyl-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	50.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-isopropylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	53.0 [1]
	4-(2,6-Dibromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	35.0 [1]
	4-(2-Chloro-5-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	41.69 [1], 42.0 [2]
	9-Hydroxy-4-(2-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	23.99 [1], 24.0 [2]
	9-Hydroxy-4-(2-thienyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	140.0 [1]
	4-(2-Chloro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	15.0 [1]
	4-(2,3-Dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	28.0 [1]
	4-(2,6-Dichloro-4-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	48.98 [1], 49.0 [2]
	4-(2-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2h,6h)-dione	IC50	210.0 [1]
	4-(2-Iodophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	13.0 [1]
	4-(2-Chloro-6-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	45.0 [1]
	9-Hydroxy-4-(4-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	67.0 [1]
	9-Hydroxy-4-(2-nitrophenyl)pyrrolo[3,4-c]carbazole-1,3(2h,6h)-dione	IC50	47.0 [1]
	4-(2,6-Dichloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	18.0 [1]
	4-(2,6-Dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	75.0 [1]
	4-(2-Acetylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	830.0 [1]
	9-Hydroxy-4-(2-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2h,6h)-dione	IC50	60.0 [1], 60.26 [2]
	4-(2,6-Dimethoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	27.0 [1]
	4-(4-Amino-2-bromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	20.0 [1]
	4-(2,6-Dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]pyrrolo[3,4-c]carbazole-1,3-dione	IC50	110.0 [1]
	4-(2-Chloro-3-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	12.0 [1]
	9-Hydroxy-4-iodopyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	2300.0 [1]
	9-Hydroxy-4-phenyl-6-thia-2-aza-cyclopenta[c]fluorene-1,3-dione	IC50	78.0 [1]
	5-Ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	1600.0 [1]
	9-Hydroxy-4,5-diphenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	2300.0 [1]
	9-Hydroxy-4-(4-(methylthio)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	29000.0 [1], 31622.78 [2]
	4-(2,3-Dimethylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	270.0 [1]
	4-(5-Amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	110.0 [1]
	4-(2-Fluoro-6-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	29.0 [1]
	9-Hydroxy-4-(1H-pyrrol-2-yl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	180.0 [1]
	9-Hydroxy-4-(3-pyridinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	575.44 [1], 580.0 [2]
	9-Hydroxy-4-phenyl-1,2-dihydropyrrolo[3,4-c]carbazol-3(6H)-one	IC50	37000.0 [1]
	4-(2-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	330.0 [1]
	4-(2-Ethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	510.0 [1]
	9-Hydroxy-4-[2-(hydroxymethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	450.0 [1]
	4-(2-Ethoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	260.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-propylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	63.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-pentylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	170.0 [1]
	9-Hydroxy-4-[2-(methylsulfinyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	220.0 [1]
	9-Hydroxy-4-m-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	230.0 [1]
	9-Hydroxy-4-(3-(hydroxymethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	870.0 [1]
	9-Hydroxy-4-(3-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	620.0 [1]
	4-(4-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	16000.0 [1]
	9-Hydroxy-4-p-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	3300.0 [1], 3311.31 [2]
	9-Hydroxy-4-(4-(hydroxymethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	1200.0 [1], 1202.26 [2]
	4-(4-Acetylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	3600.0 [1]
	9-Hydroxy-4-(4-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	12000.0 [1]
	4-(4-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	150.0 [1]
	4-(2,5-Dichlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	490.0 [1]
	4-(5-Amino-2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	20.0 [1]
	4-(2,5-Dimethylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	960.0 [1]
	4-(4-Amino-2-methoxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	19.0 [1]
	9-Hydroxy-4-(3-thienyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	42.0 [1]
	9-Hydroxy-4-(1H-pyrrol-3-yl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	38.0 [1]
	9-Hydroxy-4-(4-pyridinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	812.83 [1], 820.0 [2]
	4-(2-Chlorophenyl)-9-hydroxy-6-isopentylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	150.0 [1]
	9-Hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	97.0 [1], 4000.0 [2]
	8-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	310.0 [1]
	9-Hydroxy-4-phenyl-1H-benzofuro[3,2-e]isoindole-1,3(2H)-dione	IC50	430.0 [1]
	9-Hydroxy-5-methyl-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	130.0 [1]
	9-Hydroxy-4-methyl-5-phenylpyrrolo[3,4-c]carbazole-1,3(2h,6h)-dione	IC50	9700.0 [1]
	9-Hydroxy-5-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	4000.0 [1]
	2-Amino-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	3900.0 [1]
	4-(2-Chlorophenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	640.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-1H-benzofuro[3,2-e]isoindole-1,3(2H)-dione	IC50	33.0 [1], 33.11 [2]
	9-Hydroxy-4-o-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	150.0 [1]
	9-Hydroxy-4-(2-(trifluoromethyl)phenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	580.0 [1]
	2-(9-Hydroxy-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-c]carbazol-4-yl)benzonitrile	IC50	190.0 [1]
	4-(Biphenyl-2-yl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	570.0 [1]
	4-(3-Fluorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	220.0 [1]
	4-(3-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	55.0 [1]
	4-(3-(Aminomethyl)phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	4400.0 [1]
	4-(3-Acetylphenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione	IC50	4300.0 [1]
	9-Hydroxy-4-(3-hydroxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	89.0 [1], 89.13 [2]
	9-Hydroxy-4-(3-nitrophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	300.0 [1]
	4-(4-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	730.0 [1]
	4-(9-Hydroxy-1,3-dioxo-6H-pyrrolo[3,4-c]carbazol-4-yl)benzonitrile	IC50	1800.0 [1]
	4-(2-Chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3-dione	IC50	57.54 [1], 58.0 [2]
	3-(9-Hydroxy-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-c]carbazol-4-yl)benzonitrile	IC50	180.0 [1]
	4-(3-Amino-2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	21.0 [1]
	4-(3-Aminophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	70.0 [1]
	4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	45.0 [1]
	N-(Benzenesulfonyl)-3-[4-(2-chlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]propanamide	IC50	7.0 [1], 7.08 [2]
	4-(2-Chloro-4-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	23.0 [1]
	3-[4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]-N-[2-(dimethylamino)ethyl]propanamide	IC50	35.0 [1]
	4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	7.94 [1], 8.0 [2]
	3-[4-(2,6-Dichlorophenyl)-9-hydroxy-1,3-dioxopyrrolo[3,4-c]carbazol-6-yl]-N-[2-(dimethylamino)ethyl]propanamide	IC50	14.0 [1]
	4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-tetraazol-5-yl)ethyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	20.89 [1], 21.0 [2]
	3-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6(1h)-yl)propanoic acid	IC50	9.0 [1]
	9-Hydroxy-6-(3-hydroxypropyl)-4-(2-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	IC50	30.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-wee1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serine/threonine-protein kinase WEE1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serine-threonine-protein-kinase-wee1-inhibitors-ic50-ki.
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