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Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SumatriptanKi8.5 [1]
SerotoninIC503.0 [1]
SerotoninKi5.06 [1]
GR-127935IC5052.0 [1]
RizatriptanIC5011.0 [1], 79.43 [2]
RizatriptanKi4.3 [1], 13.5 [2], 40.0 [3]
6-((1-(2-((2-Methylquinolin-5-yl)oxy)ethyl)piperidin-4-yl)methyl)-2H-1,4-benzoxazin-3(4H)-oneKi1.58 [1]
3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,4-triazol-4-yl)-1H-indoleIC503.1 [1], 3.4 [2]
3-[3-(4-Benzylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC500.1 [1], 0.14 [2], 0.2 [3]
N-Benzyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamineIC500.5 [1], 0.6 [2]
ErgotamineKi0.8 [1], 2.2 [2], 4.3 [3], 6.0 [4]
ZolmitriptanIC502.82 [1]
ZolmitriptanKi0.76 [1], 0.92 [2], 4.0 [3]
CID 9847194IC500.9 [1]
CID 9847194Ki0.9 [1]
6-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-oneKi0.16 [1], 0.2 [2], 0.5 [3]
5-(4H-1,2,4-Triazole-4-yl)-3-[3-[4-(methylbenzylamino)piperidino]propyl]-1H-indoleIC502.1 [1], 2.2 [2]
1-[4-[2-Methylphenyl]piperazin-1-yl]-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanoneKi0.8 [1], 0.87 [2], 2.08 [3], 2.1 [4]
1-(4-Phenylpiperazin-1-yl)-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanoneKi0.4 [1], 0.6 [2], 1.2 [3]
SB 224289IC501000.0 [1]
SB 224289Ki260.0 [1], 501.19 [2]
4-Fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamideKi137.0 [1], 430.0 [2]
5-(4H-1,2,4-Triazole-4-yl)-3-[3-(4-benzylpiperidino)propyl]-1H-indoleIC500.3 [1], 0.35 [2]
3-[3-(4-Fluoro-4-benzylpiperidino)propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indoleIC500.9 [1], 1.0 [2]
N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamineIC50660.69 [1]
N-(3-(1-(2-(2-Methylquinolin-5-yloxy)ethyl)piperidin-4-ylmethyl)phenyl)methanesulfonamideKi0.5 [1]
8-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-1,4-benzoxazin-3-oneKi0.05 [1]
4-Methyl-8-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-oneKi0.1 [1], 0.32 [2]
1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamideKi8.0 [1], 56.0 [2]
N,N-Dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamineIC500.3 [1]
4-Methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-1,4-benzoxazin-3-oneKi0.1 [1], 0.32 [2]
1-[4-[4-(Acetylamino)phenyl]piperazin-1-yl]-2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]ethanoneKi1.4 [1], 1.7 [2], 2.8 [3]
Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl esterIC508.4 [1]
Trifluoro-methanesulfonic acid 3-(2-dimethylamino-ethyl)-1H-indol-5-yl esterKi3.2 [1], 30.0 [2]
Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl esterIC5021.0 [1]
Trifluoro-methanesulfonic acid 3-(2-diethylamino-ethyl)-1H-indol-5-yl esterKi12.0 [1], 29.0 [2]
Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl esterIC50170.0 [1]
Trifluoro-methanesulfonic acid 3-(2-dipropylamino-ethyl)-1H-indol-5-yl esterKi36.0 [1], 190.0 [2]
8-OH-DpatKi115.0 [1], 164.0 [2]
KetanserinIC50260.0 [1], 270.0 [2]
MianserinIC50380.19 [1]
TryptamineKi23.0 [1], 61.0 [2]
TolazolineKi10000.0 [1]
5-MethoxytryptamineKi4.1 [1], 5.4 [2]
N,N-Dimethyl-5-methoxytryptamineIC5049.0 [1]
N,N-Dimethyl-5-methoxytryptamineKi20.0 [1]
XylometazolineKi0.7 [1]
1-NaphthylpiperazineKi6.18 [1], 6.2 [2]
(7R)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-olKi164.0 [1], 638.0 [2]
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamideKi0.3 [1], 104.0 [2]
2-Ethyl-5-methoxy-N,N-dimethyltryptamineIC501400.0 [1]
2-Ethyl-5-methoxy-N,N-dimethyltryptamineKi290.0 [1]
N,N-Diallyl-5-methoxytryptamineKi158.49 [1], 10000.0 [2]
(1S)-1-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamideKi0.9 [1]
CID 9870500Ki1.0 [1], 2.0 [2]
N,N-Di-n-propylserotoninIC50820.0 [1]
N,N-Dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amineKi39.0 [1], 40.0 [2]
Dipropyl-(S)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amineKi440.0 [1], 441.0 [2]
Dipropyl-(R)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl-amineKi16.0 [1]
5-Chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamideKi199.53 [1]
2-Methyl-5-(2-(4-(quinolin-8-ylmethyl)piperazin-1-yl)ethoxy)quinolineKi0.79 [1]
3-[2-Fluoro-3-(4-benzylpiperidino)propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indoleIC500.9 [1], 0.95 [2]
2-(Dipropylamino)-8-[(trifluoromethylsulfonyl)-oxy]tetralinKi12.0 [1], 127.0 [2]
Trifluoro-methanesulfonic acid 7-propylamino-5,6,7,8-tetrahydro-naphthalen-1-yl esterKi15.0 [1], 169.0 [2]
2-(2,6-Dimethyl-benzyl)-4,5-dihydro-1H-imidazoleKi2210.0 [1]
4-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrileKi120.0 [1]
2-(Dimethylamino)-N-[3-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]phenyl]acetamideKi1.0 [1]
Methyl 1-[3-[[2,6-dimethyl-5-(methylcarbamoyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylateKi5000.0 [1], 8840.0 [2]
1-(17-Chloro-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl)-N,N-dimethylmethanamineIC50134.9 [1]
N-Benzyl-N-methyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamineIC500.7 [1]
3-[3-[4-Fluoro-4-(3-fluorophenethyl)piperidino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indoleIC500.7 [1], 0.75 [2]
3-[3-[4-(2-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC500.5 [1], 0.6 [2]
3-[3-[4-(4-Fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC500.8 [1]
3-[2-Fluoro-3-[4-(3-fluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indoleIC503.5 [1], 3.7 [2]
Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-amineIC504.6 [1], 4.8 [2]
3-[2-(4-Methylpiperazino)ethyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC50134.0 [1], 140.0 [2]
(3R)-N-Benzyl-N-methyl-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-amineIC5037.0 [1], 38.0 [2]
3-[3-(4-Phenethylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC501.4 [1]
(R)-beta-[[1-[3-[5-(4H-1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]amino]benzeneethanolIC501.3 [1]
3-(3-Piperidinopropyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC5024.0 [1]
3-[2-((R)-3-Benzyloxymethyl-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indoleIC502.3 [1]
N-[(1R)-1-Phenylethyl]-1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-amineIC500.35 [1], 0.4 [2]
N-Benzyl-N-methyl-1-[1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-yl]methanamineIC500.9 [1], 0.95 [2]
Benzyl-{(R)-1-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-pyrrolidin-3-ylmethyl}-amineIC501.6 [1]
N-[4-[2-[4-[3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl]piperazin-1-yl]ethyl]phenyl]acetamideIC501.3 [1]
2-(5-((4-((3-(2-Aminoethyl)-1H-indol-5-yloxy)methyl)phenyl)methoxy)-1H-indol-3-yl)ethanamineKi0.11 [1]
2-(5-(2-(8-(4-Methylpiperazin-1-yl)naphthalen-2-yloxy)ethoxy)-1H-indol-3-yl)ethanamineKi0.4 [1]
(3R,4S)-N-Benzyl-3-fluoro-N-methyl-1-[3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]piperidin-4-amineIC502.2 [1], 12.0 [2]
3-(2-Piperidinoethyl)-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC50200.0 [1]
1H-Indole-3-ethanamine, N,N'-dimethyl-5-(phenylmethoxy)-IC5025.0 [1], 76.0 [2]
3-[3-[4-(3,4-Difluorophenethyl)piperazino]propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC500.9 [1], 1.0 [2]
2-(4-Bromo-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazoleKi74.0 [1]
3-[2-Fluoro-3-[4-(methylbenzylamino)piperidino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indoleIC505.4 [1]
1-Methyl-2-(2,6-dimethyl-4-tert-butylbenzyl)-2-imidazolineKi86.0 [1]
1-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[[4-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methylsulfonyl-methylamino]methyl]phenyl]methyl]-N-methylmethanesulfonamideKi0.89 [1]
N,N-Dimethyl-2-(5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-3-yl)ethanamineKi8.0 [1]
3-[2-((R)-3-Benzyloxy-pyrrolidin-1-yl)-ethyl]-5-[1,2,4]triazol-4-yl-1H-indoleIC506.3 [1], 23.0 [2]
3-[3-(4-Methylpiperazino)propyl]-5-(4H-1,2,4-triazol-4-yl)-1H-indoleIC5033.0 [1], 35.0 [2]
Items per page: 1 - 10 of 98
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References

This online tool may be cited as follows

MLA

"Quest Database™ Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/serotonin-1d-5-ht1d-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Serotonin 1d (5-HT1d) receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/serotonin-1d-5-ht1d-receptor-inhibitors-ic50-ki.
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