Short transient receptor potential channel 6 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	7-Bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide	IC50	25000.0 [1]
	3,4-Dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone	IC50	500.0 [1]
	4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile	IC50	9.5 [1]
	(4-Methylpiperidino)[2-(4-toluidino)-1,3-thiazol-4-yl]methanone	IC50	400.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone	IC50	16.0 [1]
	Chembl4127600	IC50	11.0 [1]
	4-[(3S,4R)-1-(2,4-Dichlorophenyl)sulfonyl-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl]oxy-2-fluorobenzonitrile	IC50	10000.0 [1]
	(2E)-2-[(1R,2R,3As,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-1-(4-cyanophenoxy)-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-5-ylidene]-N,N-dimethylacetamide	IC50	280.0 [1]
	4-[[(1R,2R,3Ar,5R,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	52.0 [1]
	4-[[(1R,2R,3Ar,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5,5-difluoro-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile	IC50	30.0 [1]
	4-[[(1R,2R,3Ar,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	440.0 [1]
	4-[[(1R,2R,3As,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	37.0 [1]
	4-[[(1R,2R,3Ar,5E,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxyimino-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile	IC50	33.0 [1]
	4-[[(1R,2R,3R,5R)-3-[(3R)-3-Aminopiperidin-1-yl]-6-oxo-2-bicyclo[3.2.0]heptanyl]oxy]benzonitrile	IC50	160.0 [1]
	4-[[(1R,2R,3Ar,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-5,7a-dimethyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile	IC50	210.0 [1]
	4-[(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]cyclopentyl]oxybenzonitrile	IC50	500.0 [1]
	4-[(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]cyclopentyl]oxy-3-chlorobenzonitrile	IC50	660.0 [1]
	4-[[(1S,2R,3R,4R,6R,7S)-4-[(3R)-3-Aminopiperidin-1-yl]-9-oxo-3-tricyclo[5.2.1.02,6]decanyl]oxy]benzonitrile	IC50	8.0 [1]
	4-[[(1R,2R,3Ar,6aR)-2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-2,3,3a,5,6,6a-hexahydro-1H-pentalen-1-yl]oxy]benzonitrile	IC50	22.0 [1]
	4-[[(1R,2R,3Ar,5R,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	49.0 [1]
	4-[[(1R,2R,3As,7aR)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-5-oxo-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile	IC50	390.0 [1]
	4-[[(1R,2R,3As,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-(difluoromethyl)-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	200.0 [1]
	4-[[(1R,2R,3Ar,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-7a-methyl-1,2,3,3a,6,7-hexahydroinden-1-yl]oxy]benzonitrile	IC50	3.0 [1]
	4-[[(1R,2R,3Ar,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile	IC50	560.0 [1]
	{2-[(4-Methoxyphenyl)amino]-1,3-thiazol-4-yl}(4-methylpiperidin-1-yl)methanone	IC50	800.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone	IC50	160.0 [1]
	[2-(4-Chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone	IC50	800.0 [1]
	[2-(2-Chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone	IC50	3160.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone	IC50	630.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone	IC50	160.0 [1]
	[2-(4-Methylanilino)-1,3-thiazol-4-yl]-(2-methylpiperidin-1-yl)methanone	IC50	630.0 [1]
	[2-(4-Methylanilino)-1,3-thiazol-4-yl]-(2-phenylpiperidin-1-yl)methanone	IC50	15800.0 [1]
	[2-(4-Methylanilino)-1,3-thiazol-4-yl]-(3-phenylpiperidin-1-yl)methanone	IC50	25000.0 [1]
	[2-(4-Methoxyanilino)-1,3-thiazol-4-yl]-(4-phenylpiperidin-1-yl)methanone	IC50	1600.0 [1]
	(4-Cyclohexylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone	IC50	4000.0 [1]
	(2,3-Dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone	IC50	80.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone	IC50	16.0 [1]
	(2,3-Dimethylpiperidin-1-yl)-[2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-5-methyl-1,3-thiazol-4-yl]methanone	IC50	25.0 [1]
	[5-Chloro-2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone	IC50	4.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone	IC50	50.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2R,3R)-2,3-dimethylpiperidin-1-yl]methanone	IC50	1600.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone	IC50	63.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone	IC50	32.0 [1]
	[2-(1,3-Benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(5-methyl-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone	IC50	1260.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone	IC50	6300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 45 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Short transient receptor potential channel 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/short-transient-receptor-potential-channel-6-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Short transient receptor potential channel 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/short-transient-receptor-potential-channel-6-inhibitors-ic50-ki.
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