Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	25000.0 [1], 50000.0 [2]
	Sodium	IC50	9100.0 [1]
	NF449 octasodium salt	IC50	7900.0 [1]
	5,15-Diphenyl-21H,23H-porphine	IC50	10000.0 [1]
	4,6,8-Trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine	IC50	5900.0 [1]
	6-(4-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	CID 4378002	IC50	50000.0 [1]
	(7-Ethoxy-4-methylquinazolin-2-yl)(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)amine	IC50	50000.0 [1]
	6-(4-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Phenyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	CID 665910	IC50	50000.0 [1]
	4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	9700.0 [1]
	5,6-Dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-one	IC50	50000.0 [1]
	5-Benzyl-2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4(1H)-one	IC50	50000.0 [1]
	2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one	IC50	50000.0 [1]
	6-Methyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(3H)-one	IC50	12100.0 [1]
	2-[(7-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-ol	IC50	50000.0 [1]
	4-[[2-[(4-Chlorophenyl)sulfonyl-methylamino]acetyl]-[(4-cyclohexylphenyl)methyl]amino]-2-hydroxybenzoic acid	Ki	22000.0 [1]
	4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-phenylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	8800.0 [1]
	4-[[4-[1-(4-Cyanophenyl)sulfonylpiperidin-4-yl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	25000.0 [1]
	4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acid	Ki	25000.0 [1]
	4-[[4-[4-(4-Carbamoylphenyl)phenyl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	9500.0 [1]
	(2S)-2-[[(2S)-2-[(4-Cyanobenzoyl)amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-methylpentanoic acid	IC50	42000.0 [1]
	4-Methyl-N-phenylquinazolin-2-amine	IC50	30000.0 [1]
	N-Benzyl-4-methylquinazolin-2-amine	IC50	30000.0 [1]
	N-[2-(1H-Indol-3-yl)ethyl]-4-methylquinazolin-2-amine	IC50	30000.0 [1]
	4-Methyl-N-(2-morpholin-4-ylethyl)quinazolin-2-amine	IC50	30000.0 [1]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-methylquinazolin-2-amine	IC50	30000.0 [1]
	4-Methyl-N-[(5-methylfuran-2-yl)methyl]quinazolin-2-amine	IC50	30000.0 [1]
	4-Methyl-N-(naphthalen-1-ylmethyl)quinazolin-2-amine	IC50	30000.0 [1]
	N-Cyclohexyl-4-methylquinazolin-2-amine	IC50	30000.0 [1]
	4-Methyl-N-pyridin-2-ylquinazolin-2-amine	IC50	30000.0 [1]
	6-(3,4-Dichlorophenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(4-Methoxyphenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	3-(3-Phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Cyclohexyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-Cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	3-(3-Phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(5-Chlorothiophen-2-yl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(5-Chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(3-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	45900.0 [1]
	6-Pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	3-(1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(4-Methoxyphenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(3-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(4-Methoxyphenyl)-7-(2-methylpropyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	3-[3-(4-Fluorophenyl)-1H-pyrazol-5-yl]-6-(4-methoxyphenyl)-7-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	30000.0 [1]
	6-(3,4-Dichlorophenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(3,4-Dichlorophenyl)-7-(2-methylpropyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	7-Benzyl-6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(3,4-Dichlorophenyl)-7,7-dimethyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	7-Methyl-6-phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	15000.0 [1]
	3-[3-(4-Fluorophenyl)-1H-pyrazol-5-yl]-7-methyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	30000.0 [1]
	(1S,3R,4S,6S,8R,9R,10R,12R,13R)-10-Hydroxy-4,9,12-trimethyl-13-propan-2-yl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecane-5,11-dione	IC50	7000.0 [1]
	(1S,3R,4S,6S,8R,9S,12R,13R)-4,9,12-Trimethyl-13-propan-2-yl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecane-5,11-dione	IC50	2000.0 [1]
	(1S,3R,4S,5R,6R,8R,9S,12R,13R)-13-Ethenyl-5-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-11-one	IC50	50000.0 [1]
	(1R,3R,4S,6S,8R,9S,11S,12R,13R)-13-Ethenyl-11-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-5-one	IC50	2000.0 [1]
	2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-ol	IC50	50000.0 [1]
	5,6-Dimethyl-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-4(1H)-pyrimidinone	IC50	50000.0 [1]
	2-[(6-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-ol	IC50	50000.0 [1]
	2-[(4,7-Dimethyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone	IC50	35200.0 [1]
	6-Phenyl-2-[(4,6,8-trimethyl-2-quinazolinyl)amino]-4-pyrimidinol	IC50	50000.0 [1]
	2-[(4,7-Dimethylquinazolin-2-yl)amino]-6-methylpyrimidin-4(3H)-one	IC50	39700.0 [1]
	6-Methyl-2-[(4,6,7-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol	IC50	50000.0 [1]
	2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-6-phenylpyrimidin-4-ol	IC50	50000.0 [1]
	6-Methyl-5-(prop-2-en-1-yl)-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(3H)-one	IC50	50000.0 [1]
	5-Benzyl-2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-4-methyl-1H-pyrimidin-6-one	IC50	50000.0 [1]
	4-Methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one	IC50	50000.0 [1]
	4,5-Dimethyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one	IC50	50000.0 [1]
	2-[(8-Methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-4-phenyl-1H-pyrimidin-6-one	IC50	50000.0 [1]
	5-Benzyl-4-methyl-2-[(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)amino]-1H-pyrimidin-6-one	IC50	50000.0 [1]
	6-(4-Methoxyphenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	6-(4-Methoxyphenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	40600.0 [1]
	[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(3-methoxyanilino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	560000.0 [1]
	[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(3-hydroxypropylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	210000.0 [1]
	[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	605000.0 [1]
	[4-[(2S)-3-[[(2S)-1-Anilino-4-methyl-1-oxopentan-2-yl]amino]-2-[(4-cyanobenzoyl)amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	380000.0 [1]
	[4-[(2S)-3-[[(2S)-1-(Benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-2-[(4-cyanobenzoyl)amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	760000.0 [1]
	[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-4-methyl-1-(2-methylpropylamino)-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	760000.0 [1]
	[4-[(2S)-2-[(4-Cyanobenzoyl)amino]-3-[[(2S)-4-methyl-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	402000.0 [1]
	6-(3,4-Dichlorophenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	IC50	50000.0 [1]
	4,6-Dimethyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine	IC50	50000.0 [1]
	4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[[2-(trifluoromethyl)phenyl]methyl]amino]acetyl]amino]-2-hydroxybenzoic acid	IC50	5800.0 [1]
	2-Hydroxy-4-[[4-[4-(3-methoxycarbonylphenyl)phenyl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]benzoic acid	Ki	3200.0 [1]
	4-[Benzyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acid	Ki	25000.0 [1]
	4-[[4-[1-(4-Carbamoylphenyl)piperidin-4-yl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid	Ki	27800.0 [1]
	Hexasodium;8-[[3-[[3-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]benzoyl]amino]naphthalene-1,3,5-trisulfonate;hydrate	IC50	33200.0 [1]
	4-[(4-Cyclohexylphenyl)methyl-[2-[(2,3,4,5,6-pentafluorophenyl)sulfonyl-[[2-(trifluoromethyl)phenyl]methyl]amino]acetyl]amino]-2-hydroxybenzoic acid	IC50	10900.0 [1]
	[(5R,5As,9R,9aR,9bR)-9,9b-dihydroxy-6,6,9a-trimethyl-1-oxo-3,5,5a,7,8,9-hexahydrobenzo[e][2]benzofuran-5-yl] hexanoate	IC50	50700.0 [1]
	STAT5 Inhibitor	IC50	130000.0 [1]
	N-[4-(4-Chlorophenyl)-1,2,5-oxadiazol-3-yl]-4-(trifluoromethyl)benzamide	IC50	7200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 94 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-1-alpha-beta-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Signal transducer and activator of transcription 1-alpha/beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-1-alpha-beta-inhibitors-ic50-ki.
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