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Signal transducer and activator of transcription 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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7,18-Bis[3-(dimethylamino)propyl]-7,18-diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,24]hexacosa-1(23),2,4,9,11,13,15,20(24),21,25-decaene-6,8,17,19-tetroneIC504500.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidIC5031000.0 [1], 35000.0 [2]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi15000.0 [1], 15500.0 [2]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50150.0 [1]
CID 53388144IC506800.0 [1], 19700.0 [2], 25600.0 [3]
CID 53388144Ki12800.0 [1]
2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acidIC5084000.0 [1], 86000.0 [2]
2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acidKi80000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5019250.0 [1], 33900.0 [2]
[4-[(E)-3-[[(2S)-1-[(2S)-2-[[(2S)-5-Amino-1-(benzylamino)-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphateIC50135.0 [1], 138.0 [2]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-1,5-diamino-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50856.0 [1], 1000.0 [2]
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acidIC5015800.0 [1], 115000.0 [2]
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetyl]amino]-2-hydroxybenzoic acidKi7900.0 [1]
StatticIC505100.0 [1]
Azd-1480IC5023.0 [1], 80.0 [2]
4-[({3-[(Carboxymethyl)thio]-4-hydroxy-1-naphthyl}amino)sulfonyl]benzoic acidIC5020000.0 [1], 73000.0 [2]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-(benzylamino)-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50409.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi8000.0 [1]
[(1R,2E,8S,10R,11S)-6-(Acetyloxymethyl)-11-hydroxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] (E)-2-methylbut-2-enoateIC502200.0 [1], 2300.0 [2]
[(2S)-3-(Benzylamino)-2-[[(2S)-1-[(2S)-4-methyl-2-[[(E)-3-(4-phosphonooxyphenyl)prop-2-enoyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-3-oxopropyl] carbamateIC50379.0 [1]
[(2R,3S)-4-(Benzylamino)-3-[[(2S)-1-[(2S)-4-methyl-2-[[(E)-3-(4-phosphonooxyphenyl)prop-2-enoyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutan-2-yl] carbamateIC50850.0 [1]
4-[[2-[(4-Chlorophenyl)sulfonyl-methylamino]acetyl]-[(4-cyclohexylphenyl)methyl]amino]-2-hydroxybenzoic acidKi11000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(4-phenylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi6200.0 [1]
4-[[4-[1-(4-Cyanophenyl)sulfonylpiperidin-4-yl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi8400.0 [1], 21500.0 [2]
4-[[4-[4-(4-Carbamoylphenyl)phenyl]phenyl]methyl-[2-[methyl-(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidKi8400.0 [1], 16700.0 [2]
Vernolide-BIC503200.0 [1], 4100.0 [2]
4-[(4-Cyclohexylphenyl)methyl-[2-(4-methylphenyl)sulfonyloxyacetyl]amino]-2-hydroxybenzoic acidIC5043000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-(4-methylphenyl)sulfonyloxyacetyl]amino]-2-hydroxybenzoic acidKi50000.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC5020000.0 [1]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateKi25900.0 [1]
5,8-Dioxo-6-(2-piperazin-1-ylanilino)naphthalene-1-sulfonamideKi440.0 [1], 2420.0 [2]
Methyl 4-({[3-(2-methoxy-2-oxoethyl)-4,8-dimethyl-2-oxo-2H-chromen-7-yl]oxy}methyl)benzoateIC5063000.0 [1], 137000.0 [2]
3-[[2-Chloro-4-[(1,3-dioxoinden-2-ylidene)methyl]-6-ethoxyphenoxy]methyl]benzoic acidIC50144000.0 [1], 256000.0 [2]
4-[5-[(Z)-(3-Ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoic acidIC5018000.0 [1], 30000.0 [2]
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphateIC50600.0 [1], 739.0 [2]
4-[3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-oxo-propenyl]-benzoic acidIC5091000.0 [1], 447000.0 [2]
4-[(4-Cyclohexylphenyl)methyl-[2-[(4-methylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acidIC5050000.0 [1], 95000.0 [2]
[(1R,2E,8S,10R,11S)-8,11-Dihydroxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-6-yl]methyl (E)-2-methylbut-2-enoateIC502400.0 [1], 2600.0 [2]
4-Chloro-3-[5-[(1,3-diethyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]furan-2-yl]benzoic acidIC5060000.0 [1], 114000.0 [2]
GenisteinIC5024800.0 [1]
Oleanolic acidIC5050000.0 [1]
NiclosamideIC50250.0 [1]
CryptotanshinoneIC504600.0 [1]
LevomenolIC5073000.0 [1]
Bardoxolone methylIC502380.0 [1]
LoganinIC5014000.0 [1]
PiperlongumineIC507000.0 [1]
TetrahydrocurcuminIC5050000.0 [1]
SwerosideIC5089500.0 [1]
MorronisideIC506900.0 [1]
Ar-TurmeroneIC5014210.0 [1]
(1E,4E)-1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-oneIC506000.0 [1]
HydrazinocurcuminIC5016200.0 [1]
IncensoleIC5015840.0 [1]
[(E,6R)-6-[(2S,8S,9R,10S,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetateIC503000.0 [1]
Incensole acetateIC5050000.0 [1]
N-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-2-phenylquinoline-4-carboxamideIC5074000.0 [1]
(2S,3R,4S)-3,4-Dihydroxy-6-methoxy-3-methyl-7-methylidene-2-pentyl-2,4-dihydropyrano[2,3-c]pyrrol-5-oneIC50610000.0 [1]
5,15-Diphenyl-21H,23H-porphineIC50280.0 [1]
4,6,8-Trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amineIC50800.0 [1]
Methyl (4aS,6aR,6aS,6bR,8aR,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylateIC5025000.0 [1]
6-(4-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC509600.0 [1]
2-Phenyl-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)quinoline-4-carboxamideIC5075000.0 [1]
CID 4378002IC5015700.0 [1]
(7-Ethoxy-4-methylquinazolin-2-yl)(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)amineIC5020700.0 [1]
6-(4-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5026800.0 [1]
6-Phenyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5027000.0 [1]
6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
6-Phenyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5021200.0 [1]
6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
CID 665910IC506800.0 [1]
6-(3-Pyridylamino)-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamideKi2500.0 [1]
4-Bromo-2-[3-(2,4-dichlorophenyl)acryloyl]-7-(methylamino)-2,4,6-cycloheptatrien-1-oneKi1400.0 [1]
8-EpiloganinIC5022900.0 [1]
CID 72188643Ki10000.0 [1]
Methyl (1S,3R,4aS,8S,8aS)-3-methoxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylateIC5024800.0 [1]
(1S,3E,7E,11E)-4,8,12-Trimethyl-1-propan-2-ylcyclotetradeca-3,7,11-trien-1-olIC5050000.0 [1]
5-[(4-Cyclohexylphenyl)methyl-(4-phenoxybenzoyl)amino]-2-hydroxybenzoic acidIC5015000.0 [1]
5,6-Dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-oneIC506400.0 [1]
5-Benzyl-2-[(6-ethoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4(1H)-oneIC502700.0 [1]
2-[(6-Ethoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-oneIC5011700.0 [1]
6-Methyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(3H)-oneIC505000.0 [1]
2-[(7-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-olIC5033900.0 [1]
4-[(E)-2-[3-(4-Hydroxy-3-methoxyphenyl)-1H-pyrazol-5-yl]ethenyl]-2-methoxyphenolIC5018200.0 [1]
Methyl (4aS,6aR,6aS,6bR,8aR,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,13,14b-decahydro-1H-picene-4a-carboxylateIC5025000.0 [1]
(7alpha-Hydroxy)-MorronisideIC507000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl(quinolin-8-ylsulfonyl)amino]acetyl]amino]-2-hydroxybenzoic acidKi41000.0 [1]
Methyl (1S,3S,4aS,8S,8aS)-3-methoxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylateIC5032500.0 [1]
1,7-Bis[4-hydroxy-3-methoxy-5-(3-methylbutyl)phenyl]heptane-3,5-dioneIC5050000.0 [1]
4-[(4-Cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-N-hydroxybenzamideKi10000.0 [1]
(1E,6E)-1,7-Bis[4-hydroxy-3-methoxy-5-(3-methylbut-2-enyl)phenyl]hepta-1,6-diene-3,5-dioneIC5050000.0 [1]
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-1-(2-Aminoacetyl)pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S,3S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]pentanediamideIC50300.0 [1]
(1E,4E)-1,5-Bis[4-hydroxy-3-methoxy-5-(3-methylbut-2-enyl)phenyl]penta-1,4-dien-3-oneIC5022400.0 [1]
(2S)-2-[[(2S)-2-[(4-Cyanobenzoyl)amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-methylpentanoic acidIC50310000.0 [1]
(6S)-2-Methyl-6-[(2R,3R,5R,8R,9R,10R,12R,13R,14R,17S)-2,3,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxyhept-1-en-3-oneIC50590.0 [1]
(2R,3R,4R,5R,6S)-2-[[(2R,3S,4S,5R,6S)-6-[(E,2S)-2-[(2R,3R,5R,8R,9R,10R,12R,13R,14R,17S)-2,12-Dihydroxy-4,4,8,10,14-pentamethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-6-methylhept-4-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-methyloxane-3,4,5-triolIC5017100.0 [1]
4-[[2-[(4-Chlorophenyl)methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(3,5-ditert-butylphenyl)methyl]amino]-2-hydroxybenzoic acidKi143800.0 [1]
(4Ar,6aR,6bS,8aS,12aS,14aR,14bR)-8a-methoxycarbonyl-4,4,6a,6b,11,11,14b-heptamethyl-3-oxo-5,6,7,8,9,10,12,12a,14,14a-decahydro-4aH-picene-2-carboxylic acidIC5025740.0 [1]
Methyl (4aS,6aR,6aS,6bR,8aR,12aR,14bS)-11-cyano-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydropicene-4a-carboxylateIC5025000.0 [1]
Dimethyl (4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-3-oxo-5,6,7,8,9,10,12,12a,14,14a-decahydro-4aH-picene-2,8a-dicarboxylateIC5025000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Signal transducer and activator of transcription 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Signal transducer and activator of transcription 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/signal-transducer-and-activator-of-transcription-3-inhibitors-ic50-ki.
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