 | Vismodegib | IC50 | 7.0 [1], 20.0 [2], 23.0 [3], 33.0 [4] |
| Vismodegib | Ki | 16.2 [1] |
 | Cyclopamine | IC50 | 64.0 [1], 280.0 [2], 300.0 [3] |
| Cyclopamine | Ki | 12.7 [1], 232.0 [2] |
 | N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide | IC50 | 281.0 [1], 300.0 [2], 650.0 [3] |
 | N-[(3-Benzamidophenyl)carbamoyl]-3,4,5-trimethoxybenzamide | IC50 | 107.0 [1], 160.0 [2] |
 | N-(4,4-Difluorocyclohexyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 13.0 [1], 39.0 [2] |
 | (8As)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 13.0 [1], 17.0 [2], 22.0 [3] |
 | (8As)-N-[2-(3-chlorophenyl)pyrazol-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 8.0 [1], 18.0 [2], 32.0 [3] |
 | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 15.0 [1], 18.0 [2] |
 | (8As)-N-[2,6-dichloro-4-(dimethylcarbamoyl)phenyl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 77.0 [1], 120.0 [2] |
 | (8As)-N-(2,6-dichloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 140.0 [1], 180.0 [2], 520.0 [3] |
 | (8As)-N-(2,6-dichloro-4-cyanophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 100.0 [1], 120.0 [2], 450.0 [3] |
 | (8As)-N-[2-(3-chlorophenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 4.0 [1], 5.0 [2], 15.0 [3] |
 | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 21.0 [1], 42.0 [2], 89.0 [3] |
 | (8Ar)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1200.0 [1], 1400.0 [2], 1600.0 [3] |
 | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 21.0 [1], 42.0 [2], 70.0 [3] |
 | (8As)-N-(2,3-dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 230.0 [1], 270.0 [2], 690.0 [3] |
 | (8As)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 19.0 [1], 23.0 [2], 60.0 [3] |
 | (8As)-N-[2-(3-cyanophenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 5.0 [1], 16.0 [2], 22.0 [3] |
 | (8As)-N-(2,6-dichloro-4-methylsulfonylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 41.0 [1], 42.0 [2], 68.0 [3] |
 | (8As)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 12.0 [1], 28.0 [2] |
 | (8As)-N-[2-(3-fluorophenyl)pyrazol-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 6.0 [1], 7.0 [2], 9.0 [3] |
 | Sant-1 | IC50 | 4.74 [1], 25.0 [2] |
 | 3,4,5-Trimethoxy-N-[N'-[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamimidoyl]benzamide | IC50 | 5.0 [1], 15.0 [2] |
 | 1-((5-Methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine | IC50 | 78.4 [1], 96.0 [2] |
 | (R)-(3-Methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 2.8 [1] |
 | 3-Fluoro-N-[4-methyl-3-[[4-(pyridin-2-ylmethoxy)benzoyl]amino]phenyl]-5-pyrrolidin-1-ylbenzamide | IC50 | 450.0 [1], 30000.0 [2] |
 | Nvp-leq-506 | IC50 | 100.0 [1] |
 | (R)-(3-Methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 2.2 [1] |
 | (S)-(3-Methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 5.3 [1], 11.0 [2] |
 | (4-(4-(3,4-Dichlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone | IC50 | 17.0 [1], 17.3 [2] |
 | (R)-(4-(4-(4-(Hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | IC50 | 2.7 [1] |
 | (R)-(4-(4-(4-(Dimethylamino)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone | IC50 | 5.2 [1], 5.3 [2] |
 | Phenyl[4-(4-phenyl-1-phthalazinyl)piperazino]methanone | IC50 | 19.0 [1] |
 | N-[N'-(3-Benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide | IC50 | 290.0 [1] |
 | CID 44610687 | IC50 | 380.0 [1], 3500.0 [2] |
 | N-(2-Chloro-5-methylsulfonylphenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 1200.0 [1], 2500.0 [2] |
 | N-(2-Chloro-4-methylsulfonylphenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 1500.0 [1], 4100.0 [2] |
 | N-(2-Chloro-5-cyanophenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 320.0 [1], 2500.0 [2] |
 | N-(2-Chlorophenyl)-4-[3-(5-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
 | N-[[1-(Cyclohexylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 140.0 [1], 520.0 [2] |
 | N-(2-Chlorophenyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 170.0 [1], 700.0 [2] |
 | 1-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(2-methoxyphenyl)piperazine | IC50 | 1870.0 [1], 5000.0 [2] |
 | 1-((1-(4-Fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)-4-(4-methoxyphenyl)piperazine | IC50 | 1690.0 [1], 2000.0 [2] |
 | 1-((1-(4-Fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)-4-(3-methoxyphenyl)piperazine | IC50 | 20.0 [1], 823.0 [2] |
 | 1-(4-Methoxyphenyl)-4-[(3-methyl-1-phenylpyrazol-4-yl)methyl]piperazine | IC50 | 5000.0 [1] |
 | 1-(4-Fluorophenyl)-4-[(3-methyl-1-phenylpyrazol-4-yl)methyl]piperazine | IC50 | 5000.0 [1] |
 | 1-[(5-Methyl-1-phenylpyrazol-4-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine | IC50 | 328.0 [1], 333.0 [2] |
 | 1-(4-Methoxyphenyl)-4-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)piperazine | IC50 | 105.0 [1], 126.0 [2] |
 | 1-[[1-(4-Fluorophenyl)-5-methylpyrazol-4-yl]methyl]-4-(3-methoxyphenyl)piperazine | IC50 | 5.0 [1], 64.7 [2] |
 | 4-[[3-(2,5-Dimethoxyphenyl)pyrrolidin-1-yl]methyl]-1-(2-fluorophenyl)-5-methylpyrazole | IC50 | 40.8 [1], 216.0 [2] |
 | 4-((3-(2-Fluoro-6-methoxyphenoxy)azetidin-1-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole | IC50 | 8.27 [1], 124.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyrazol-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 13.0 [1], 16.0 [2] |
 | 4-[3-(1-Methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]piperazine-1-carboxamide | IC50 | 5.0 [1], 6.0 [2] |
 | N-[[1-(Ethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 46.0 [1], 91.0 [2] |
 | N-(2-Morpholin-4-yl-2-pyridin-3-ylethyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 2600.0 [1], 9900.0 [2] |
 | N-[[1-(Piperidine-1-carbonyl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 230.0 [1], 7000.0 [2] |
 | Tert-butyl N-[1-[[[4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carbonyl]amino]methyl]cyclopentyl]carbamate | IC50 | 2000.0 [1], 14000.0 [2] |
 | N-(4,4-Difluorocyclohexyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 480.0 [1], 1500.0 [2] |
 | N-(2-Chlorophenyl)-4-[3-(4-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
 | N-(2-Chlorophenyl)-4-[3-(7-methoxyquinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 2500.0 [1] |
 | 1,3-Dioxo-2-(2-phenylethyl)-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 2000.0 [1], 5000.0 [2] |
 | 2-(2,3-Dihydro-1H-inden-2-yl)-1,3-dioxo-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 320.0 [1], 880.0 [2] |
 | N-(2-Chloro-4-cyano-6-methylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 84.0 [1], 150.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-[2-(trifluoromethyl)phenyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 890.0 [1], 1100.0 [2] |
 | N-(2-Chloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1100.0 [1] |
 | N-(1,3-Benzodioxol-5-yl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 700.0 [1], 2700.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 210.0 [1], 220.0 [2] |
 | N-[2-(3-Methoxyphenyl)pyridin-3-yl]-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 47.0 [1], 82.0 [2] |
 | N-[[1-(Diethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 46.0 [1], 55.0 [2] |
 | N-[(1-Propan-2-ylpyrrolidin-2-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 340.0 [1], 650.0 [2] |
 | N-[(1-Ethylpiperidin-2-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 64.0 [1], 80.0 [2] |
 | N-[(1-Morpholin-4-ylcyclohexyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 23.0 [1], 72.0 [2] |
 | Methyl 2-chloro-3-[[1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carbonyl]amino]benzoate | IC50 | 1100.0 [1], 2200.0 [2] |
 | N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 370.0 [1], 460.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-propan-2-ylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 180.0 [1], 210.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 12.0 [1], 28.0 [2] |
 | 3-Oxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1400.0 [1], 3000.0 [2] |
 | N-(2-Phenyl-2-piperidin-1-ylethyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 210.0 [1], 330.0 [2] |
 | 4-(3-Quinolin-2-yl-1,2,4-oxadiazol-5-yl)-N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)piperidine-1-carboxamide | IC50 | 380.0 [1], 600.0 [2] |
 | N-(2,3-Dichloro-4-fluorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 480.0 [1], 510.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-thiophen-3-ylpyridin-3-yl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 88.0 [1], 240.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)isoindole-5-carboxamide | IC50 | 3200.0 [1], 4600.0 [2] |
 | N-[[1-(4-Fluoropiperidin-1-yl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 110.0 [1], 200.0 [2] |
 | N-[(1-Acetamidocyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 320.0 [1], 13000.0 [2] |
 | N-[(1-Morpholin-4-ylcycloheptyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 240.0 [1], 480.0 [2] |
 | N-[(1-Pyrrolidin-1-ylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 32.0 [1], 42.0 [2] |
 | N-[(1-Phenylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 810.0 [1], 4500.0 [2] |
 | N-(2-Chlorophenyl)-4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide | IC50 | 1000.0 [1], 4500.0 [2] |
 | N-Cyclohexyl-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 45.0 [1], 180.0 [2] |
 | 1,3-Dioxo-2-[(1S,2S)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 2500.0 [1] |
 | N-(2,6-Dichloro-4-cyanophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 62.0 [1], 120.0 [2] |
 | N-(3,5-Dichlorophenyl)-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 280.0 [1], 780.0 [2] |
 | N-Methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 1000.0 [1], 1600.0 [2] |
 | 1,3-Dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(4-phenylphenyl)-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxamide | IC50 | 890.0 [1], 2000.0 [2] |
 | N-[[1-(4-Methoxypiperidin-1-yl)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 210.0 [1], 530.0 [2] |
 | N-[(4-Ethylmorpholin-3-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | IC50 | 300.0 [1], 390.0 [2] |
 | 4-[3-(1-Methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]piperidine-1-carboxamide | IC50 | 19.0 [1], 21.0 [2] |
 | N-[(1-Piperidin-1-ylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide | IC50 | 8.0 [1], 10.0 [2] |
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