Sn1-specific diacylglycerol lipase alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Orlistat	IC50	1.0 [1], 10.0 [2], 60.0 [3], 1000.0 [4]
	(4-([1,1'-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone	IC50	6.31 [1], 125.89 [2], 2511.89 [3]
	2-[(2,2-Dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid	IC50	18.0 [1]
	2-[(2,2-Dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid	Ki	700.0 [1]
	[(2S)-2-Benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone	IC50	39.81 [1], 794.33 [2]
	[(2R)-2-Benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone	IC50	0.79 [1], 25.12 [2]
	1,6-Bis(cyclohexyloximinocarbonyl)hexane	IC50	60.0 [1], 65000.0 [2]
	2-[[(1R)-1-[4-(2,4-Dichlorophenyl)phenyl]ethyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid	IC50	19.0 [1], 100.0 [2]
	2-[3-(2,3-Dichlorophenyl)-N-[4-(difluoromethoxy)phenyl]sulfonylanilino]acetic acid	IC50	2.4 [1], 14.3 [2]
	2-[[3-(2,3-Dichlorophenyl)phenyl]methyl-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid	IC50	3.0 [1], 14.0 [2]
	2-[[4-(Difluoromethoxy)phenyl]sulfonyl-[[3-[2-(trifluoromethoxy)phenyl]phenyl]methyl]amino]acetic acid	IC50	17.0 [1], 60.0 [2]
	2-[[1-[3-(3,5-Dichlorophenyl)phenyl]cyclobutyl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid	IC50	0.6 [1], 37.0 [2]
	2-[[1-[4-(2,4-Dichlorophenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid	IC50	6.0 [1], 88.0 [2]
	2-[[4-(Difluoromethoxy)phenyl]sulfonyl-[1-[4-[2-(trifluoromethoxy)phenyl]phenyl]cyclobutyl]amino]acetic acid	IC50	8.0 [1], 82.0 [2]
	N,N-Dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide	IC50	10000.0 [1]
	1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one	IC50	37.15 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)-7-phenylheptan-1-one	IC50	524.81 [1]
	1-(Oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	Oleoyl oxazolopyridine	IC50	26.3 [1]
	7-Phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-[5-(Pyridin-2-Yl)-1,3,4-Oxadiazol-2-Yl]heptan-1-One	IC50	10000.0 [1]
	2-(7-Phenylheptanoyl)oxazole-5-carbonitrile	IC50	10000.0 [1]
	5-([1,1'-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide	IC50	510.0 [1]
	1-Oxazolo[4,5-B]pyridin-2-YL-1-dodecanone	IC50	30.9 [1]
	7-Phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-1-one	IC50	10000.0 [1]
	Orlistat derivative, 17c	IC50	2800.0 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-8-phenyloctan-1-one	IC50	46.77 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one	IC50	3.63 [1]
	7-Phenyl-1-(5-phenyl-1,3,4-oxadiazol-2-yl)heptan-1-one	IC50	10000.0 [1]
	Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate	IC50	10000.0 [1]
	1-(5-Methyl-2-oxazolyl)-7-phenyl-1-heptanone	IC50	10000.0 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)octan-1-one	IC50	630.96 [1]
	1-Benzooxazol-2-yl-6-phenyl-hexan-1-one	IC50	3630.78 [1]
	1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-4-phenylbutan-1-one	IC50	2238.72 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-5-phenylpentan-1-one	IC50	204.17 [1]
	CID 11991811	IC50	10000.0 [1]
	7-Phenyl-1-(5-(2,2,2-trifluoroacetyl)oxazol-2-yl)heptan-1-one	IC50	1819.7 [1]
	CID 11991890	IC50	10000.0 [1]
	N,N-Dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide	IC50	10000.0 [1]
	2-(7-Phenylheptanoyl)oxazole-5-carbaldehyde	IC50	10000.0 [1]
	1-(5-Bromooxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(5-Methylsulfanyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	[(2R,5R)-2-Benzyl-5-prop-2-ynoxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanone	IC50	1.26 [1]
	1-(5-(2-Fluorophenyl)oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(5-(3-Fluorophenyl)oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(5-(4-Fluorophenyl)oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(5-(4-Methoxyphenyl)oxazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)decan-1-one	IC50	74.13 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-1-oxo-pentane	IC50	10000.0 [1]
	7-Phenyl-1-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(2-(pyridin-2-yl)-2H-tetrazol-5-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(4H-1,2,4-triazol-3-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one	IC50	10000.0 [1]
	(5Z,8Z,11Z,14Z)-1-(Oxazolo[4,5-b]pyridin-2-yl)icosa-5,8,11,14-tetraen-1-one	IC50	2398.83 [1]
	5-[[(4-Azido-3-iodobenzoyl)amino]methyl]-N,N-dimethyltetrazole-1-carboxamide	IC50	130.0 [1]
	(2-Ethylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanone	IC50	63.1 [1]
	7-Phenyl-1-(5-pyridin-4-yl-[1,3,4]oxadiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-pyridin-3-yl-[1,3,4]oxadiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	Leucine orlistat, (-)-	IC50	5000.0 [1]
	7-Phenyl-1-(5-(4-(2,2,2-trifluoroacetyl)phenyl)oxazol-2-yl)heptan-1-one	IC50	10000.0 [1]
	CID 16110650	IC50	10000.0 [1]
	CID 16110720	IC50	10000.0 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)tetradecan-1-one	IC50	74.13 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)hexadecan-1-one	IC50	64.57 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)ethanone	IC50	10000.0 [1]
	1-(Oxazolo[4,5-b]pyridin-2-yl)-1-oxo-hexane	IC50	10000.0 [1]
	1-(5-(Furan-2-yl)-4H-1,2,4-triazol-3-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(2-(thiophen-2-yl)-2H-tetrazol-5-yl)-heptan-1-one	IC50	10000.0 [1]
	1-(1-Methyltetrazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	Methyl 3-(7-Phenylheptanoyl)-1,2,4-oxadiazole-5-carboxylate	IC50	10000.0 [1]
	Methyl 5-(7-Phenylheptanoyl)-4H-1,2,4-triazole-3-carboxylate	IC50	10000.0 [1]
	1-(3-(6-Chloropyridin-2-yl)-1,2,4-oxadiazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(3-(6-Bromopyridin-2-yl)-1,2,4-oxadiazol-5-yl)-7-phenylheptan-1-one	IC50	2041.74 [1]
	1-(3-(6-Iodopyridin-2-yl)-1,2,4-oxadiazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	6-[5-(7-Phenylheptanoyl)-1,2,4-oxadiazol-3-yl]pyridine-2-carbonitrile	IC50	1047.13 [1]
	7-Phenyl-1-(5-(pyridin-2-yl)-thiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-(thiophen-2-yl)-thiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	1-(5-(Furan-2-yl)-1,3,4-thiadiazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	Methyl 5-(7-Phenylheptanoyl)-1,3,4-thiadiazole-2-carboxylate	IC50	10000.0 [1]
	1-(6-(Furan-2-yl)-pyridazin-3-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)-heptan-1-one	IC50	10000.0 [1]
	1-(2-(Furan-2-yl)-2H-tetrazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(2-Methyl-2H-tetrazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one	IC50	2691.53 [1]
	1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)heptan-1-one	IC50	2754.23 [1]
	1-(3-(Furan-2-yl)-1,2,4-oxadiazol-5-yl)-7-phenylheptan-1-one	IC50	933.25 [1]
	7-Phenyl-1-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)-heptan-1-one	IC50	1949.84 [1]
	Methyl 6-(5-(7-Phenylheptanoyl)-1,2,4-oxadiazol-3-yl)-picolinate	IC50	10000.0 [1]
	6-(5-(7-Phenylheptanoyl)-1,2,4-oxadiazol-3-yl)-picolinic Acid	IC50	10000.0 [1]
	7-Phenyl-1-(5-(pyridin-2-yl)-1,2,4-oxadiazol-3-yl)-heptan-1-one	IC50	10000.0 [1]
	1-(5-(Furan-2-yl)-1,2,4-oxadiazol-3-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-heptan-1-one	IC50	10000.0 [1]
	1-(5-(Furan-2-yl)-thiazol-2-yl)-7-phenylheptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(5-(thiophen-2-yl)-1,3,4-thiadiazol-2-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one	IC50	10000.0 [1]
	7-Phenyl-1-(6-(pyridin-2-yl)-pyridazin-3-yl)-heptan-1-one	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sn1-specific diacylglycerol lipase alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/sn1-specific-diacylglycerol-lipase-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Sn1-specific diacylglycerol lipase alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sn1-specific-diacylglycerol-lipase-alpha-inhibitors-ic50-ki.
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