Sodium channel protein type I alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide	IC50	21000.0 [1], 100000.0 [2]
	N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamide	IC50	2550.0 [1], 8540.0 [2], 15300.0 [3]
	6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	400.0 [1], 10000.0 [2]
	2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide	IC50	20.0 [1], 32.0 [2]
	2-[(3-Methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one	IC50	4800.0 [1], 10000.0 [2]
	Tetrodotoxin	IC50	30.0 [1]
	Mexiletine hydrochloride	IC50	11000.0 [1]
	Senicapoc	IC50	1000.0 [1]
	CID 46840946	IC50	677.0 [1]
	Eleclazine	IC50	3400.0 [1]
	6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide	IC50	13000.0 [1]
	1-[2-Methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-2-oxo-N-pyrimidin-2-ylquinoline-6-sulfonamide	IC50	42500.0 [1]
	CID 91666633	IC50	45.0 [1]
	4-[4-Chloro-2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]phenoxy]-3-cyano-N-(1,3-thiazol-4-yl)benzenesulfonamide	IC50	10000.0 [1]
	5-Chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide	IC50	8750.0 [1]
	2-(4-(4-(Trifluoromethoxy)phenyl)-1H-imidazol-2-yl)propan-2-amine	IC50	11000.0 [1]
	4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	6380.0 [1]
	4-[2-(3-Amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	3080.0 [1]
	4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	216.0 [1]
	4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	3000.0 [1]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide	IC50	7300.0 [1]
	N-[6-Cyclopropyl-7-[(3,5-dichlorophenoxy)methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	112.0 [1]
	3-Cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	309.0 [1]
	1-[5-Fluoro-2-methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-N-(1,2-oxazol-3-yl)isoquinoline-6-sulfonamide	IC50	17000.0 [1]
	2-[1-[2-Hydroxy-3-[3-(trifluoromethyl)phenoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	1200.0 [1]
	2-[1-[2-Hydroxy-3-[4-(trifluoromethyl)phenoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	1800.0 [1]
	2-[1-[2-Hydroxy-3-[2-methoxy-4-(trifluoromethyl)phenoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	910.0 [1]
	2-[1-[2-Hydroxy-3-[[4-(trifluoromethyl)phenyl]methoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	3000.0 [1]
	N-[1-[2-Hydroxy-3-[4-(trifluoromethyl)phenoxy]propyl]piperidin-4-yl]benzamide	IC50	800.0 [1]
	1-[2-Hydroxy-3-[4-(trifluoromethyl)phenoxy]propyl]-N-phenylpiperidine-4-carboxamide	IC50	3100.0 [1]
	1-[2-Hydroxy-3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]propyl]-N-phenylpiperidine-4-carboxamide	IC50	3300.0 [1]
	8-[4-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperazin-1-yl]-4H-1,4-benzoxazin-3-one	IC50	33000.0 [1]
	8-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-4H-1,4-benzoxazin-3-one	IC50	4400.0 [1]
	5-[4-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one	IC50	21000.0 [1]
	5-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one	IC50	7100.0 [1]
	7-[4-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperazin-1-yl]-3H-1,3-benzoxazol-2-one	IC50	33000.0 [1]
	4-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-1,4-benzoxazin-3-one	IC50	4800.0 [1]
	3-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-1,3-benzoxazol-2-one	IC50	5400.0 [1]
	1-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-3H-indol-2-one	IC50	26000.0 [1]
	2-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	3300.0 [1]
	N-[1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]benzamide	IC50	3200.0 [1]
	1-[3-(2-Benzoylphenoxy)-2-hydroxypropyl]-N-phenylpiperidine-4-carboxamide	IC50	4300.0 [1]
	2-[1-[3-(3-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	920.0 [1]
	2-[1-[3-(4-Benzoylphenoxy)-2-hydroxypropyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	670.0 [1]
	2-[1-(2-Hydroxy-3-phenoxypropyl)piperidin-4-yl]-3H-isoindol-1-one	IC50	8000.0 [1]
	2-[1-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	19000.0 [1]
	2-[1-[2-Hydroxy-3-(3-methoxyphenoxy)propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	3000.0 [1]
	2-[1-[2-Hydroxy-3-(4-methoxyphenoxy)propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	2700.0 [1]
	2-[1-[2-Hydroxy-3-[2-(trifluoromethyl)phenoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	4500.0 [1]
	1H-Pyrazole-5-carboxamide, N-(6-amino-5-(2-chloro-5-methoxyphenyl)-2-pyridinyl)-1-methyl-	IC50	37000.0 [1]
	N-[7-(1-Adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	53.0 [1]
	2-[1-[2-Hydroxy-3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]propyl]piperidin-4-yl]-3H-isoindol-1-one	IC50	1500.0 [1]
	4-[[3-Chloro-4-(trifluoromethoxy)phenyl]methoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	455.0 [1]
	N-[[3-Chloro-4-(trifluoromethoxy)phenyl]methyl]-3-fluoro-4-(1,2,4-thiadiazol-5-ylsulfamoyl)benzamide	IC50	12.0 [1]
	N-[[3-Chloro-4-(trifluoromethoxy)phenyl]methyl]-3-fluoro-4-(1,3-thiazol-2-ylsulfamoyl)benzamide	IC50	20.0 [1]
	3-[[5-[4-(Trifluoromethoxy)phenyl]-1H-imidazol-2-yl]methyl]oxetan-3-amine	IC50	43000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 56 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sodium channel protein type I alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-i-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Sodium channel protein type I alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-i-alpha-subunit-inhibitors-ic50-ki.
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