Sodium channel protein type II alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide	IC50	7180.0 [1], 7380.0 [2], 7400.0 [3], 9490.0 [4]
	Phenytoin	IC50	100000.0 [1]
	Phenytoin	Ki	53370.0 [1]
	Lamotrigine	IC50	10000.0 [1], 17000.0 [2], 100000.0 [3]
	N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide	IC50	29000.0 [1], 46000.0 [2], 71000.0 [3]
	N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamide	IC50	3540.0 [1], 24100.0 [2], 65000.0 [3]
	Tetracaine	IC50	490.0 [1], 1100.0 [2]
	6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	400.0 [1], 7900.0 [2]
	2,4-Diphenylimidazole	IC50	40600.0 [1]
	2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide	IC50	240.0 [1], 393.0 [2]
	6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide	IC50	12800.0 [1], 14000.0 [2]
	2-[(3-Methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one	IC50	4200.0 [1], 8100.0 [2]
	Tetrodotoxin	IC50	30.0 [1]
	Amitriptyline	IC50	3100.0 [1]
	Riluzole	IC50	2200.0 [1]
	Mexiletine	IC50	2900.0 [1]
	Senicapoc	IC50	1000.0 [1]
	Sipatrigine	IC50	2550.0 [1]
	CID 46840946	IC50	119.0 [1]
	Eleclazine	IC50	10100.0 [1]
	2-(1,2-Dihydroacenaphthylen-5-yl)-1-(4-methoxynaphthalen-1-yl)guanidine	IC50	1310.0 [1]
	[(3R,5S,6S,11R,12S,16S)-14,17-Diamino-19,19-dihydroxy-6-(hydroxymethyl)-10-oxo-3-sulfooxy-8-oxa-1,9,13,15,18-pentazapentacyclo[9.5.2.13,16.05,9.012,16]nonadeca-14,17-dien-13-yl]methyl N-hydroxycarbamate	IC50	0.01 [1]
	2-Phenyl-4-[3-(trifluoromethyl)phenyl]-1H-imidazole	IC50	2700.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,57-bis(4-aminobutyl)-21-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-24-(3-amino-3-oxopropyl)-54,74-bis(3-carbamimidamidopropyl)-13,51-bis(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36,68-tris(1H-indol-3-ylmethyl)-71-(2-methylpropyl)-7,33-bis(2-methylsulfanylethyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-4-propan-2-yl-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid	IC50	41.0 [1]
	2-(4-Methoxyphenyl)-4-phenyl-1H-imidazole	IC50	21400.0 [1]
	N-(4-Carboxyphenyl)phthalimide	Ki	50400.0 [1]
	N-(2-Carboxyphenyl)Phthalimide	Ki	337800.0 [1]
	4-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide	Ki	16010.0 [1]
	2-(4-Chlorophenyl)-5-phenyl-1H-imidazole	IC50	1400.0 [1]
	4-(3-Chlorophenyl)-2-phenyl-1H-imidazole	IC50	17900.0 [1]
	2-[4-(Trifluoromethyl)phenyl]-4-phenyl-1H-imidazole	IC50	10100.0 [1]
	2-(4-Chlorophenyl)-5-[3-(trifluoromethyl)phenyl]-1H-imidazole	IC50	100000.0 [1]
	2-(Oxan-4-yl)-3-oxo-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide	IC50	33000.0 [1]
	2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1H-imidazole	IC50	1400.0 [1]
	2,5-Bis[3-(trifluoromethyl)phenyl]-1H-imidazole	IC50	200.0 [1]
	CID 91666633	IC50	7.0 [1]
	1-Benzyl-7-chloro-N-pentylquinolin-4(1H)-imine	IC50	2200.0 [1]
	N-[(2-Morpholin-4-ylpyridin-3-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]pyrazine-2-carboxamide	IC50	1500.0 [1]
	(3S,4R,5R)-3-N-Cyclopropyl-5-N-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-3-N-(5-propan-2-ylpyridin-2-yl)piperidine-3,5-dicarboxamide	IC50	30000.0 [1]
	N-[6-Amino-5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl]-3-methyl-1,2-oxazole-4-carboxamide	IC50	10000.0 [1]
	2-(4-Nitrophenyl)-5-[3-(trifluoromethyl)phenyl]-1H-imidazole	IC50	2500.0 [1]
	4-[4-Chloro-2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]phenoxy]-3-cyano-N-(1,3-thiazol-4-yl)benzenesulfonamide	IC50	2044.0 [1]
	5-Chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide	IC50	398.0 [1]
	Unii-403N302X2Y	IC50	33000.0 [1]
	2-(4-(4-(Trifluoromethoxy)phenyl)-1H-imidazol-2-yl)propan-2-amine	IC50	16000.0 [1]
	4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	0.2 [1]
	4-[2-(3-Amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	4.2 [1]
	4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	149.0 [1]
	4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	276.0 [1]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide	IC50	2100.0 [1]
	1H-Isoindole-1,3(2H)-dione, 2-(2-nitrophenyl)-	Ki	133560.0 [1]
	N-(4-Nitrophenyl)phthalimide	Ki	65560.0 [1]
	4-Butoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	630.0 [1]
	1-Butyl-2-(4-methylbenzoyl)guanidine	IC50	17350.0 [1]
	1-[3-(Dimethylamino)propyl]-2-(4-methylbenzoyl)guanidine	IC50	25000.0 [1]
	N-[6-Cyclopropyl-7-[(3,5-dichlorophenoxy)methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	10.0 [1]
	1-Benzyl-2-(4-methylbenzoyl)guanidine	IC50	3870.0 [1]
	1-[Amino(4-methylbenzoylimino)methyl]indoline	IC50	8810.0 [1]
	N-[6-Amino-5-(2,3,5-trichlorophenyl)pyridin-2-yl]acetamide	IC50	3500.0 [1]
	3-Cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	2.52 [1]
	1-[1-(2-Fluorophenyl)indazol-4-yl]-3-[2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]imidazolidin-2-one	IC50	4000.0 [1]
	(3Ar,6aS)-5-[1-(2-fluorophenyl)indazol-4-yl]-2-(3-hydroxy-3-methylbutanoyl)-3,3a,6,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-4-one	IC50	20000.0 [1]
	1-[2-[5-Fluoro-1-(2-fluorophenyl)indazol-3-yl]oxyethyl]imidazolidin-2-one	IC50	2600.0 [1]
	1-(4-Tert-Butylphenyl)-2-(4-methylbenzoyl)guanidine	IC50	24000.0 [1]
	1-[4-(Benzyloxy)phenyl]-2-(4-methylbenzoyl)guanidine	IC50	10090.0 [1]
	1-(4-Isopropylphenyl)-2-(4-methylbenzoyl)guanidine	IC50	1950.0 [1]
	4-Methyl-N-(N'-naphthalen-1-ylcarbamimidoyl)benzamide	IC50	3290.0 [1]
	4-Methyl-N-[N'-(2-propan-2-ylphenyl)carbamimidoyl]benzamide	IC50	4360.0 [1]
	N-[N'-(2,5-Dibromophenyl)carbamimidoyl]-4-methylbenzamide	IC50	25000.0 [1]
	4-Methyl-N-[N'-(3,4,5-trimethoxyphenyl)carbamimidoyl]benzamide	IC50	1920.0 [1]
	4-Methyl-N-[N'-(4-propan-2-yloxyphenyl)carbamimidoyl]benzamide	IC50	2020.0 [1]
	4-[(2R,3R)-3-(3,5-Dichlorophenyl)-6,6-dimethylmorpholin-2-yl]oxy-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	1500.0 [1]
	5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide	IC50	2800.0 [1]
	4-Methyl-N-[N'-(2-phenoxyethyl)carbamimidoyl]benzamide	IC50	3230.0 [1]
	3,4,5-Trimethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	1390.0 [1]
	4-Methyl-N-[N'-(3-phenylpropyl)carbamimidoyl]benzamide	IC50	6030.0 [1]
	4-Methyl-N-[N'-(3-phenoxypropyl)carbamimidoyl]benzamide	IC50	2670.0 [1]
	N-[N'-[2-(4-Chlorophenyl)ethyl]carbamimidoyl]-4-methylbenzamide	IC50	1970.0 [1]
	4-Methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]benzamide	IC50	2380.0 [1]
	4-Methyl-N-[N'-(2-phenylethyl)carbamimidoyl]benzamide	IC50	2660.0 [1]
	N-[N'-(4-Phenylbutyl)carbamimidoyl]thiophene-2-carboxamide	IC50	4310.0 [1]
	2-Methyl-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	1200.0 [1]
	2,5-Dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	3250.0 [1]
	N-[Amino-(3-iodo-N-methylanilino)methylidene]-4-methylbenzamide	IC50	9450.0 [1]
	4-Ethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	760.0 [1]
	N-[N'-(4-Phenylbutyl)carbamimidoyl]naphthalene-1-carboxamide	IC50	860.0 [1]
	N-[Amino-[7-(trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]methylidene]-4-methylbenzamide	IC50	25000.0 [1]
	N-[N'-(2-Benzylsulfanylethyl)carbamimidoyl]-4-methylbenzamide	IC50	3900.0 [1]
	4-Methyl-N-[N'-(5-phenylpentyl)carbamimidoyl]benzamide	IC50	2110.0 [1]
	4-Chloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	4300.0 [1]
	2,6-Dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	5030.0 [1]
	2,3-Dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	1480.0 [1]
	4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoic acid	Ki	78420.0 [1]
	[5-(4-Tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpiperazin-1-yl)-methanone	IC50	100.0 [1]
	1-[5-(4-Chlorophenyl)-2-furoyl]piperazine	IC50	1100.0 [1]
	2-(3-Nitrophenyl)isoindole-1,3-dione	Ki	21800.0 [1]
	N-[N'-[2-(5-Methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide	IC50	1760.0 [1]
	3,4-Dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide	IC50	7110.0 [1]
	N-((1E)-Amino{methyl[(3-methylphenyl)thio]amino}methylene)-4-methylbenzamide	IC50	5440.0 [1]
	N-[N'-[2-(4-Methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide	IC50	3350.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sodium channel protein type II alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-ii-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Sodium channel protein type II alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-ii-alpha-subunit-inhibitors-ic50-ki.
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