Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-(1-Adamantylmethoxy)-5-chloro-2-fluoro-N-methylsulfonylbenzamide	IC50	40.0 [1]
	Tetracaine	IC50	200.0 [1]
	Tetracaine	Ki	500.0 [1], 12000.0 [2]
	N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide	IC50	170.0 [1], 500.0 [2], 3300.0 [3], 3600.0 [4]
	N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide	Ki	35.0 [1], 400.0 [2], 10000.0 [3]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide	IC50	160.0 [1]
	CID 46840946	IC50	11.0 [1]
	3-Cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide	IC50	28.0 [1]
	N-[7-(1-Adamantylmethoxy)-6-chloro-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	20.0 [1], 150.0 [2], 6130.0 [3], 7330.0 [4], 30690.0 [5]
	Mexiletine	IC50	11000.0 [1], 56000.0 [2], 340000.0 [3], 56000000.0 [4]
	Mexiletine	Ki	13000.0 [1]
	Tert-butyl N-[(2R)-1-oxo-1-[[(3R)-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamate	IC50	35.0 [1]
	Tert-butyl N-[(2R)-1-oxo-1-[[(3R)-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamate	Ki	40.0 [1]
	1-[2-Methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-2-oxo-N-pyrimidin-2-ylquinoline-6-sulfonamide	IC50	5.0 [1], 6.0 [2], 20.0 [3], 21.0 [4], 23.0 [5]
	N-(Azetidin-1-ylsulfonyl)-4-[(5-chloro-2-adamantyl)oxy]-5-cyclopropyl-2-fluorobenzamide	IC50	9.0 [1], 10.0 [2], 30.0 [3], 94.0 [4]
	(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,57-bis(4-aminobutyl)-21-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-24-(3-amino-3-oxopropyl)-54,74-bis(3-carbamimidamidopropyl)-13,51-bis(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36,68-tris(1H-indol-3-ylmethyl)-71-(2-methylpropyl)-7,33-bis(2-methylsulfanylethyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-4-propan-2-yl-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid	IC50	0.3 [1], 1.0 [2], 3.0 [3]
	4-(2'-(Trifluoromethoxy)biphenyl-3-yl)thiazole-2-carboxamide	IC50	15.0 [1], 230.0 [2]
	4-(2'-(Trifluoromethoxy)biphenyl-3-yl)thiazole-2-carboxamide	Ki	15.0 [1], 230.0 [2]
	CID 118734437	IC50	13.2 [1], 27.0 [2], 630.0 [3]
	[3-(Dimethylamino)-4-methoxyphenyl]-(7-methoxyspiro[5H-pyrrolo[1,2-a]quinoxaline-4,4'-piperidine]-1'-yl)methanone	IC50	9.0 [1], 331.0 [2]
	(2S)-N-[6-[4-(4-Fluorophenoxy)phenyl]pyridin-2-yl]-3-(1H-imidazol-5-yl)-2-(methanesulfonamido)propanamide	IC50	140.0 [1]
	(2S)-N-[6-[4-(4-Fluorophenoxy)phenyl]pyridin-2-yl]-3-(1H-imidazol-5-yl)-2-(methanesulfonamido)propanamide	Ki	19.0 [1]
	4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	0.3 [1], 30.0 [2]
	4-[2-(3-Amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	0.4 [1], 0.6 [2]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	64.0 [1], 120.0 [2], 124.0 [3]
	4-[(4-Aminocyclohexyl)methylamino]-5-chloro-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamide	IC50	4.0 [1], 6.0 [2], 398.0 [3], 9400.0 [4]
	6-[[(2S)-1-Amino-1-oxopropan-2-yl]amino]-2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide	IC50	180.0 [1]
	6-[[(2S)-1-Amino-1-oxopropan-2-yl]amino]-2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide	Ki	16.0 [1]
	(2R,3S)-3-[6-[4-[3-Cyano-4-(trifluoromethyl)phenoxy]phenyl]pyridin-2-yl]-2,3-dihydroxypropanamide	IC50	244.0 [1]
	(2R,3S)-3-[6-[4-[3-Cyano-4-(trifluoromethyl)phenoxy]phenyl]pyridin-2-yl]-2,3-dihydroxypropanamide	Ki	347.0 [1]
	2-[4-(4-Fluorophenoxy)phenyl]-6-methyl-N-[2-(1-methylpiperidin-1-ium-1-yl)ethyl]pyridine-4-carboxamide	IC50	872.0 [1]
	2-[4-(4-Fluorophenoxy)phenyl]-6-methyl-N-[2-(1-methylpiperidin-1-ium-1-yl)ethyl]pyridine-4-carboxamide	Ki	6030.0 [1], 6033.0 [2]
	6-Chloro-4-[2-cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	20.0 [1], 21.3 [2], 373.0 [3], 390.0 [4]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-6-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	9.86 [1], 37.0 [2], 140.0 [3], 183.0 [4]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	16.0 [1], 21.0 [2], 90.0 [3], 91.4 [4]
	N-(Azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluoro-4-[(4-methylcyclohexyl)methoxy]benzamide	IC50	6.0 [1], 7.0 [2], 87.0 [3], 280.0 [4]
	4-[(5-Chloro-2-adamantyl)oxy]-5-cyclopropyl-2-fluoro-N-(3-fluoroazetidin-1-yl)sulfonylbenzamide	IC50	20.0 [1], 28.0 [2], 890.0 [3], 1200.0 [4]
	N-(Azetidin-1-ylsulfonyl)-5-chloro-2-fluoro-4-[(5-methoxy-2-adamantyl)oxy]benzamide	IC50	300.0 [1], 390.0 [2], 1400.0 [3], 3600.0 [4]
	N-(Azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluoro-4-[(5-fluoro-2-adamantyl)oxy]benzamide	IC50	20.0 [1], 21.0 [2], 24.0 [3], 100.0 [4]
	Tetrodotoxin	IC50	6.0 [1], 25.0 [2], 30.0 [3]
	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide	IC50	6740.0 [1], 35340.0 [2]
	4-Amino-2-[(4-tert-butylphenyl)methylsulfanyl]-1H-pyrimidin-6-one	IC50	340.0 [1], 680.0 [2], 2200.0 [3]
	6-Amino-2-heptylthiopyrimidin-4-ol	IC50	400.0 [1], 940.0 [2], 1400.0 [3]
	(1R,2R)-1-N-Methyl-1-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamide	IC50	830.0 [1]
	(1R,2R)-1-N-Methyl-1-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamide	Ki	250.0 [1], 290.0 [2]
	N-[[4-(2-Sulfamoylphenyl)phenyl]methyl]-N'-[(5-thiophen-2-ylthiophen-2-yl)methyl]butanediamide	IC50	150.0 [1]
	N-[[4-(2-Sulfamoylphenyl)phenyl]methyl]-N'-[(5-thiophen-2-ylthiophen-2-yl)methyl]butanediamide	Ki	150.0 [1]
	4-[[(3S,4R)-4-(4-Chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	2.0 [1], 3.3 [2], 59.0 [3]
	CID 91666633	IC50	3.0 [1], 7.0 [2], 10.0 [3]
	4-(1-Adamantylmethoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide	IC50	0.4 [1], 2.0 [2]
	CID 118734430	IC50	10.0 [1], 90.0 [2]
	CID 118734436	IC50	27.0 [1], 270.0 [2]
	CID 118734482	IC50	4.0 [1], 7.0 [2]
	CID 118734547	IC50	8.0 [1], 90.0 [2]
	N-Me-aminopyrimidinone 9	IC50	80.0 [1], 420.0 [2], 500.0 [3]
	{2-[2-(4-Chloro-phenyl)-thiazol-4-ylmethoxy]-phenyl}-pyrrolidin-1-yl-methanone	IC50	1000.0 [1]
	{2-[2-(4-Chloro-phenyl)-thiazol-4-ylmethoxy]-phenyl}-pyrrolidin-1-yl-methanone	Ki	160.0 [1]
	N-[6-Cyclopropyl-7-[(3,5-dichlorophenoxy)methyl]-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	1.0 [1], 2.0 [2], 20.0 [3]
	1-[1-(2-Fluorophenyl)indazol-4-yl]-3-[2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]imidazolidin-2-one	IC50	370.0 [1], 480.0 [2], 570.0 [3]
	1-[5-Fluoro-2-methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-N-(1,2-oxazol-3-yl)isoquinoline-6-sulfonamide	IC50	17.0 [1], 36.0 [2], 4000.0 [3]
	2-N-[4-(4-Chlorophenoxy)phenyl]-1,3,5-triazine-2,4-diamine	IC50	300.0 [1], 2200.0 [2], 2900.0 [3]
	N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide	IC50	14500.0 [1], 28000.0 [2], 37000.0 [3]
	N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamide	IC50	3020.0 [1], 4820.0 [2], 5640.0 [3]
	2-N-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]pyrazine-2,6-diamine	IC50	240.0 [1], 800.0 [2], 3000.0 [3]
	4-[[4-(7-Benzyl-5,6-dimethylpyrrolo[2,3-d]pyrimidin-4-yl)oxypiperidin-1-yl]methyl]-1,3-thiazole	IC50	60.0 [1], 150.0 [2], 6400.0 [3]
	N-Pyrimidin-4-yl-5-[2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]naphthalene-2-sulfonamide	IC50	30.0 [1], 90.0 [2]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,2-oxazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	3640.0 [1], 9200.0 [2], 9210.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-pyrimidin-4-yl-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	28.5 [1], 460.0 [2], 464.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-oxazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	924.0 [1], 2590.0 [2], 2600.0 [3]
	4-[2-Chloro-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	7.83 [1], 38.6 [2]
	5-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-1H-isoquinoline-2-sulfonamide	IC50	22.1 [1], 30.0 [2]
	N-[5-Chloro-6-[(3,4-dichlorophenoxy)methyl]-1,2-benzoxazol-3-yl]methanesulfonamide	IC50	6.0 [1], 150.0 [2], 5600.0 [3]
	N-[5-Chloro-6-[(3,4-dichlorophenyl)methoxy]-1,2-benzoxazol-3-yl]methanesulfonamide	IC50	74.0 [1], 1270.0 [2], 74000.0 [3]
	N-[7-(1-Adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanesulfonamide	IC50	3.0 [1], 10.0 [2], 12.0 [3]
	1-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)isoquinoline-6-sulfonamide	IC50	10.0 [1], 298.0 [2], 300.0 [3]
	1-[4-(3-Fluorophenyl)-2-methoxyphenyl]-N-pyrimidin-4-ylisoquinoline-6-sulfonamide	IC50	20.0 [1], 150.0 [2], 156.0 [3]
	8-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-1,7-naphthyridine-3-sulfonamide	IC50	160.0 [1], 2500.0 [2], 2530.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	15.0 [1], 190.0 [2], 193.0 [3]
	4-(4-Cyano-2-methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	7.5 [1], 175.0 [2], 250.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-5-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	193.0 [1], 1990.0 [2], 2000.0 [3]
	4-(4-Fluoro-2-methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	17.0 [1], 192.0 [2], 280.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-8-fluoro-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	34.0 [1], 516.0 [2], 520.0 [3]
	N-Pyrimidin-4-yl-4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl]-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	6.2 [1], 135.0 [2], 140.0 [3]
	4-(2-Methoxyphenyl)-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	38.0 [1], 380.0 [2], 382.0 [3]
	4-[2-Cyano-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-4-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	1630.0 [1], 2780.0 [2], 2800.0 [3]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-3-oxo-N-(1,3-thiazol-2-yl)-1,4-benzoxazine-7-sulfonamide	IC50	12.0 [1], 210.0 [2], 218.0 [3]
	5-Chloro-2-fluoro-N-methylsulfonyl-4-[[4-(trifluoromethyl)cyclohexyl]methoxy]benzamide	IC50	84.7 [1], 86.0 [2], 158.0 [3]
	5-Cyclopropyl-2-fluoro-N-methylsulfonyl-4-[[4-(trifluoromethyl)cyclohexyl]methoxy]benzamide	IC50	7.0 [1], 13.0 [2]
	Carbamazepine	IC50	22000.0 [1]
	Carbamazepine	Ki	32700.0 [1]
	Amitriptyline	IC50	1000.0 [1], 7000.0 [2]
	Safinamide	IC50	33000.0 [1], 100000.0 [2]
	Eleclazine	IC50	1100.0 [1], 5200.0 [2]
	N-(2-Morpholin-4-ylphenyl)-2-quinolin-8-yloxyacetamide	IC50	31.0 [1], 10000.0 [2]
	2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide	IC50	5200.0 [1], 10000.0 [2]
	6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide	IC50	14000.0 [1], 19000.0 [2]
	CID 11998198	IC50	3.0 [1]
	N-[(2R)-1-[[(3R)-7-Chloro-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-(2-fluorophenyl)-1-oxopropan-2-yl]-4-fluoro-2-(trifluoromethyl)benzamide	IC50	30.0 [1]
	Sodium Channel inhibitor 1	IC50	87.0 [1], 280.0 [2]
	CID 118734434	IC50	100.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-ix-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Sodium channel protein type IX alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-ix-alpha-subunit-inhibitors-ic50-ki.
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