Sodium channel protein type V alpha subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	250.0 [1], 333.0 [2], 3000.0 [3], 10000.0 [4]
	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide	IC50	2000.0 [1], 7340.0 [2], 7440.0 [3], 32820.0 [4]
	3-Cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide	IC50	10000.0 [1], 30000.0 [2]
	[3-(Dimethylamino)-4-methoxyphenyl]-(7-methoxyspiro[5H-pyrrolo[1,2-a]quinoxaline-4,4'-piperidine]-1'-yl)methanone	IC50	351.0 [1], 572.0 [2], 10485.0 [3]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide	IC50	16000.0 [1], 30000.0 [2]
	5-Chloro-2-fluoro-4-[(4-hydroxycyclohexyl)methylamino]-N-(1,3-thiazol-2-yl)benzenesulfonamide	IC50	156.0 [1], 380.0 [2], 730.0 [3], 1300.0 [4]
	2-[(3-Methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one	IC50	1330.0 [1], 1900.0 [2], 10000.0 [3]
	Lamotrigine	IC50	39810.72 [1], 62000.0 [2], 100000.0 [3]
	Tetracaine	IC50	200.0 [1], 530.0 [2], 650.0 [3]
	Propafenone	IC50	1190.0 [1], 3300.0 [2], 5000.0 [3]
	Mexiletine	IC50	13000.0 [1], 58000.0 [2], 420000.0 [3]
	Dofetilide	IC50	300000.0 [1], 316227.77 [2], 630957.34 [3]
	CID 46840946	IC50	11.0 [1], 10000.0 [2], 25000.0 [3]
	N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide	IC50	1100.0 [1], 5200.0 [2], 10000.0 [3]
	Nav1.7-IN-3	IC50	2.2 [1], 30000.0 [2]
	CID 118734430	IC50	5000.0 [1], 10000.0 [2]
	CID 118734436	IC50	5000.0 [1], 10000.0 [2]
	CID 118734482	IC50	400.0 [1], 2300.0 [2]
	CID 118734547	IC50	5000.0 [1], 8800.0 [2]
	4-(1-Adamantylmethoxy)-5-chloro-2-fluoro-N-methylsulfonylbenzamide	IC50	1070.0 [1], 1900.0 [2]
	4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzoxazine-7-sulfonamide	IC50	1990.0 [1], 2000.0 [2]
	2-N-[4-(4-Chlorophenoxy)phenyl]-1,3,5-triazine-2,4-diamine	IC50	200.0 [1], 3200.0 [2], 10000.0 [3]
	N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide	IC50	19000.0 [1], 69000.0 [2], 100000.0 [3]
	N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamide	IC50	920.0 [1], 14800.0 [2], 36000.0 [3]
	2-N-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]pyrazine-2,6-diamine	IC50	1260.0 [1], 1500.0 [2], 10000.0 [3]
	Phenytoin	IC50	49000.0 [1], 100000.0 [2]
	Sildenafil	IC50	501187.23 [1], 1258925.41 [2]
	Quinidine	IC50	6900.0 [1], 16600.0 [2]
	Moxifloxacin	IC50	39810.72 [1], 251188.64 [2]
	Everolimus	IC50	199526.23 [1], 630957.34 [2]
	Sunitinib	IC50	15848.93 [1], 39810.72 [2]
	Dasatinib	IC50	100000.0 [1], 398107.17 [2]
	Duloxetine	IC50	7943.28 [1], 15848.93 [2]
	Nelfinavir	IC50	79432.82 [1], 501187.23 [2]
	Tadalafil	IC50	125892.54 [1], 158489.32 [2]
	Sitagliptin	IC50	630957.34 [1], 794328.23 [2]
	Nilotinib	IC50	1000000.0 [1], 5011872.34 [2]
	Raltegravir	IC50	316227.77 [1], 1584893.19 [2]
	Darunavir	IC50	39810.72 [1], 100000.0 [2]
	Vardenafil	IC50	199526.23 [1], 2511886.43 [2]
	Tolterodine	IC50	6309.57 [1], 31622.78 [2]
	Nebivolol	IC50	6309.57 [1], 7943.28 [2]
	Maraviroc	IC50	630957.34 [1], 1000000.0 [2]
	Deferasirox	IC50	79432.82 [1], 501187.23 [2]
	Paliperidone	IC50	25118.86 [1], 158489.32 [2]
	Etravirine	IC50	501187.23 [1], 3981071.71 [2]
	Alfuzosin	IC50	199526.23 [1], 1584893.19 [2]
	Eltrombopag	IC50	158489.32 [1], 316227.77 [2]
	Ambrisentan	IC50	1000000.0 [1], 1258925.41 [2]
	Desvenlafaxine	IC50	199526.23 [1], 316227.77 [2]
	Oliceridine	IC50	4700.0 [1], 16500.0 [2]
	F-15845 Free base	IC50	2560.0 [1], 5770.0 [2]
	3-(2-Aminopropoxy)-2,4-dimethylphenol	IC50	30000.0 [1], 174000.0 [2]
	Auglurant	IC50	100000.0 [1]
	2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide	IC50	9200.0 [1], 10000.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,57-bis(4-aminobutyl)-21-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-24-(3-amino-3-oxopropyl)-54,74-bis(3-carbamimidamidopropyl)-13,51-bis(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36,68-tris(1H-indol-3-ylmethyl)-71-(2-methylpropyl)-7,33-bis(2-methylsulfanylethyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-4-propan-2-yl-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid	IC50	79.0 [1], 90.0 [2]
	2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]acetamide	IC50	30000.0 [1]
	1-[2-Methoxy-4-[3-(trifluoromethyl)phenyl]phenyl]-2-oxo-N-pyrimidin-2-ylquinoline-6-sulfonamide	IC50	30000.0 [1], 42500.0 [2]
	4-[[(3S,4R)-4-(4-Chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	10000.0 [1]
	CID 118734434	IC50	5000.0 [1]
	CID 118734437	IC50	27000.0 [1]
	CID 118734438	IC50	5000.0 [1]
	CID 118734439	IC50	5000.0 [1]
	CID 118734440	IC50	5000.0 [1]
	CID 118734441	IC50	5000.0 [1]
	CID 118734442	IC50	5000.0 [1]
	CID 118734443	IC50	5000.0 [1]
	CID 118734444	IC50	5000.0 [1]
	CID 118734445	IC50	5000.0 [1]
	CID 118734446	IC50	20000.0 [1]
	CID 118734447	IC50	20000.0 [1]
	CID 118734448	IC50	5000.0 [1]
	CID 118734449	IC50	20000.0 [1]
	CID 118734450	IC50	5000.0 [1]
	CID 118734451	IC50	4700.0 [1]
	CID 118734452	IC50	5000.0 [1]
	CID 118734456	IC50	5000.0 [1]
	CID 118734458	IC50	5000.0 [1]
	CID 118734459	IC50	5000.0 [1]
	CID 118734460	IC50	5000.0 [1]
	CID 118734461	IC50	5000.0 [1]
	CID 118734489	IC50	500.0 [1], 3500.0 [2]
	CID 118734490	IC50	5000.0 [1], 10000.0 [2]
	CID 118734548	IC50	5000.0 [1], 10000.0 [2]
	1-[2-[3-(4-Benzhydrylpiperazin-1-yl)-2-hydroxypropoxy]-5-fluorophenyl]-3-phenylpropan-1-one	IC50	5000.0 [1]
	1-[2-[2-Hydroxy-3-[4-(4-methylphenyl)piperazin-1-yl]propoxy]phenyl]-3-phenylpropan-1-one	IC50	5000.0 [1]
	Unii-403N302X2Y	IC50	12589.25 [1], 13000.0 [2]
	(6S)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide	IC50	30000.0 [1]
	1-Methyl-3-[2-(2-methylpyrazol-3-yl)-4-(trifluoromethyl)phenyl]-N-(1,2,4-thiadiazol-5-yl)indole-6-sulfonamide	IC50	10000.0 [1], 30000.0 [2]
	4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	10000.0 [1]
	4-[2-(3-Amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	1000.0 [1], 1380.0 [2]
	(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide	IC50	30000.0 [1]
	Tert-butyl 2-amino-4-[3-(1H-indole-2-carbonylamino)phenyl]imidazole-1-carboxylate	IC50	30000.0 [1]
	3-Cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	IC50	2000.0 [1], 12797.25 [2]
	1-[2-Methoxy-4-(trifluoromethyl)phenyl]-2-oxo-N-(1,3-thiazol-2-yl)quinoline-6-sulfonamide	IC50	30000.0 [1]
	CID 127045799	IC50	5000.0 [1], 10000.0 [2]
	CID 127045811	IC50	5000.0 [1], 10000.0 [2]
	CID 127046243	IC50	5000.0 [1], 10000.0 [2]
	CID 127046252	IC50	5000.0 [1], 15900.0 [2]
	CID 127046253	IC50	1000.0 [1], 3500.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sodium channel protein type V alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-v-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Sodium channel protein type V alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-v-alpha-subunit-inhibitors-ic50-ki.
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