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Sodium channel protein type X alpha subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC508.0 [1]
N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamideIC5028000.0 [1], 100000.0 [2]
N-[[5-[2-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]-3-(trifluoromethoxy)benzamideIC503770.0 [1], 5660.0 [2], 6340.0 [3]
LamotrigineIC5096000.0 [1], 98000.0 [2]
2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamideIC503000.0 [1], 10000.0 [2]
6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamideIC50190.0 [1], 2600.0 [2]
N-[(2-Morpholin-4-ylpyridin-3-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]pyrazine-2-carboxamideIC5019.0 [1], 30.0 [2]
N-[6-Amino-5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl]-3-methyl-1,2-oxazole-4-carboxamideIC50260.0 [1], 530.0 [2]
N-(3,5-Dimethylphenyl)-6-[4-(trifluoromethoxy)phenyl]pyrazine-2-carboxamideIC5021.0 [1]
1H-Pyrazole-5-carboxamide, N-(6-amino-5-(2-chloro-5-methoxyphenyl)-2-pyridinyl)-1-methyl-IC50190.0 [1], 700.0 [2]
TetrodotoxinIC5030.0 [1]
MexiletineIC5056000.0 [1]
CID 46840946IC5010000.0 [1]
EleclazineIC501500.0 [1]
(1R,2R)-1-N-Methyl-1-N-[[4-(2-sulfamoylphenyl)phenyl]methyl]-2-N-[[4-(trifluoromethoxy)phenyl]methyl]cyclopentane-1,2-dicarboxamideKi180.0 [1]
CID 118734430IC5012200.0 [1]
5-(4-Chlorophenyl)-N-[(2R)-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-1-oxopropan-2-yl]furan-2-carboxamideIC501000.0 [1]
4-[4-Chloro-2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]phenoxy]-3-cyano-N-(1,3-thiazol-4-yl)benzenesulfonamideIC5010000.0 [1]
5-Chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamideIC5030000.0 [1]
2-(4-(4-(Trifluoromethoxy)phenyl)-1H-imidazol-2-yl)propan-2-amineIC5053.0 [1]
4-[2-(2-Amino-3H-benzimidazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC503850.0 [1]
4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC503000.0 [1]
4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC5010000.0 [1]
4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamideIC5030000.0 [1]
N-[6-Amino-5-(2,3,5-trichlorophenyl)pyridin-2-yl]acetamideIC50160.0 [1]
3-Cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamideIC5010000.0 [1]
6-Amino-5-(2-chlorophenyl)-N-methylpyridine-2-carboxamideIC5032000.0 [1]
6-Amino-5-(3-chlorophenyl)-N-methylpyridine-2-carboxamideIC5032000.0 [1]
6-Amino-5-(4-chlorophenyl)-N-methylpyridine-2-carboxamideIC5032000.0 [1]
6-Amino-5-(2,5-dichlorophenyl)-N-methylpyridine-2-carboxamideIC5012000.0 [1]
6-Amino-5-(3,5-dichlorophenyl)-N-methylpyridine-2-carboxamideIC5032000.0 [1]
N-[6-Amino-5-(5-chloro-2-methoxyphenyl)pyridin-2-yl]-2-methylpyrazole-3-carboxamideIC507400.0 [1]
N-[6-Amino-5-(2-chloro-5-methoxyphenyl)pyridin-2-yl]-2-methylpropanamideIC504000.0 [1]
(4S)-4-[[(2S)-6-Amino-2-[[(2S)-5-carbamimidamido-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,51,74-tris(4-aminobutyl)-24-(3-amino-3-oxopropyl)-21-[[(2S)-2-[[(2S)-2-aminopent-4-ynoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-68-[(5-bromo-1H-indol-3-yl)methyl]-33-butyl-4,54-bis(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36-bis(1H-indol-3-ylmethyl)-57-methyl-7,71-bis(2-methylpropyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]pentanoyl]amino]hexanoyl]amino]-5-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC50509.0 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-65-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-27,74-bis(4-aminobutyl)-24-(3-amino-3-oxopropyl)-68-[(5-bromo-1H-indol-3-yl)methyl]-33-butyl-4,54-bis(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36-bis(1H-indol-3-ylmethyl)-51,57-dimethyl-7,71-bis(2-methylpropyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontan-21-yl]amino]-1-oxopent-4-yn-2-yl]amino]-5-oxopentanoic acidIC501000.0 [1]
(4S)-4-[[(2S)-6-Amino-2-[[(2S)-5-carbamimidamido-2-[[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,51S,54S,57S,60R,65R,68S,71S,74S)-27,51,74-tris(4-aminobutyl)-24-(3-amino-3-oxopropyl)-21-[[(2S)-2-[[(2S)-2-aminopent-4-ynoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-33-butyl-4,54-bis(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-45-(carboxymethyl)-39-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-30,36,68-tris(1H-indol-3-ylmethyl)-57-methyl-7,71-bis(2-methylpropyl)-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,67,70,73,76,81-tricosaoxo-18,19,62,63,78,79-hexathia-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,66,69,72,75,82-tricosazatricyclo[40.34.4.216,60]dooctacontane-65-carbonyl]amino]pentanoyl]amino]hexanoyl]amino]-5-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC501000.0 [1]
5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamideIC503.0 [1]
5-(4-Cyanophenyl)-N-(3-methylphenyl)furan-2-carboxamideIC5079.0 [1]
[5-(4-Tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpiperazin-1-yl)-methanoneIC5030.0 [1]
1-[5-(4-Chlorophenyl)-2-furoyl]piperazineIC50280.0 [1]
Tert-butyl N-[(2R)-1-[(3-benzylimidazo[4,5-b]pyridin-2-yl)methylamino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]carbamateIC50270.0 [1]
N-[6-Amino-5-(2,5-dichlorophenyl)pyridin-2-yl]-2-methylpyrazole-3-carboxamideIC50920.0 [1]
N-[6-Amino-5-(2,3,5-trichlorophenyl)pyridin-2-yl]-2-methylpyrazole-3-carboxamideIC50750.0 [1]
N-[6-Amino-5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl]-2-methylpyrazole-3-carboxamideIC502400.0 [1]
N-[6-Amino-5-(2,3,5-trichlorophenyl)pyridin-2-yl]-3-methyl-1,2-oxazole-4-carboxamideIC50670.0 [1]
N-[6-Amino-5-(2-chloro-5-methoxyphenyl)pyridin-2-yl]-3-methyl-1,2-oxazole-4-carboxamideIC50500.0 [1]
N-[6-Amino-5-(2-chlorophenyl)pyridin-2-yl]-2-methylpyrazole-3-carboxamideIC504900.0 [1]
[(3S,5S,6S,8S,10S,13S,14S,17S)-6-[(2R,3R,4S,5R,6R)-3,5-Dihydroxy-4-[(2S,3R,4S,5R)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-4-hydroxy-6-methyl-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-5-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfateIC509000.0 [1]
Tert-butyl N-[(2R)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-[2-(trifluoromethyl)phenyl]propan-2-yl]carbamateIC50793.0 [1]
N-[(2R)-1-[(3-Benzylimidazo[4,5-b]pyridin-2-yl)methylamino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2,2-dimethylpropanamideIC501458.0 [1]
N-[(2R)-1-[(3-Benzylimidazo[4,5-b]pyridin-2-yl)methylamino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-3,3-dimethylbutanamideIC50361.0 [1]
N-[(2R)-1-[(3-Benzylimidazo[4,5-b]pyridin-2-yl)methylamino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-(trifluoromethoxy)benzamideIC50230.0 [1]
N-[(2R)-1-[(3-Benzylimidazo[4,5-b]pyridin-2-yl)methylamino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-(trifluoromethyl)benzamideIC50366.0 [1]
1-Methyl-N-[(2R)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-[2-(trifluoromethyl)phenyl]propan-2-yl]cyclopropane-1-carboxamideIC502975.0 [1]
N-[(2R)-1-Oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-1-(trifluoromethyl)cyclopropane-1-carboxamideIC501782.0 [1]
N-[(2R)-1-Oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-(trifluoromethoxy)benzamideIC50825.0 [1]
Tert-butyl N-[(2R)-3-(2-fluorophenyl)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC50880.0 [1]
Tert-butyl N-[(2R)-3-(2-chlorophenyl)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC50500.0 [1]
Tert-butyl N-[(2R)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamateIC50985.0 [1]
Tert-butyl N-[(2R)-3-(2,6-difluorophenyl)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC50685.0 [1]
Tert-butyl N-[(2R)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-(2,3,6-trifluorophenyl)propan-2-yl]carbamateIC50446.0 [1]
Tert-butyl N-[(2R)-3-(2-chloro-5-fluorophenyl)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC50295.0 [1]
Tert-butyl N-[(2R)-3-[3-fluoro-2-(trifluoromethyl)phenyl]-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC50806.0 [1]
Tert-butyl N-[(2R)-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]carbamateIC501242.0 [1]
N-[(2R)-3-(2,6-Difluorophenyl)-1-oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]propan-2-yl]-1-(trifluoromethyl)cyclopropane-1-carboxamideIC501869.0 [1]
N-[(2R)-1-Oxo-1-[[3-(1-phenylcyclopropyl)imidazo[4,5-b]pyridin-2-yl]methylamino]-3-(2,3,6-trifluorophenyl)propan-2-yl]-1-(trifluoromethyl)cyclopropane-1-carboxamideIC50446.0 [1]
[5-(4-Chlorophenyl)furan-2-yl]-(4-cyclohexylpiperazin-1-yl)-methanoneIC50300.0 [1]
N-Benzyl-5-(4-chlorophenyl)nicotinamideIC5022.0 [1]
5-(4-Chlorophenyl)-N-[(2-piperidin-1-ylpyridin-3-yl)methyl]pyridine-3-carboxamideIC5014.0 [1]
CID 50899643IC5023.0 [1]
1-[3-[2,5-Bis(trifluoromethyl)phenyl]phenyl]pyrazole-3,5-dicarboxamideIC502000000.0 [1]
1-[3-[2-(Trifluoromethyl)phenyl]phenyl]pyrazole-3,5-dicarboxamideIC50915.0 [1]
N-(3,5-Dimethylphenyl)-6-(4-ethoxyphenyl)pyrazine-2-carboxamideIC502.0 [1]
N-(3,5-Dimethylphenyl)-5-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamideIC5026.0 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethylphenyl)pyridine-3-carboxamideIC509.0 [1]
5-(4-Chlorophenyl)-N-[(2-chloropyridin-3-yl)methyl]pyridine-3-carboxamideIC50140.0 [1]
6-(4-Chlorophenyl)-N-[(2-pyrrolidin-1-ylpyridin-3-yl)methyl]pyrazine-2-carboxamideIC5030.0 [1]
6-(4-Chlorophenyl)-N-[(2-methylphenyl)methyl]pyrazine-2-carboxamideIC5027.0 [1]
6-(4-Chlorophenyl)-N-(3-methylphenyl)pyrazine-2-carboxamideIC506.0 [1]
N-(3,5-Dimethylphenyl)-5-(4-fluorophenyl)pyridine-3-carboxamideIC50100.0 [1]
6-(4-Cyanophenyl)-N-(3,5-dimethylphenyl)pyrazine-2-carboxamideIC508.0 [1]
N-(3,5-Dimethylphenyl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole-5-carboxamideIC50470.0 [1]
N-(3,5-Dimethylphenyl)-5-[4-(trifluoromethoxy)phenyl]-1,2,4-thiadiazole-3-carboxamideIC508.0 [1]
6-(4-Ethoxyphenyl)-N-[(2-methylphenyl)methyl]pyrazine-2-carboxamideIC502.0 [1]
6-(4-Chlorophenyl)-N-(3,5-dimethylphenyl)pyrazine-2-carboxamideIC503.0 [1]
N-(3,5-Dimethylphenyl)-6-[4-(trifluoromethoxy)phenyl]pyridine-2-carboxamideIC5064.0 [1]
5-(4-Chlorophenyl)-N-[(2-morpholin-4-ylphenyl)methyl]pyridine-3-carboxamideIC5010.0 [1]
5-(4-Chlorophenyl)-N-[(2-ethoxypyridin-3-yl)methyl]pyridine-3-carboxamideIC507.0 [1]
5-(4-Chlorophenyl)-N-(2-methylbenzyl)nicotinamideIC502.0 [1]
N-(3-Methylphenyl)-6-[4-(trifluoromethoxy)phenyl]pyrazine-2-carboxamideIC505.0 [1]
N-(3,5-Dimethylphenyl)-5-[4-(trifluoromethoxy)phenyl]furan-2-carboxamideIC502.0 [1]
N-(3,5-Dimethylphenyl)-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxamideIC5051.0 [1]
N-[(2-Methylphenyl)methyl]-6-[4-(trifluoromethoxy)phenyl]pyrazine-2-carboxamideIC5018.0 [1]
6-(4-Cyanophenyl)-N-(3-propan-2-yloxyphenyl)pyrazine-2-carboxamideIC5049.0 [1]
6-(4-Ethoxyphenyl)-N-(3-methylphenyl)pyrazine-2-carboxamideIC501.0 [1]
6-(4-Cyanophenyl)-N-[(2-methylphenyl)methyl]pyrazine-2-carboxamideIC50150.0 [1]
5-(4-Chlorophenyl)-N-[(2-piperidin-1-ylphenyl)methyl]pyridine-3-carboxamideIC508.0 [1]
N-(2-Chlorobenzyl)-5-(4-chlorophenyl)nicotinamideIC504.0 [1]
6-(4-Chlorophenyl)-N-[(3-morpholin-4-ylpyridin-4-yl)methyl]pyrazine-2-carboxamideIC50320.0 [1]
6-(4-Chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]pyrazine-2-carboxamideIC5019.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sodium channel protein type X alpha subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/sodium-channel-protein-type-x-alpha-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Sodium channel protein type X alpha subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sodium-channel-protein-type-x-alpha-subunit-inhibitors-ic50-ki.
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