Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Quercetin	IC50	12000.0 [1]
	Myricetin	IC50	12000.0 [1]
	(3S,4S,5S)-5-(Fluoromethyl)-2-(hydroxymethyl)oxolane-2,3,4-triol	Ki	916000.0 [1], 6210000.0 [2]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	1-Cyclopentyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	2000.0 [1]
	1-(5-Fluoro-2-methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	880.0 [1]
	1-(3,5-Difluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	6-[4-(2-Methoxyphenyl)piperazin-1-yl]-9-phenylpurine	IC50	3500.0 [1]
	1-(2-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	1200.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-b]pyridine	IC50	600.0 [1]
	4-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile	IC50	10000.0 [1]
	6-[4-(2-Methoxyphenyl)piperazin-1-yl]-9-phenyl-7H-purin-8-one	IC50	10000.0 [1]
	1-(3-Fluoropyridin-2-yl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	7000.0 [1]
	1-(3-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	900.0 [1]
	4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidin-1-yl]benzonitrile	IC50	10000.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[4,3-c]pyridine	IC50	5000.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(1-phenylethyl)pyrazolo[3,4-d]pyrimidine	IC50	2100.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-3-ylpyrazolo[3,4-d]pyrimidine	IC50	6000.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-4-ylpyrazolo[3,4-d]pyrimidine	IC50	4400.0 [1]
	2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile	IC50	5990.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-7-phenylpyrazolo[3,4-d]triazine	IC50	10000.0 [1]
	1-Phenyl-4-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(3-Fluorophenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	1210.0 [1]
	3-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile	IC50	220.0 [1]
	4-[4-(2-Fluoro-6-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	1200.0 [1]
	4-[4-(2-Methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	1360.0 [1]
	1-Phenyl-4-[4-[2-(trifluoromethoxy)phenyl]piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(3-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	2-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile	IC50	10000.0 [1]
	4-[4-(4-Methoxypyridin-3-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	510.0 [1]
	4-[4-(3-Methoxypyridin-2-yl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	950.0 [1]
	2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]cyclohexan-1-ol	IC50	10000.0 [1]
	4-[4-(2-Methoxyphenyl)piperidin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(2-Methoxyphenyl)-3-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	1400.0 [1]
	4-[4-(2-Methoxyphenyl)-2-methylpiperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	2500.0 [1]
	4-[(1S,4S)-5-(2-Methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[(1R,4R)-5-(2-Methoxyphenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine	IC50	1480.0 [1]
	1-(4-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine	IC50	2600.0 [1]
	4-[4-(2-Methoxyphenyl)piperazino]-1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(2-Fluorophenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine	IC50	1120.0 [1]
	4-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyrimidine	IC50	1000.0 [1]
	4-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine	IC50	8700.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-pyridin-2-ylpyrazolo[3,4-d]pyrimidine	IC50	8000.0 [1]
	4-[4-(5-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	7-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-phenyltriazolo[4,5-d]pyrimidine	IC50	3300.0 [1]
	2-[4-(1-Phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]phenol	IC50	60.0 [1]
	1-(3-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[4-(2-Methoxyphenyl)-1,4-diazepan-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	21.0 [1]
	1-(2-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine	IC50	1100.0 [1]
	4-Methoxy-3-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzamide	IC50	100.0 [1]
	3-Methoxy-4-[4-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]benzonitrile	IC50	1700.0 [1]
	4-[4-(4-Fluoro-2-methoxyphenyl)piperazin-1-yl]-1-phenylpyrazolo[3,4-d]pyrimidine	IC50	10000.0 [1]
	4-[[2-(4-Chlorophenyl)-6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine	IC50	100000.0 [1]
	2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]benzonitrile	IC50	6.0 [1]
	[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(4-methoxyphenyl)methanone	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-N-(3-fluorophenyl)piperazine-1-carboxamide	IC50	100000.0 [1]
	4-[[2-(4-Chlorophenyl)-6-(2,6-difluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]morpholine	IC50	6.0 [1]
	[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(oxetan-3-yl)methanone	IC50	6.0 [1]
	1-[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]ethanone	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-propan-2-ylimidazo[1,2-a]pyrazin-3-yl]methyl]morpholine	IC50	6.0 [1]
	2-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]benzonitrile	IC50	6.0 [1]
	2-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]benzonitrile	IC50	6.0 [1]
	1-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-1,4-diazepan-5-one	IC50	6.0 [1]
	1-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]-4-methyl-1,4-diazepan-5-one	IC50	6.0 [1]
	2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-3-fluorobenzonitrile	IC50	6.0 [1]
	2-[2-(4-Chlorophenyl)-3-[(4-methyl-3-oxopiperazin-1-yl)methyl]imidazo[1,2-a]pyridin-6-yl]benzonitrile	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-(2,6-difluorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]morpholine	IC50	6.0 [1]
	N-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamide	IC50	10000.0 [1]
	1-[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]propan-1-one	IC50	6.0 [1]
	2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyridin-6-yl]pyridine-3-carbonitrile	IC50	10000.0 [1]
	[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(oxan-4-yl)methanone	IC50	10000.0 [1]
	N-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]methanesulfonamide	IC50	10000.0 [1]
	7-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine	IC50	6.0 [1]
	[4-[[2-(4-Chlorophenyl)-6-cyclopropylimidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyridin-4-ylmethanone	IC50	6.0 [1]
	2-[2-(4-Chlorophenyl)-3-(morpholin-4-ylmethyl)imidazo[1,2-a]pyrazin-6-yl]benzonitrile	IC50	10000.0 [1]
	1-[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]ethanone	IC50	6.0 [1]
	4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-2-one	IC50	6.0 [1]
	[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyrazin-2-ylmethanone	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-(1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-one	IC50	10000.0 [1]
	N-[3-[(4-Acetylpiperazin-1-yl)methyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamide	IC50	10000.0 [1]
	1-[4-[[2-(4-Chlorophenyl)-6-(1,1-dioxo-1,2-thiazolidin-2-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-2-methoxyethanone	IC50	6.0 [1]
	1-[4-[[2-(4-Chlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]ethanone	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-one	IC50	6.0 [1]
	[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-pyridazin-4-ylmethanone	IC50	6.0 [1]
	7-[[2-(2,4-Dichlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridin-3-yl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazine	IC50	6.0 [1]
	[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-(oxan-4-yl)methanone	IC50	6.0 [1]
	N-[2-(4-Chlorophenyl)-3-(piperazin-1-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamide	IC50	100000.0 [1]
	Ethyl 2-[2-(4-chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]acetate	IC50	10000.0 [1]
	4-[[2-(2,4-Dichlorophenyl)-6-(1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-2-one	IC50	6.0 [1]
	4-[[2-(4-Chlorophenyl)-6-(oxetan-3-yl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine	IC50	100000.0 [1]
	2-[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]-1-morpholin-4-ylethanone	IC50	10000.0 [1]
	[4-[[6-Cyclopropyl-2-(2,4-dichlorophenyl)imidazo[1,2-a]pyrazin-3-yl]methyl]piperazin-1-yl]-(1,3-thiazol-4-yl)methanone	IC50	6.0 [1]
	N-[2-(4-Chlorophenyl)-3-[[4-(2-methoxyacetyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamide	IC50	10000.0 [1]
	1-[4-[[2-(4-Chlorophenyl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-2-hydroxy-2-methylpropan-1-one	IC50	6.0 [1]
	4-[[2-(Oxan-4-yl)-6-phenylimidazo[1,2-a]pyridin-3-yl]methyl]morpholine	IC50	100000.0 [1]
	N-[2-(4-Chlorophenyl)-3-[[4-(oxetane-3-carbonyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]-N-methylmethanesulfonamide	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/solute-carrier-family-2-facilitated-glucose-transporter-member-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Solute carrier family 2, facilitated glucose transporter member 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/solute-carrier-family-2-facilitated-glucose-transporter-member-2-inhibitors-ic50-ki.
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