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Sorbitol dehydrogenase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-[2-(Hydroxymethyl)pyrimidin-4-YL]-N,N-dimethylpiperazine-1-sulfonamideIC50240.0 [1], 246.0 [2], 1000.0 [3]
QuercetinIC5035600.0 [1], 177000.0 [2]
1-(4-{4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-yl]-2,6-dimethyl-piperazin-1-yl}-pyrimidin-2-yl)-ethanolIC5010.0 [1], 33.0 [2]
[4-(4-Isoquinolin-1-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC50150.0 [1], 430.0 [2]
[4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC50120.0 [1], 410.0 [2]
[4-(4-Benzooxazol-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC50190.0 [1], 740.0 [2]
4-[4-(4,6-Dimethyl-2-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5093.0 [1], 350.0 [2]
{4-[4-(2,6-Dimethyl-pyrimidin-4-yl)-piperazin-1-yl]-pyrimidin-2-yl}-methanolIC50140.0 [1], 480.0 [2]
{4-[4-(2-Hydroxymethyl-pyrimidin-4-yl)-piperazin-1-yl]-pyrimidin-2-yl}-methanolIC50260.0 [1], 1100.0 [2]
4-[4-(1,2-Benzisothiazole-3-yl)piperazino]pyrimidine-2-methanolIC5064.0 [1], 330.0 [2]
2-Pyrimidinemethanol, 4-[4-(2-quinolinyl)-1-piperazinyl]-IC5087.0 [1], 590.0 [2]
CoumarinIC50400000.0 [1]
4-MethylumbelliferoneIC50153000.0 [1]
UmbelliferoneIC50120000.0 [1]
ScopoletinIC50137000.0 [1]
EsculetinIC5082900.0 [1]
4-HydroxycoumarinIC50400000.0 [1]
EpalrestatIC5067700.0 [1]
7-MethoxycoumarinIC50124000.0 [1]
3-HydroxycoumarinIC50106000.0 [1]
4-MethylesculetinIC50212000.0 [1]
IsoscopoletinIC50250000.0 [1]
6-HydroxycoumarinIC50400000.0 [1]
7-Hydroxycoumarin-4-acetic acidIC50163000.0 [1]
7-Hydroxy-4-phenylcoumarinIC5070700.0 [1]
(1R)-1-[4-[(3S,5R)-4-[2-[(1R)-1-Hydroxyethyl]pyrimidin-4-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5010.0 [1]
NordalberginIC50288000.0 [1]
Unii-4Q45inj6TQIC505.0 [1]
(1R)-1-[4-[(3S,5R)-4-[4-(Hydroxymethyl)-6-methylpyrimidin-2-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC50130.0 [1]
(1R)-1-[4-[(2R,6S)-4-[2-(2,4-Dimethylimidazol-1-yl)pyrimidin-4-yl]-2,6-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC504.0 [1]
1-{4-[4-(4-Hydroxymethyl-6-methyl-pyrimidin-2-yl)-3-methyl-piperazin-1-yl]-pyrimidin-2-yl}-ethanolIC5080.0 [1]
1-[4-[(2R,6S)-4-[2-[(1R)-1-Hydroxyethyl]pyrimidin-4-yl]-2,6-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanoneIC506.0 [1]
(1R)-1-[4-[(2R,6S)-4-[4-(Hydroxymethyl)-6-methylpyrimidin-2-yl]-2,6-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC50100.0 [1]
(1R)-1-[4-[(2R,6S)-2,6-Dimethyl-4-[2-(4-methylimidazol-1-yl)pyrimidin-4-yl]piperazin-1-yl]pyrimidin-2-yl]ethanolIC5013.0 [1]
1-{4-[2,6-Dimethyl-4-(4-phenyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-ethanolIC507.0 [1]
1-[4-[(3S,5R)-4-(2-Acetylpyrimidin-4-yl)-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanoneIC50212.0 [1]
(1R)-1-[4-[(2S,6R)-2,6-Dimethyl-4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]piperazin-1-yl]pyrimidin-2-yl]ethanolIC504.0 [1]
[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC501100.0 [1]
(R)-alpha-Methyl-4-[4-(4-phenyl-2-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5067.0 [1]
(R)-alpha-Methyl-4-[4-(oxazolo[5,4-b]pyridine-2-yl)piperazino]pyrimidine-2-methanolIC5032.0 [1]
[4-(4-Phenyl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC509400.0 [1]
(1R)-1-[4-[(2R,6S)-2,6-Dimethyl-4-([1,3]oxazolo[5,4-c]pyridin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC50270.0 [1]
[4-(4-Pyrimidin-4-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC502300.0 [1]
[4-(4-Pyrazin-2-ylpiperazin-1-yl)pyrimidin-2-yl]methanolIC501300.0 [1]
1-[4-(2,6-Dimethyl-4-quinoxalin-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-ethanolIC50180.0 [1]
(1R)-1-[4-[(2S,6R)-2,6-Dimethyl-4-(4-methyl-6-phenyl-1,3,5-triazin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC5043.0 [1]
(R)-alpha-Methyl-4-[4-(oxazolo[5,4-c]pyridine-2-yl)piperazino]pyrimidine-2-methanolIC5024.0 [1]
[4-[4-(4,6-Dichloro-1,3,5-triazin-2-yl)piperazin-1-yl]pyrimidin-2-yl]methanolIC50490.0 [1]
(1R)-1-[4-[4-([1,3]Oxazolo[4,5-b]pyridin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC50170.0 [1]
1-{4-[4-(4-Hydroxymethyl-6-methyl-pyrimidin-2-yl)-2-methyl-piperazin-1-yl]-pyrimidin-2-yl}-ethanolIC50170.0 [1]
(1R)-1-[4-[(3R)-4-[4-(Hydroxymethyl)-6-methylpyrimidin-2-yl]-3-methylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC50140.0 [1]
[4-[4-(1,3,5-Triazin-2-yl)piperazin-1-yl]pyrimidin-2-yl]methanolIC502600.0 [1]
[4-[4-(1-Ethylbenzimidazol-2-yl)piperazin-1-yl]pyrimidin-2-yl]methanolIC504800.0 [1]
(R)-alpha-Methyl-4-[4-(1,2-benzisothiazole-3-yl)piperazino]pyrimidine-2-methanolIC5012.0 [1]
1-[4-(3-Methyl-4-oxazolo[5,4-c]pyridin-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-ethanolIC5023.0 [1]
(1R)-1-[4-[4-[4,6-Bis(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]pyrimidin-2-yl]ethanolIC50190.0 [1]
(R)-alpha-Methyl-4-[4-(quinoxaline-2-yl)piperazino]pyrimidine-2-methanolIC5036.0 [1]
(R)-alpha-Methyl-4-[4-(4,6-diethyl-2-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5080.0 [1]
[4-[4-(1,1-Dioxo-1,2-benzothiazol-3-yl)piperazin-1-yl]pyrimidin-2-yl]methanolIC503200.0 [1]
(R)-alpha-Methyl-4-[4-(benzoxazole-2-yl)piperazino]pyrimidine-2-methanolIC5035.0 [1]
(1R)-1-[4-[(2S)-4-[4-(Hydroxymethyl)-6-methylpyrimidin-2-yl]-2-methylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC50200.0 [1]
(1R)-1-[4-[4-(4-Methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC50110.0 [1]
(R)-alpha-Methyl-4-[4-(2,6-dimethyl-4-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5031.0 [1]
4-[2-[(1S)-1-Methoxyethyl]pyrimidin-4-yl]-N,N-dimethylpiperazine-1-sulfonamideIC50486.0 [1]
(R)-alpha-Methyl-4-[4-(3-methylquinoxaline-2-yl)piperazino]pyrimidine-2-methanolIC508.0 [1]
(1R)-1-[4-[4-(4-Methyl-6-phenylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC50220.0 [1]
4-[2-(1-Hydroxyethyl)pyrimidin-4-yl]-N,N-dimethylpiperazine-1-sulfonamideIC50173.0 [1]
(R)-alpha-Methyl-4-[4-(isoquinoline-1-yl)piperazino]pyrimidine-2-methanolIC5034.0 [1]
(R)-alpha-Methyl-4-[4-(4,6-diisopropyl-2-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5072.0 [1]
(R)-alpha-Methyl-4-[4-(4,6-dimethyl-2-pyrimidinyl)piperazino]pyrimidine-2-methanolIC5023.0 [1]
(R)-alpha-Methyl-4-[4-(oxazolo[4,5-c]pyridine-2-yl)piperazino]pyrimidine-2-methanolIC5080.0 [1]
[4-(4-Benzothiazol-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC503200.0 [1]
{4-[4-(1H-Benzoimidazol-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-methanolIC506500.0 [1]
(R)-alpha-Methyl-4-[4-[4-(hydroxymethyl)-6-methyl-2-pyrimidinyl]piperazino]pyrimidine-2-methanolIC5020.0 [1]
[4-(4-Pyridin-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC503000.0 [1]
(R)-alpha-Methyl-4-[4-(quinoline-2-yl)piperazino]pyrimidine-2-methanolIC5044.0 [1]
(1R)-1-[4-[4-(6,7-Dichloroquinoxalin-2-yl)piperazin-1-yl]pyrimidin-2-yl]ethanolIC50120.0 [1]
[4-(4-Quinazolin-4-yl-piperazin-1-yl)-pyrimidin-2-yl]-methanolIC50890.0 [1]
(R)-alpha-Methyl-4-[4-(1,2-benzisoxazole-3-yl)piperazino]pyrimidine-2-methanolIC5037.0 [1]
1-[4-[(3S,5R)-4-[2-[(1R)-1-Hydroxyethyl]pyrimidin-4-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanoneIC5019.0 [1]
1-[4-[(3S,5R)-4-[2-(1-Hydroxyethyl)pyrimidin-4-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5028.0 [1]
(1S)-1-[4-[(3S,5R)-4-[2-[(1S)-1-Hydroxyethyl]pyrimidin-4-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC50831.0 [1]
(1R)-1-[4-[4-[2-(2-Hydroxyethyl)pyrimidin-4-yl]piperazin-1-yl]pyrimidin-2-yl]ethanolIC5040.0 [1]
(1R)-1-[4-[(2R)-4-[2-(2-Hydroxyethyl)pyrimidin-4-yl]-2-methylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5012.0 [1]
(1R)-1-[4-[(2S)-4-[2-(2-Hydroxyethyl)pyrimidin-4-yl]-2-methylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5059.0 [1]
(1R)-1-[4-[(2R,6S)-4-[2-(2-Hydroxyethyl)pyrimidin-4-yl]-2,6-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5010.0 [1]
6,7-Dihydroxycoumarin-4-acetic AcidIC50335000.0 [1]
(1R)-1-[4-[(3S,5R)-4-[2-[(1S)-1-Hydroxyethyl]pyrimidin-4-yl]-3,5-dimethylpiperazin-1-yl]pyrimidin-2-yl]ethanolIC5019.0 [1]
1-{4-[2,6-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-ethanolIC507.0 [1]
1-[4-(3-Methyl-4-quinoxalin-2-yl-piperazin-1-yl)-pyrimidin-2-yl]-ethanolIC5099.0 [1]
4-[2-[(1R)-1-Hydroxyethyl]pyrimidin-4-yl]-N,N-dimethylpiperazine-1-sulfonamideIC5027.0 [1]
Items per page: 1 - 10 of 91
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sorbitol dehydrogenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/sorbitol-dehydrogenase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Sorbitol dehydrogenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sorbitol-dehydrogenase-inhibitors-ic50-ki.
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