Sphingosine 1-phosphate receptor Edg-1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sphingosine 1-phosphate	IC50	0.16 [1], 0.47 [2], 0.67 [3], 0.78 [4], 1.4 [5]
	FTY720 phosphate	IC50	0.01 [1], 0.28 [2]
\n\n	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	1.2 [1]
	Merck SIP Agonist	IC50	0.6 [1]
	3-(Tetradecylamino)propylphosphonic acid	IC50	2.3 [1], 3.7 [2]
	[(1R,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	0.1 [1], 4.8 [2]
	[3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid	IC50	0.2 [1], 0.6 [2], 3.1 [3]
	5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole	IC50	37.0 [1]
	Fingolimod phosphate ester, S-	IC50	0.28 [1], 2.1 [2]
	(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid	Ki	18.0 [1], 77.0 [2]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	362.0 [1]
	[(3S)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]phosphonic acid	Ki	2840.0 [1], 4630.0 [2]
	4-Amino-6-(4-octylphenyl)hexanoic Acid	IC50	710.0 [1]
	3-(3-Bromo-5-methoxy-4-(octyloxy)benzylamino)propylphosphonic acid	IC50	4.1 [1]
	3-Amino-5-(4-octylphenyl)pentanoic Acid	IC50	1900.0 [1]
	[3-(4-Octyl-benzylamino)-propyl]-phosphonic acid	IC50	0.2 [1], 0.6 [2]
	[2-Amino-4-(4-octylphenyl)butyl] dihydrogen phosphate	IC50	0.76 [1]
	Phosphonic acid, [3-amino-5-(4-octylphenyl)pentyl]-	IC50	8.4 [1]
	[3-Amino-3-hydroxymethyl-5-(4-octyl-phenyl)-pentyl]-phosphonic acid	IC50	6.0 [1], 8.7 [2]
	1-(4-Nonylbenzyl)pyrrolidin-3-ylphosphonic acid	IC50	0.33 [1], 6.9 [2]
	1-{4-[5-(4-Tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}azetidine-3-carboxylic acid	IC50	100.0 [1]
	(S)-2-Amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate	IC50	1.05 [1]
	1-{4-[3-(4-Tert-butylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}azetidine-3-carboxylic acid	IC50	8.2 [1]
	(R)-2-Amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate	IC50	1.03 [1]
	1-[[4-[[3-(Trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	1060.0 [1]
	(2S)-2-[[4-[3-[(4-Chloro-2,5-dimethylphenyl)sulfonylamino]phenyl]-2,6-dimethylbenzoyl]amino]propanoic acid	IC50	2.6 [1]
	6-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]-1H-benzimidazol-2-amine	IC50	10000.0 [1]
	(2S,4R)-N-[4-(4-Fluorophenoxy)phenyl]-4-[(4-fluorophenyl)methyl]-1-[2-(triazol-2-yl)acetyl]pyrrolidine-2-carboxamide	IC50	4.8 [1], 21.0 [2]
	(2S,4R)-N-[4-(4-Fluorophenoxy)phenyl]-4-[(4-fluorophenyl)methyl]-1-[2-(triazol-1-yl)acetyl]pyrrolidine-2-carboxamide	IC50	5.8 [1], 26.0 [2]
	N-Methyl-N-[2-oxo-2-[[1-oxo-1-(4-phenoxyanilino)-3-phenylmethoxypropan-2-yl]amino]ethyl]benzamide	IC50	718.0 [1], 2800.0 [2]
	(2S,4R)-4-Benzyl-N-[4-(4-fluorophenoxy)phenyl]-1-[2-(1,2,4-triazol-1-yl)acetyl]pyrrolidine-2-carboxamide	IC50	6.8 [1], 45.0 [2]
	(2S,4R)-N-[4-(4-Fluorophenoxy)phenyl]-4-[(4-fluorophenyl)methyl]-1-[2-(1,2,4-triazol-1-yl)acetyl]pyrrolidine-2-carboxamide	IC50	5.8 [1], 13.0 [2]
	4-(5-(2-(1-(3,5-Difluorophenyl)cyclohexyl)ethyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one	IC50	13.0 [1]
	(2S)-N-[4-(4-Fluorophenoxy)phenyl]-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-phenylmethoxypropanamide	IC50	13.0 [1], 284.0 [2]
	1-[(2-Methyl-4-phenylmethoxyphenyl)methyl]azetidine-3-carboxylic acid	IC50	4170.0 [1]
	(2S)-N-[4-(4-Chlorophenoxy)phenyl]-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-phenylmethoxypropanamide	IC50	32.0 [1], 221.0 [2]
	2-(4-Butoxyphenyl)sulfanyl-5-[2-(1-hydroxytridec-2-ynyl)phenyl]benzenesulfonic acid	IC50	190.0 [1], 1000.0 [2]
	2-(4-Butoxyphenyl)sulfanyl-5-[2-[1-hydroxy-4-(7-hydroxyheptoxy)but-2-ynyl]phenyl]benzenesulfonic acid	IC50	31.0 [1], 500.0 [2]
	Fingolimod	IC50	840.0 [1]
	CID 10223146	IC50	1000.0 [1]
	Ponesimod	IC50	12.59 [1]
	Etrasimod	IC50	1.88 [1]
	Ceralifimod	Ki	0.63 [1]
	N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide	IC50	6400.0 [1]
	CID 59393720	IC50	2.0 [1]
	(2R)-2-Amino-2-[(phosphonooxy)methyl]-4-(4-octylphenyl)-1-butanol	IC50	0.16 [1]
	5-(2,5-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide	IC50	20000.0 [1]
	CID 90309142	IC50	10000.0 [1]
	1-[[4-[5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	8.3 [1]
	[(3R)-3-Amino-4-(3-octylanilino)-4-oxobutyl]phosphonic acid	Ki	30.0 [1]
	[(2R)-2-Amino-2-[5-[4-[(4-phenylphenyl)methoxy]-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]propyl] dihydrogen phosphate	IC50	0.23 [1]
	1-(4-(3,4-Dichlorobenzyloxy)-2-methylbenzyl)azetidine-3-carboxylic acid	IC50	166.0 [1]
	1-[(2-Chloro-4-phenylmethoxyphenyl)methyl]azetidine-3-carboxylic acid	IC50	4230.0 [1]
	1-[[2-Methyl-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	333.0 [1]
	1-[[2-Fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	680.0 [1]
	1-[[2-Chloro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	256.0 [1]
	1-[[4-[(2,4-Dichlorophenyl)methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	835.0 [1]
	1-(4-(3-(Trifluoromethyl)phenethyl)benzyl)azetidine-3-carboxylic acid	IC50	221.0 [1]
	CID 54580603	IC50	20000.0 [1]
	4-[3-(4-Fluorophenoxy)-5-[[4-(4-fluorophenyl)-4-hydroxypiperidine-1-carbonyl]amino]phenoxy]benzoic acid	IC50	10000.0 [1]
	1-({4-[5-(4-Butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	2.9 [1]
	(3-Amino-heptadecyl)-phosphonic acid	IC50	19.0 [1]
	2-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	22.0 [1]
	3-Fluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	41.0 [1]
	[3-(3-Chloro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.3 [1]
	[3-(3-Ethoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	2.5 [1]
	1-(4-Nonylbenzyl)azetidine-3-carboxylic acid	IC50	18.0 [1]
	[3-(3-Methyl-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.5 [1]
	[3-(3,5-Dichloro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.6 [1]
	[3-(4-Octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.5 [1]
	[3-(4-Nonanoyl-benzylamino)-propyl]-phosphonic acid	IC50	0.9 [1]
	[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	14.0 [1]
	[3-(4-Nonyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.3 [1]
	[3-(3-Methoxy-5-methyl-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	2.3 [1]
	[3-(3-Chloro-5-methoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	2.4 [1]
	[3-(3-Bromo-5-methoxy-4-nonyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.4 [1]
	[3-(3-Bromo-5-methoxy-4-undecyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.2 [1]
	1-[(4-Octylphenyl)methyl]azetidine-3-carboxylic acid	IC50	18.0 [1]
	2,2-Difluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	44.0 [1]
	[3-(3-Fluoro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.7 [1]
	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)pyrrolidine-3-carboxylic acid	IC50	4.3 [1]
	(3-Amino-hexadecyl)-phosphonic acid	IC50	25.0 [1]
	1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acid	IC50	20.0 [1]
	4-[(3-Phosphono-propylamino)-methyl]-benzoic acid heptyl ester	IC50	2.3 [1]
	(3-Amino-henicosyl)-phosphonic acid	IC50	1600.0 [1]
	1-(3-Chloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	3.2 [1]
	4-(4-Nonyl-benzylamino)-butyric acid	IC50	7.7 [1]
	1-({4-[5-(4-Tert-butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	3.8 [1]
	1-[(4-{5-[4-(Propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]azetidine-3-carboxylic acid	IC50	1.8 [1]
	1-({4-[5-(4-Phenylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	1.7 [1]
	Methyl-[3-(4-nonyl-benzylamino)-propyl]-phosphinic acid	IC50	2.0 [1]
	{3-[4-(1-Hydroxy-nonyl)-benzylamino]-propyl}-phosphonic acid	IC50	32.0 [1]
	[3-(3-Methoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.9 [1]
	3-[[4-(4-Hexylphenyl)phenyl]methylamino]propylphosphonic acid	IC50	0.9 [1]
	[3-(3-Bromo-4-heptyloxy-5-methoxy-benzylamino)-propyl]-phosphonic acid	IC50	13.0 [1]
	1-(3-Methyl-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	1.8 [1]
	[3-(3,5-Dibromo-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.3 [1]
	3-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	14.0 [1]
	3-Amino-5-(4-octyl-phenyl)-pentane-1-sulfonic acid	IC50	1700.0 [1]
	[3-(3-Hydroxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	14.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Sphingosine 1-phosphate receptor Edg-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Sphingosine 1-phosphate receptor Edg-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-1-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan