Sphingosine 1-phosphate receptor Edg-5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	[3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid	IC50	0.7 [1], 5.5 [2], 320.0 [3], 750.0 [4], 10000.0 [5]
	3-(Tetradecylamino)propylphosphonic acid	IC50	13.0 [1], 580.0 [2]
	4-[3-(4-Fluorophenoxy)-5-[[4-(4-fluorophenyl)-4-hydroxypiperidine-1-carbonyl]amino]phenoxy]benzoic acid	IC50	6.2 [1], 430.0 [2]
	N-[3-(4-Carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	3.7 [1], 39.0 [2]
	Sphingosine 1-phosphate	IC50	0.23 [1], 0.35 [2], 3.6 [3]
	CID 10223146	IC50	10.0 [1], 20.0 [2], 58.4 [3]
	[(1R,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	4.5 [1], 33.0 [2], 10000.0 [3]
	3-(3-Bromo-5-methoxy-4-(octyloxy)benzylamino)propylphosphonic acid	IC50	10.0 [1], 10000.0 [2]
	Phosphonic acid, [3-amino-5-(4-octylphenyl)pentyl]-	IC50	100.0 [1], 10000.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide	IC50	1200.0 [1]
	FTY720 phosphate	IC50	0.77 [1], 1100.0 [2]
\n\n	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	Merck SIP Agonist	IC50	10000.0 [1]
	CID 90309142	IC50	8.2 [1], 500.0 [2]
	[3-(4-Octyl-benzylamino)-propyl]-phosphonic acid	IC50	5.5 [1], 10000.0 [2]
	1-(4-Nonylbenzyl)pyrrolidin-3-ylphosphonic acid	IC50	1000.0 [1], 10000.0 [2]
	(3-Amino-heptadecyl)-phosphonic acid	IC50	830.0 [1], 1200.0 [2]
	2-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	99.0 [1], 10000.0 [2]
	3-Fluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	57.0 [1], 1000.0 [2]
	[3-(3-Chloro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.7 [1], 10000.0 [2]
	[3-(3-Ethoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	12.0 [1], 10000.0 [2]
	[3-(3-Methyl-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.8 [1], 10000.0 [2]
	[3-(3,5-Dichloro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.0 [1], 10000.0 [2]
	[3-(4-Octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	6.3 [1], 4600.0 [2]
	[3-(4-Nonanoyl-benzylamino)-propyl]-phosphonic acid	IC50	4.0 [1], 8600.0 [2]
	[3-(4-Nonyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.7 [1], 840.0 [2]
	[3-(3-Methoxy-5-methyl-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	19.0 [1], 10000.0 [2]
	[3-(3-Chloro-5-methoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	8.0 [1], 10000.0 [2]
	[3-(3-Bromo-5-methoxy-4-nonyloxy-benzylamino)-propyl]-phosphonic acid	IC50	3.9 [1], 10000.0 [2]
	[3-(3-Bromo-5-methoxy-4-undecyloxy-benzylamino)-propyl]-phosphonic acid	IC50	1.9 [1], 10000.0 [2]
	2,2-Difluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	200.0 [1], 10000.0 [2]
	[3-(3-Fluoro-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	2.0 [1], 4700.0 [2]
	(3-Amino-hexadecyl)-phosphonic acid	IC50	86.0 [1], 10000.0 [2]
	4-[(3-Phosphono-propylamino)-methyl]-benzoic acid heptyl ester	IC50	680.0 [1], 10000.0 [2]
	(3-Amino-henicosyl)-phosphonic acid	IC50	1500.0 [1], 10000.0 [2]
	4-(4-Nonyl-benzylamino)-butyric acid	IC50	200.0 [1], 10000.0 [2]
	Methyl-[3-(4-nonyl-benzylamino)-propyl]-phosphinic acid	IC50	60.0 [1], 10000.0 [2]
	{3-[4-(1-Hydroxy-nonyl)-benzylamino]-propyl}-phosphonic acid	IC50	110.0 [1], 5400.0 [2]
	[3-(3-Methoxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	24.0 [1], 10000.0 [2]
	3-[[4-(4-Hexylphenyl)phenyl]methylamino]propylphosphonic acid	IC50	2.6 [1], 3400.0 [2]
	[3-(3-Bromo-4-heptyloxy-5-methoxy-benzylamino)-propyl]-phosphonic acid	IC50	6.1 [1], 10000.0 [2]
	[3-(3,5-Dibromo-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	3.0 [1], 10000.0 [2]
	3-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	66.0 [1], 10000.0 [2]
	[3-(3-Hydroxy-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	41.0 [1], 10000.0 [2]
	[3-(3,5-Dimethyl-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	0.8 [1], 10000.0 [2]
	[3-(3-Bromo-4-octyloxy-benzylamino)-propyl]-phosphonic acid	IC50	2.9 [1], 10000.0 [2]
	[3-(3-Bromo-4-decyloxy-5-methoxy-benzylamino)-propyl]-phosphonic acid	IC50	1.5 [1], 10000.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-methylphenyl]-4-hydroxypiperidine-1-carboxamide	IC50	500.0 [1]
	N-[3-Chloro-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	860.0 [1]
	N-[3-Ethoxy-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	1400.0 [1]
	N-[3,5-Bis(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	980.0 [1]
	N-[3-(3-Carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	13.0 [1], 150.0 [2]
	N-[3-[4-(Dimethylcarbamoyl)phenoxy]-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	8.8 [1], 43.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide	IC50	45.0 [1], 93.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-3-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide	IC50	210.0 [1], 940.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-2-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide	IC50	260.0 [1], 390.0 [2]
	(3-Hexadecylamino-propyl)-phosphonic acid	IC50	12.0 [1], 740.0 [2]
	[2-Amino-1-hydroxy-4-(4-octylphenyl)butan-2-yl] dihydrogen phosphate	IC50	0.8 [1], 1100.0 [2]
	(3-Tridecylamino-propyl)-phosphonic acid	IC50	38.0 [1], 150.0 [2]
	(3-Dodecylamino-propyl)-phosphonic acid	IC50	19.0 [1], 10000.0 [2]
	3-[[4-(5-Heptyl-1,2,4-oxadiazol-3-yl)phenyl]methylamino]propylphosphonic acid	IC50	1.8 [1], 1500.0 [2]
	{3-[4-(2-Heptyl-2H-tetrazol-5-yl)-benzylamino]-propyl}-phosphonic acid	IC50	1.4 [1], 2300.0 [2]
	{3-[4-(4-Heptyl-phenyl)-butylamino]-propyl}-phosphonic acid	IC50	590.0 [1], 2000.0 [2]
	3-[(4-Nonylphenyl)methylamino]propylphosphonous acid	IC50	140.0 [1], 10000.0 [2]
	[3-(10-Phenyl-decylamino)-propyl]-phosphonic acid	IC50	59.0 [1], 530.0 [2]
	(3-Pentadecylamino-propyl)-phosphonic acid	IC50	11.0 [1], 740.0 [2]
	{3-[3-(4-Heptyl-phenyl)-propylamino]-propyl}-phosphonic acid	IC50	42.0 [1], 2200.0 [2]
	{3-[2-(4-Octyl-phenyl)-ethylamino]-propyl}-phosphonic acid	IC50	45.0 [1], 10000.0 [2]
	(3-Amino-octadecyl)-phosphonic acid	IC50	450.0 [1], 10000.0 [2]
	(3-Amino-13-phenyl-tridecyl)-phosphonic acid	IC50	110.0 [1], 2100.0 [2]
	2-[4-[3-(4-Fluorophenoxy)-5-[[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]amino]phenoxy]phenyl]-2-methylpropanoic acid	IC50	2.3 [1]
	2-[4-[3-(4-Fluorophenoxy)-5-[[3-hydroxy-3-(2-methylpropyl)azetidine-1-carbonyl]amino]phenoxy]phenyl]-2-methylpropanoic acid	IC50	5.2 [1], 9.4 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-(4-sulfamoylphenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide	IC50	4.1 [1], 21.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-[4-(methylcarbamoyl)phenoxy]phenyl]-4-hydroxypiperidine-1-carboxamide	IC50	3.0 [1], 27.0 [2]
	N-[3-(2-Carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide	IC50	49.0 [1], 88.0 [2]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-(4-methylsulfonylphenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide	IC50	45.0 [1], 58.0 [2]
	(3-Amino-pentadecyl)-phosphonic acid	IC50	86.0 [1], 10000.0 [2]
	[3-(3-Bromo-4-hexyloxy-5-methoxy-benzylamino)-propyl]-phosphonic acid	IC50	6.2 [1], 6500.0 [2]
	Fingolimod	IC50	10000.0 [1]
	5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole	IC50	10000.0 [1]
	Fingolimod phosphate ester, S-	IC50	5.9 [1]
	Ceralifimod	Ki	5450.0 [1]
	N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide	IC50	3900.0 [1]
	CID 59393720	IC50	10000.0 [1]
	(2R)-2-Amino-2-[(phosphonooxy)methyl]-4-(4-octylphenyl)-1-butanol	IC50	22000.0 [1]
	1-[[4-[5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	10000.0 [1]
	3-(4-(5-(3-Cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoic acid	IC50	10000.0 [1]
	4-Amino-6-(4-octylphenyl)hexanoic Acid	IC50	1000.0 [1]
	3-Amino-5-(4-octylphenyl)pentanoic Acid	IC50	3300.0 [1]
	[2-Amino-4-(4-octylphenyl)butyl] dihydrogen phosphate	IC50	1.8 [1]
	[3-Amino-3-hydroxymethyl-5-(4-octyl-phenyl)-pentyl]-phosphonic acid	IC50	230.0 [1]
	1-{4-[5-(4-Tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-{4-[3-(4-Tert-butylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}azetidine-3-carboxylic acid	IC50	10000.0 [1]
	3-[3-Methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]propanoic acid	IC50	10000.0 [1]
	1-({4-[5-(4-Butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-(4-Nonylbenzyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	240.0 [1]
	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)pyrrolidine-3-carboxylic acid	IC50	10000.0 [1]
	1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acid	IC50	10000.0 [1]
	1-(3-Chloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sphingosine 1-phosphate receptor Edg-5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Sphingosine 1-phosphate receptor Edg-5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-5-inhibitors-ic50-ki.
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